2015
Percutaneous Coronary Intervention Utilization and Appropriateness across the United States
Thomas MP, Parzynski CS, Curtis JP, Seth M, Nallamothu BK, Chan PS, Spertus JA, Patel MR, Bradley SM, Gurm HS. Percutaneous Coronary Intervention Utilization and Appropriateness across the United States. PLOS ONE 2015, 10: e0138251. PMID: 26379053, PMCID: PMC4575022, DOI: 10.1371/journal.pone.0138251.Peer-Reviewed Original ResearchConceptsAppropriate use criteriaHospital referral regionsPCI utilizationQuintile 5PCI ratesQuintiles 1PCI appropriatenessPercutaneous coronary intervention useMedicare Limited Data SetRisk-adjusted mortalityNCDR CathPCI RegistryElective PCICathPCI RegistryInappropriate indicationsPatient characteristicsStudy cohortAppropriate indicationsPCI proceduresHeart AssociationCardiovascular AngiographyStudy populationAmerican CollegeReferral regionsSubstantial geographic variationIntervention utilizationFrequency and Effects of Excess Dosing of Anticoagulants in Patients ≤55 Years With Acute Myocardial Infarction Who Underwent Percutaneous Coronary Intervention (from the VIRGO Study)
Gupta A, Chui P, Zhou S, Spertus JA, Geda M, Lorenze N, Lee I, Onofrio G, Lichtman JH, Alexander KP, Krumholz HM, Curtis JP. Frequency and Effects of Excess Dosing of Anticoagulants in Patients ≤55 Years With Acute Myocardial Infarction Who Underwent Percutaneous Coronary Intervention (from the VIRGO Study). The American Journal Of Cardiology 2015, 116: 1-7. PMID: 25937348, PMCID: PMC4466069, DOI: 10.1016/j.amjcard.2015.03.032.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAngioplasty, Balloon, CoronaryAnticoagulantsAntithrombinsBody Mass IndexCohort StudiesFemaleHemorrhageHeparinHirudinsHumansMaleMiddle AgedMyocardial InfarctionPeptide FragmentsPercutaneous Coronary InterventionPlatelet Glycoprotein GPIIb-IIIa ComplexPrevalenceRecombinant ProteinsRisk AssessmentRisk FactorsSex DistributionTreatment OutcomeUnited StatesConceptsPercutaneous coronary interventionGlycoprotein IIb/IIIa inhibitorsIIb/IIIa inhibitorsExcess dosingAcute myocardial infarctionCoronary interventionMultivariable analysisMyocardial infarctionUnderwent Percutaneous Coronary InterventionLower body weightOlder patientsYounger patientsUnfractionated heparinMedical recordsUnivariate analysisAnticoagulant agentsAnticoagulant drugsBody weightPatientsDosingYounger ageLogistic regressionYoung womenAnticoagulantsGender-based differences
2013
Door-to-Balloon Time and Mortality among Patients Undergoing Primary PCI
Menees DS, Peterson ED, Wang Y, Curtis JP, Messenger JC, Rumsfeld JS, Gurm HS. Door-to-Balloon Time and Mortality among Patients Undergoing Primary PCI. New England Journal Of Medicine 2013, 369: 901-909. PMID: 24004117, DOI: 10.1056/nejmoa1208200.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIST-segment elevation myocardial infarctionElevation myocardial infarctionBalloon timeHospital mortalityMyocardial infarctionNational quality improvement initiativePercentage of patientsPercutaneous coronary interventionQuality improvement initiativesMedicare data setSignificant overall changeCathPCI RegistryCoronary interventionMedian doorSubgroup analysis
2012
The Prevalence and Outcomes of Transradial Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Analysis From the National Cardiovascular Data Registry (2007 to 2011)
