2018
Respiratory syncytial virus activates epidermal growth factor receptor to suppress interferon regulatory factor 1-dependent interferon-lambda and antiviral defense in airway epithelium
Kalinowski A, Galen B, Ueki I, Sun Y, Mulenos A, Osafo-Addo A, Clark B, Joerns J, Liu W, Nadel J, Dela Cruz C, Koff J. Respiratory syncytial virus activates epidermal growth factor receptor to suppress interferon regulatory factor 1-dependent interferon-lambda and antiviral defense in airway epithelium. Mucosal Immunology 2018, 11: 958-967. PMID: 29411775, PMCID: PMC6431552, DOI: 10.1038/mi.2017.120.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusEpidermal growth factor receptorEGFR inhibitionGrowth factor receptorRSV infectionSyncytial virusViral infectionRegulatory factor 1Lower respiratory tract infectionsIFN-λ productionRespiratory tract infectionsChronic lung diseaseFactor receptorAntiviral immune responseFactor 1RSV F proteinType III IFNsAntiviral defenseEGFR activationInnate antiviral responseInterferon regulatory factor 1Cause pneumoniaRSV inducesSignificant IFNTyrosine kinase receptors
2013
Respiratory virus–induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium
Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL. Respiratory virus–induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium. Journal Of Experimental Medicine 2013, 210: 1929-1936. PMID: 23999497, PMCID: PMC3782052, DOI: 10.1084/jem.20121401.Peer-Reviewed Original ResearchConceptsEpithelial epidermal growth factor receptorViral infectionHost responseInnate antiviral host responsesEGFR activationIFN-λ productionIFN-λ signalingAntiviral immune responseImportance of IFNType III IFNsAntiviral defenseAntiviral host responseEpidermal growth factor receptorGrowth factor receptorSignificant IFNTyrosine kinase receptorsInterferon λNovel therapiesAirway epitheliumIFN regulatory factor-1Immune responseFuture therapiesViral pathogenesisAntiviral responseIFN