2010
Variation in the gene encoding the serotonin transporter is associated with a measure of sociopathy in alcoholics
Herman AI, Conner TS, Anton RF, Gelernter J, Kranzler HR, Covault J. Variation in the gene encoding the serotonin transporter is associated with a measure of sociopathy in alcoholics. Addiction Biology 2010, 16: 124-132. PMID: 20192950, PMCID: PMC2888710, DOI: 10.1111/j.1369-1600.2009.00197.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholics AnonymousAlcoholismAllelesAntisocial Personality DisorderCognitive Behavioral TherapyFemaleGene FrequencyGenetic VariationGenotypeHumansMaleMiddle AgedMotivationPersonality InventoryPolymorphism, GeneticPsychotherapySerotonin Plasma Membrane Transport ProteinsSex FactorsConceptsAlcohol dependenceAlcohol use disorderAlcohol Treatment TrialSerotonin transporter proteinSocialization scoresTreatment trialsPsychiatric disordersUse disordersInsertion-deletion polymorphismTri-allelicInventory scoresSerotonin transporterSingle nucleotide polymorphismsWomenLower socialization scoresProject MATCHRegression analysisScoresShort allele
2004
Central Serotonin Transporter Availability Measured With 123I-CIT SPECT in Relation to Serotonin Transporter Genotype
van Dyck CH, Malison RT, Staley JK, Jacobsen LK, Seibyl JP, Laruelle M, Baldwin RM, Innis RB, Gelernter J. Central Serotonin Transporter Availability Measured With 123I-CIT SPECT in Relation to Serotonin Transporter Genotype. American Journal Of Psychiatry 2004, 161: 525-531. PMID: 14992979, DOI: 10.1176/appi.ajp.161.3.525.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAllelesBrainBrain MappingCarrier ProteinsCocaineFemaleGene FrequencyGenotypeHumansIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsMiddle AgedNerve Tissue ProteinsPolymorphism, GeneticPromoter Regions, GeneticReference ValuesSerotonin Plasma Membrane Transport ProteinsTandem Repeat SequencesTomography, Emission-Computed, Single-PhotonConceptsSERT availabilitySerotonin transporter proteinEuropean-American subjectsSERT levelsCentral serotonin transporter availabilitySLC6A4 promoter polymorphismSerotonin transporter availabilitySingle photon emissionEffect of ageLong alleleSerotonin transmissionBrain uptakeLong homozygotesAmerican subjectsTransporter availabilityPromoter polymorphismSerotonin transporter genotypeClinical phenotypeTomography scanningNeuropsychiatric diseasesNonneural cellsFunctional polymorphismsSLC6A4 genotypeNonsignificant tendencyTransporter genotype
2003
Alleles of a Functional Serotonin Transporter Promoter Polymorphism Are Associated With Major Depression in Alcoholics
Nellissery M, Feinn RS, Covault J, Gelernter J, Anton RF, Pettinati H, Moak D, Mueller T, Kranzler HR. Alleles of a Functional Serotonin Transporter Promoter Polymorphism Are Associated With Major Depression in Alcoholics. Alcohol Clinical And Experimental Research 2003, 27: 1402-1408. PMID: 14506400, DOI: 10.1097/01.alc.0000085588.11073.bb.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismAllelesBlack PeopleCarrier ProteinsChromosome MappingComorbidityDepressive Disorder, MajorFemaleGene FrequencyGenotypeHumansMaleMembrane GlycoproteinsMembrane Transport ProteinsMiddle AgedNerve Tissue ProteinsPhenotypePolymerase Chain ReactionPolymorphism, GeneticPromoter Regions, GeneticSerotonin Plasma Membrane Transport ProteinsWhite PeopleConceptsMajor depressionComorbid alcohol dependenceAlcohol dependenceFunctional serotonin transporter promoter polymorphismAfrican American patientsSubstance use disordersSerotonin transporter promoter polymorphismShort alleleTransporter promoter polymorphismSerotonin transporter proteinAntidepressant treatmentPatient groupAmerican patientsSerotonergic neurotransmissionDepressed alcoholicsMood disordersPromoter polymorphismUnipolar depressionUse disordersControl groupTreatment studiesFunctional polymorphismsGenetic predictorsSerotonin transporterWhole blood
1998
Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder
McDougle CJ, Epperson CN, Price LH, Gelernter J. Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder. Molecular Psychiatry 1998, 3: 270-273. PMID: 9672904, DOI: 10.1038/sj.mp.4000391.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderCompulsive disorderTreatment of OCDSerotonin transporter proteinHeterozygous parentsMedication targetsDrug nonrespondersMeasures of anxietyInhibitor drugsProtein expressionSerotonin transporter protein geneSLC6A4 allelesLinkage disequilibriumBehavioral phenotypes