Baklanov DV, Kaltenbach LA, Marso SP, Subherwal SS, Feldman DN, Garratt KN, Curtis JP, Messenger JC, Rao SV. The Prevalence and Outcomes of Transradial Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Analysis From the National Cardiovascular Data Registry (2007 to 2011). Journal Of The American College Of Cardiology 2012, 61: 420-426. PMID: 23265340, PMCID: PMC3883049, DOI: 10.1016/j.jacc.2012.10.032.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryBlood Loss, SurgicalComparative Effectiveness ResearchDrug-Eluting StentsElectrocardiographyFemaleFemoral ArteryHospital MortalityHumansIntraoperative CareMaleMiddle AgedMyocardial InfarctionOutcome and Process Assessment, Health CarePrevalenceRadial ArteryRegistriesRisk FactorsTime-to-TreatmentTreatment OutcomeUnited StatesConceptsST-segment elevation myocardial infarctionPercutaneous coronary interventionTransradial percutaneous coronary interventionHospital mortalityBalloon timeTransradial PCICoronary interventionProcedural successFemoral approachRadial accessFemoral-access percutaneous coronary interventionNational Cardiovascular Data RegistryLonger median doorPost-PCI bleedingElevation myocardial infarctionLarge national databaseLow bleeding ratesCathPCI RegistryVascular complicationsLonger doorMedian doorFemoral accessMyocardial infarctionBleeding rateAccess siteBleeding-Avoidance Strategies and Outcomes in Patients ≥80 Years of Age With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (from the NCDR CathPCI Registry)
Dodson JA, Wang Y, Chaudhry SI, Curtis JP. Bleeding-Avoidance Strategies and Outcomes in Patients ≥80 Years of Age With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (from the NCDR CathPCI Registry). The American Journal Of Cardiology 2012, 110: 1-6. PMID: 22475362, PMCID: PMC3666171, DOI: 10.1016/j.amjcard.2012.02.039.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAged, 80 and overAngioplasty, Balloon, CoronaryConnecticutElectrocardiographyFemaleHumansIncidenceMaleMyocardial InfarctionPostoperative HemorrhageRegistriesRetrospective StudiesRisk FactorsConceptsPrimary percutaneous coronary interventionPrimary PCIBleeding-avoidance strategiesST-segment elevation myocardial infarctionElevation myocardial infarctionPercutaneous coronary interventionMyocardial infarctionCoronary interventionUndergoing primary percutaneous coronary interventionST-elevation myocardial infarctionDirect thrombin inhibitorVascular closure deviceYears of ageBleeding complicationsCathPCI RegistryMultivariable analysisRadial accessClosure deviceHigh riskBleedingPatientsThrombin inhibitorsInfarctionLow bleedingStudy periodCharacteristics and Long-Term Outcomes of Percutaneous Revascularization of Unprotected Left Main Coronary Artery Stenosis in the United States A Report From the National Cardiovascular Data Registry, 2004 to 2008
Brennan JM, Dai D, Patel MR, Rao SV, Armstrong EJ, Messenger JC, Curtis JP, Shunk KA, Anstrom KJ, Eisenstein EL, Weintraub WS, Peterson ED, Douglas PS, Hillegass WB. Characteristics and Long-Term Outcomes of Percutaneous Revascularization of Unprotected Left Main Coronary Artery Stenosis in the United States A Report From the National Cardiovascular Data Registry, 2004 to 2008. Journal Of The American College Of Cardiology 2012, 59: 648-654. PMID: 22322080, DOI: 10.1016/j.jacc.2011.10.883.Peer-Reviewed Original ResearchConceptsULMCA percutaneous coronary interventionPercutaneous coronary interventionMain coronary artery stenosisU.S. clinical practiceMajor adverse eventsCoronary artery stenosisAdverse eventsULMCA stenosisCoronary interventionHazard ratioArtery stenosisUnprotected left main coronary artery stenosisClinical practiceLeft main coronary artery stenosisComposite major adverse eventsUnited States A ReportPercutaneous coronary intervention registryHospital mortality rateCoronary Intervention RegistryLong-term outcomesHigh procedural riskBare metal stentsDrug-eluting stentsHospital mortalityPCI use
2011
Use and Effectiveness of Intra-Aortic Balloon Pumps Among Patients Undergoing High Risk Percutaneous Coronary Intervention
