2006
Genomewide Linkage Scan for Nicotine Dependence: Identification of a Chromosome 5 Risk Locus
Gelernter J, Panhuysen C, Weiss R, Brady K, Poling J, Krauthammer M, Farrer L, Kranzler HR. Genomewide Linkage Scan for Nicotine Dependence: Identification of a Chromosome 5 Risk Locus. Biological Psychiatry 2006, 61: 119-126. PMID: 17081504, DOI: 10.1016/j.biopsych.2006.08.023.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingChromosomes, Human, Pair 5FemaleGene FrequencyGenetic LinkageGenetic Predisposition to DiseaseHumansLod ScoreMaleMixed Function OxygenasesMultienzyme ComplexesNuclear FamilyPedigreePhenotypePolymorphism, Single NucleotideReproducibility of ResultsRetrospective StudiesTobacco Use DisorderConceptsRisk lociLinkage scanGenomewide linkage scanSignificant single-nucleotide polymorphism associationsGenetic linkage analysisSingle nucleotide polymorphism associationsHighest LOD scoreLinkage peakChromosome 5Linkage signalChromosome 7Small nuclear familiesLinkage analysisPeptidylglycine alphaLociLOD scoreDistinct populationsMultiple individualsGenesEA subjectsPhysiological hypothesisPolymorphism associationAA partEuropean Americans
2004
Genome-Wide Linkage Scan for Loci Predisposing to Social Phobia: Evidence for a Chromosome 16 Risk Locus
Gelernter J, Page GP, Stein MB, Woods SW. Genome-Wide Linkage Scan for Loci Predisposing to Social Phobia: Evidence for a Chromosome 16 Risk Locus. American Journal Of Psychiatry 2004, 161: 59-66. PMID: 14702251, DOI: 10.1176/appi.ajp.161.1.59.Peer-Reviewed Original ResearchConceptsGenome-wide linkage scanLinkage scanChromosome 16LOD scoreGenetic linkage analysisNorepinephrine transporter proteinLinkage genome scanGenomic locationEntire genomeChromosome 16 markersGenome scanMultipoint LOD scoreRisk lociTransporter proteinsGenetic markersLinkage analysisSusceptibility lociChromosome 9Physiological candidatesLocus predisposingLociZlr scoreAmerican pedigreesX softwareD16S415