2022
Cancer-Associated Hypercalcemia
Guise TA, Wysolmerski JJ. Cancer-Associated Hypercalcemia. New England Journal Of Medicine 2022, 386: 1443-1451. PMID: 35417639, DOI: 10.1056/nejmcp2113128.Peer-Reviewed Original Research
2013
Parathyroid Hormone‐Related Protein
Wysolmerski J. Parathyroid Hormone‐Related Protein. 2013, 215-223. DOI: 10.1002/9781118453926.ch27.Peer-Reviewed Original ResearchMouse geneticsNormal biologyType I PTH/PTHrP receptorNormal developmentPTH/PTHrP receptorNormal physiologyAction of PTHHormone-related proteinGrowth factorProteinHumoral hypercalcemiaDiverse sitesParathyroid hormonePhysiologyPTHrP receptorPTHrPPTHSystemic actionMammalsHypercalcemiaGeneticsBiologyFishPTHrP.ReproductionChapter 66 Disorders of Calcium Metabolism
Dumitru C, Wysolmerski J. Chapter 66 Disorders of Calcium Metabolism. 2013, 2273-2309. DOI: 10.1016/b978-0-12-381462-3.00066-5.Peer-Reviewed Original ResearchCalcium metabolismCalcium levelsParathyroid hormone-related proteinMulti-organ dysfunctionHormone-related proteinMetabolic bone disordersExtracellular calcium levelsParathyroid hormone receptorPrinciples of managementParathyroid hormoneBone metabolismBone disordersPrevalent causeCalcium homeostasisOrgan systemsHormone receptorsDisease statesHypercalcemiaHypocalcemiaDisordersNormal regulationHormoneMetabolismReceptorsCritical role
2012
Parathyroid Hormone-Related Protein: An Update
Wysolmerski JJ. Parathyroid Hormone-Related Protein: An Update. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: 2947-2956. PMID: 22745236, PMCID: PMC3431578, DOI: 10.1210/jc.2012-2142.BooksConceptsType 1 PTH/PTHrP receptorPTH/PTHrP receptorCauses of hypercalcemiaCommon paraneoplastic syndromeParaneoplastic syndromeHumoral hypercalcemiaParathyroid hormonePTHrP receptorBreast cancerNormal physiological functionPTHrPDisease statesTranslational researchHypercalcemiaOsteoporosisBedsidePhysiological functionsRelated genesHyperparathyroidismBasic biologyDiabetesMalignancyOsteoarthritisSyndromePTHPTHrP and breast cancer: more than hypercalcemia and bone metastases
Boras-Granic K, Wysolmerski JJ. PTHrP and breast cancer: more than hypercalcemia and bone metastases. Breast Cancer Research 2012, 14: 307. PMID: 22546075, PMCID: PMC3446368, DOI: 10.1186/bcr3129.BooksConceptsBone metastasesBreast cancerMMTV-PyMT miceNormal breast developmentPrimary breast tumorsHormone-related proteinBreast cancer susceptibility genesNew breast cancer susceptibility genesCancer patientsPrimary tumorCancer susceptibility genesClinical investigationBreast developmentBreast tumorsTumor growthPTHrPMetastasisHypercalcemiaTumorsCancerSusceptibility genesFurther researchPatientsMice
2005
Hypercalcemia in Breast Cancer: An Echo of Bone Mobilization During Lactation?
DeMauro S, Wysolmerski J. Hypercalcemia in Breast Cancer: An Echo of Bone Mobilization During Lactation? Journal Of Mammary Gland Biology And Neoplasia 2005, 10: 157-167. PMID: 16025222, DOI: 10.1007/s10911-005-5398-9.BooksConceptsBreast cancer patientsBone resorptionCancer patientsBreast cancerParathyroid hormone-related proteinPathophysiology of hypercalcemiaMultiple skeletal metastasesPathological bone resorptionHormone-related proteinActivation of osteoclastsSecretion of cytokinesClass of drugsSkeletal calcium storesNormal breast cellsFrequent complicationSkeletal metastasesSignificant morbidityCalcium metabolismCurrent therapiesHypercalcemiaNew therapiesCalcium levelsOsteoclast differentiationCalcium storesPatients
1998
THE PHYSIOLOGY OF PARATHYROID HORMONE-RELATED PROTEIN: An Emerging Role as a Developmental Factor
Wysolmerski JJ, Stewart AF. THE PHYSIOLOGY OF PARATHYROID HORMONE-RELATED PROTEIN: An Emerging Role as a Developmental Factor. Annual Review Of Physiology 1998, 60: 431-460. PMID: 9558472, DOI: 10.1146/annurev.physiol.60.1.431.BooksConceptsRole of PTHrPHormone-related proteinVascular smooth muscle toneParathyroid hormone-related proteinSmooth muscle tonePancreatic islet massMechanism of actionIntracrine regulatorHumoral hypercalcemiaMuscle tonePathogenic roleIslet massPTHrPDevelopmental factorsMammary glandEmerging RoleCalcium transferCell deathNormal developmentalAdult physiologySecretory formCell growthHypercalcemiaMalignancySyndrome
1996
Parathyroid Hormone-Related Protein: From Hypercalcemia of Malignancy to Developmental Regulatory Molecule