Curtis JP, Rathore SS, Wang Y, Chen J, Nallamothu BK, Krumholz HM. Use and Effectiveness of Intra-Aortic Balloon Pumps Among Patients Undergoing High Risk Percutaneous Coronary Intervention. Circulation Cardiovascular Quality And Outcomes 2011, 5: 21-30. PMID: 22147887, PMCID: PMC3801197, DOI: 10.1161/circoutcomes.110.960385.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCoronary DiseaseFemaleHemodynamicsHospital MortalityHumansIntra-Aortic Balloon PumpingMaleMiddle AgedRegistriesRiskTreatment OutcomeConceptsHigh-risk percutaneous coronary interventionIntra-aortic balloon pumpPercutaneous coronary interventionHospital quartilesHospital mortalityIABP useCoronary interventionBalloon pumpHospital characteristicsST-segment elevation myocardial infarctionDepressed left ventricular functionHigh-risk PCI patientsSegment elevation myocardial infarctionElevation myocardial infarctionLeft ventricular functionHierarchical logistic regression modelsLogistic regression modelsIABP usageCardiogenic shockPCI patientsCathPCI RegistryHemodynamic supportVentricular functionHospital variationMultivariable analysisFactors Associated With 30-Day Readmission Rates After Percutaneous Coronary Intervention
Khawaja FJ, Shah ND, Lennon RJ, Slusser JP, Alkatib AA, Rihal CS, Gersh BJ, Montori VM, Holmes DR, Bell MR, Curtis JP, Krumholz HM, Ting HH. Factors Associated With 30-Day Readmission Rates After Percutaneous Coronary Intervention. JAMA Internal Medicine 2011, 172: 112-117. PMID: 22123752, PMCID: PMC3688066, DOI: 10.1001/archinternmed.2011.569.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngina, UnstableAngioplasty, Balloon, CoronaryCoronary Artery BypassEducational StatusFemaleFollow-Up StudiesHeart FailureHumansIschemic Attack, TransientKidney DiseasesLength of StayMaleMedicareMultivariate AnalysisMyocardial InfarctionNeoplasm MetastasisPatient ReadmissionPeptic UlcerProportional Hazards ModelsPulmonary Disease, Chronic ObstructiveRegistriesSex FactorsStrokeUnited StatesConceptsPercutaneous coronary interventionThirty-day readmissionReadmission ratesCoronary interventionHigh riskChronic obstructive pulmonary diseaseThirty-day readmission ratesCox proportional hazards modelMultivariate logistic regression modelTransient ischemic attackCongestive heart failureObstructive pulmonary diseasePeptic ulcer diseaseSevere renal diseaseAcute myocardial infarctionLength of stayMain outcome measuresProportional hazards modelSaint Mary's HospitalLogistic regression modelsIschemic attackTime-dependent covariatesUnstable anginaCerebrovascular accidentHeart failureImprovements in Door-to-Balloon Time in the United States, 2005 to 2010
Krumholz HM, Herrin J, Miller LE, Drye EE, Ling SM, Han LF, Rapp MT, Bradley EH, Nallamothu BK, Nsa W, Bratzler DW, Curtis JP. Improvements in Door-to-Balloon Time in the United States, 2005 to 2010. Circulation 2011, 124: 1038-1045. PMID: 21859971, PMCID: PMC3598634, DOI: 10.1161/circulationaha.111.044107.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryFemaleHealth Care SurveysHospitalsHumansMaleMiddle AgedMyocardial InfarctionRegistriesTime FactorsUnited StatesYoung AdultConceptsPrimary percutaneous coronary interventionPercutaneous coronary interventionBalloon timeCoronary interventionMedian timeST-segment elevation myocardial infarctionHigher median timeCharacteristics of patientsPercentage of patientsTimeliness of treatmentYears of ageRegistry studyMyocardial infarctionInpatient measuresPatientsHospital groupMedicaid ServicesCalendar yearInterventionMinutesMedianGroupYearsPercentageInfarction
2010
Trends in Race-Based Differences in Door-to-Balloon Times
