1996
Defining the roles of parathyroid hormone-related protein in normal physiology
Philbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, Stewart AF. Defining the roles of parathyroid hormone-related protein in normal physiology. Physiological Reviews 1996, 76: 127-173. PMID: 8592727, DOI: 10.1152/physrev.1996.76.1.127.BooksConceptsHormone-related proteinHumoral hypercalcemiaParathyroid hormone-related proteinSmooth muscle toneTransepithelial calcium transportMuscle tonePhysiological functionsAutocrine roleFetal lifeOwn receptorNormal physiological functionPTHrPPTHrP geneNormal tissuesCalcium transportNormal physiologyHypercalcemiaMalignancyRegulation of tissueCancerProhormone convertasesTissueVast majorityPosttranslational processingReview
1994
Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.
Wysolmerski JJ, Broadus AE, Zhou J, Fuchs E, Milstone LM, Philbrick WM. Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 1133-1137. PMID: 7508121, PMCID: PMC521468, DOI: 10.1073/pnas.91.3.1133.Peer-Reviewed Original ResearchConceptsFollicle developmentTransgenic miceHair follicle developmentHuman keratin 14 promoterParathyroid hormone-related proteinNormal hair follicle developmentOverexpression of PTHrPHormone-related proteinHormone-related peptideKeratin 14 promoterHumoral hypercalcemiaPTHrP geneNormal tissuesMicePTHrPSkinOverexpressionCellular differentiationEarly stagesHypercalcemiaMalignancySyndromePeptidesFollicles