Dunbar M, Wysolmerski J, Broadus A. Parathyroid Hormone-Related Protein: From Hypercalcemia of Malignancy to Developmental Regulatory Molecule. The American Journal Of The Medical Sciences 1996, 312: 287-294. PMID: 8969618, DOI: 10.1097/00000441-199612000-00007.Peer-Reviewed Original ResearchConceptsDevelopmental regulatory moleculeCommon metabolic complicationHypercalcemia of malignancyHormone-related proteinParathyroid hormone receptorTypes of cancerMetabolic complicationsHumoral hypercalcemiaParathyroid hormoneRegulatory moleculesParacrine fashionBiochemical manifestationsMalignant cellsHypercalcemiaFetal tissuesPTHrPHormone receptorsNormal biological functionsMalignancyMolecular evolutionHHMBiological functionsMolecular mechanismsComplicationsKidneyParathyroid Hormone-Related Protein: From Hypercalcemia of Malignancy to Developmental Regulatory Molecule
Dunbar M, Wysolmerski J, Broadus A. Parathyroid Hormone-Related Protein: From Hypercalcemia of Malignancy to Developmental Regulatory Molecule. The American Journal Of The Medical Sciences 1996, 312: 287-294. DOI: 10.1016/s0002-9629(15)41844-0.Peer-Reviewed Original ResearchConceptsDevelopmental regulatory moleculeCommon metabolic complicationHypercalcemia of malignancyHormone-related proteinParathyroid hormone receptorTypes of cancerMetabolic complicationsHumoral hypercalcemiaParathyroid hormoneRegulatory moleculesParacrine fashionBiochemical manifestationsMalignant cellsHypercalcemiaFetal tissuesPTHrPHormone receptorsNormal biological functionsMalignancyMolecular evolutionHHMBiological functionsMolecular mechanismsComplicationsKidneyTransactivation of the PTHrP gene in squamous carcinomas predicts the occurrence of hypercalcemia in athymic mice.
Wysolmerski JJ, Vasavada R, Foley J, Weir EC, Burtis WJ, Kukreja SC, Guise TA, Broadus AE, Philbrick WM. Transactivation of the PTHrP gene in squamous carcinomas predicts the occurrence of hypercalcemia in athymic mice. Cancer Research 1996, 56: 1043-9. PMID: 8640759.Peer-Reviewed Original ResearchConceptsPTHrP gene expressionPTHrP mRNA expressionSquamous tumorsTumor linesAthymic miceMRNA expressionParathyroid hormone-related proteinOccurrence of hypercalcemiaPTHrP mRNA levelsHormone-related proteinSquamous histologyGene expressionPTHrP secretionHumoral hypercalcemiaSquamous carcinomaPTHrP gene promoterPTHrP mRNAHypercalcemiaSecretion ratePTHrP geneTumor cellsTumorsMRNA levelsHigh levelsHHMDefining the roles of parathyroid hormone-related protein in normal physiology
Philbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, Stewart AF. Defining the roles of parathyroid hormone-related protein in normal physiology. Physiological Reviews 1996, 76: 127-173. PMID: 8592727, DOI: 10.1152/physrev.1996.76.1.127.BooksConceptsHormone-related proteinHumoral hypercalcemiaParathyroid hormone-related proteinSmooth muscle toneTransepithelial calcium transportMuscle tonePhysiological functionsAutocrine roleFetal lifeOwn receptorNormal physiological functionPTHrPPTHrP geneNormal tissuesCalcium transportNormal physiologyHypercalcemiaMalignancyRegulation of tissueCancerProhormone convertasesTissueVast majorityPosttranslational processingReview
1994
Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.
Wysolmerski JJ, Broadus AE, Zhou J, Fuchs E, Milstone LM, Philbrick WM. Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 1133-1137. PMID: 7508121, PMCID: PMC521468, DOI: 10.1073/pnas.91.3.1133.Peer-Reviewed Original ResearchConceptsFollicle developmentTransgenic miceHair follicle developmentHuman keratin 14 promoterParathyroid hormone-related proteinNormal hair follicle developmentOverexpression of PTHrPHormone-related proteinHormone-related peptideKeratin 14 promoterHumoral hypercalcemiaPTHrP geneNormal tissuesMicePTHrPSkinOverexpressionCellular differentiationEarly stagesHypercalcemiaMalignancySyndromePeptidesFolliclesHYPERCALCEMIA OF MALIGNANCY: The Central Role of Parathyroid Hormone-Related Protein
Wysolmerski J, Broadus A. HYPERCALCEMIA OF MALIGNANCY: The Central Role of Parathyroid Hormone-Related Protein. Annual Review Of Medicine 1994, 45: 189-200. PMID: 8198376, DOI: 10.1146/annurev.med.45.1.189.Peer-Reviewed Original ResearchConceptsLocal osteolytic hypercalcemiaMalignancy-associated hypercalcemiaHormone-related protein gene expressionParathyroid hormone-related proteinCommon metabolic complicationCommon clinical problemLocal paracrine factorsHormone-related proteinParathyroid hormone-related protein gene expressionHHM syndromeMetabolic complicationsHumoral hypercalcemiaParathyroid hormoneBone resorptionHypercalcemiaParacrine roleClinical problemParacrine factorsSyndromeRecent dataProtein gene expressionHormoneMolecular mechanismsGene expressionComplications
1987
Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy.
Burtis WJ, Wu T, Bunch C, Wysolmerski JJ, Insogna KL, Weir EC, Broadus AE, Stewart AF. Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. Journal Of Biological Chemistry 1987, 262: 7151-7156. PMID: 3584110, DOI: 10.1016/s0021-9258(18)48217-8.Peer-Reviewed Original Research