Methionine sulfoxide reductase B2 protects against cardiac complications in diabetes mellitus
Lee S, Cho S, Lee J, Kim J, Kim S, Jeong M, Hong J, Kim G, Lee S, Kim E, Kim J, Kim J, Hwa J, Kim W. Methionine sulfoxide reductase B2 protects against cardiac complications in diabetes mellitus. Diabetology & Metabolic Syndrome 2024, 16: 149. PMID: 38970135, PMCID: PMC11225187, DOI: 10.1186/s13098-024-01390-0.Peer-Reviewed Original ResearchDiabetes mellitusCardiac fibrosisDiabetic cardiomyopathyReactive oxygen speciesAbnormal electrophysiological functionIncreased cardiac fibrosisMethionine sulfoxide reductase B2Chronic metabolic disorderIncreased ROSDiabetic mouse modelCardiac complicationsCardiac damageHeart failureKnockout miceDM miceElectrophysiological functionMouse modelHeart damageMetabolic disordersHistological analysisStructural pathologyCardiac tissueMiceExcessive reactive oxygen speciesHeart samples