Curtis JP, Herrin J, Bratzler DW, Bradley EH, Krumholz HM. Trends in Race-Based Differences in Door-to-Balloon Times. JAMA Internal Medicine 2010, 170: 992-993. PMID: 20548015, DOI: 10.1001/archinternmed.2010.165.Peer-Reviewed Original ResearchDifferences in Patient Survival After Acute Myocardial Infarction by Hospital Capability of Performing Percutaneous Coronary Intervention: Implications for Regionalization
Chen J, Krumholz HM, Wang Y, Curtis JP, Rathore SS, Ross JS, Normand SL, Schreiner GC, Mulvey G, Nallamothu BK. Differences in Patient Survival After Acute Myocardial Infarction by Hospital Capability of Performing Percutaneous Coronary Intervention: Implications for Regionalization. JAMA Internal Medicine 2010, 170: 433-439. PMID: 20212179, PMCID: PMC2900156, DOI: 10.1001/archinternmed.2009.538.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, Balloon, CoronaryFemaleHospitalsHumansMaleMyocardial InfarctionOutcome Assessment, Health CareRegistriesSurvival AnalysisSurvival RateTreatment OutcomeUnited StatesConceptsRisk-standardized mortality ratesNon-PCI hospitalsPercutaneous coronary interventionAcute myocardial infarctionHospital referral regionsPCI hospitalsHealth care regionCoronary interventionAMI patientsMyocardial infarctionCare regionLower risk-standardized mortality ratesSame hospital referral regionService beneficiaries 65 yearsBeneficiaries 65 yearsMagnitude of benefitPatient survivalAMI careReferral regionsOutcome differencesMedicare feeMortality rateHospitalHospital capabilitiesInfarction
2009
National Efforts to Improve Door-to-Balloon Time Results From the Door-to-Balloon Alliance
Bradley EH, Nallamothu BK, Herrin J, Ting HH, Stern AF, Nembhard IM, Yuan CT, Green JC, Kline-Rogers E, Wang Y, Curtis JP, Webster TR, Masoudi FA, Fonarow GC, Brush JE, Krumholz HM. National Efforts to Improve Door-to-Balloon Time Results From the Door-to-Balloon Alliance. Journal Of The American College Of Cardiology 2009, 54: 2423-2429. PMID: 20082933, DOI: 10.1016/j.jacc.2009.11.003.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryEfficiency, OrganizationalHospitalizationHospitalsHumansLongitudinal StudiesMyocardial InfarctionQuality Assurance, Health CareRegistriesTime FactorsUnited StatesConceptsST-segment elevation myocardial infarctionD2B AllianceBalloon (D2B) AllianceHospital presentationD2B timeNational Cardiovascular Data Registry CathPCI RegistryPrimary percutaneous coronary interventionElevation myocardial infarctionPercutaneous coronary interventionLikelihood of patientsCathPCI RegistryCoronary interventionBalloon timeMyocardial infarctionAmerican CollegePatientsHospitalLongitudinal studyNational Quality CampaignOne-halfPresentationMinNational effortsInfarctionRegistryAssociation of Door-to-Balloon Time and Mortality in Patients ≥65 Years With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Rathore SS, Curtis JP, Nallamothu BK, Wang Y, Foody JM, Kosiborod M, Masoudi FA, Havranek EP, Krumholz HM. Association of Door-to-Balloon Time and Mortality in Patients ≥65 Years With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. The American Journal Of Cardiology 2009, 104: 1198-1203. PMID: 19840562, PMCID: PMC2790921, DOI: 10.1016/j.amjcard.2009.06.034.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIST-elevation myocardial infarctionPercutaneous coronary interventionBalloon timeMyocardial infarctionCoronary interventionAssociation of doorMinutes of admissionSecond-degree fractional polynomialsLogistic regression analysisFractional polynomial modelsMultivariable adjustmentLonger doorMedian doorCurrent guidelinesPatientsMortalityInfarctionRegression analysisFractional polynomialsAssociationInterventionMinutesTreatmentAll-Cause Readmission and Repeat Revascularization After Percutaneous Coronary Intervention in a Cohort of Medicare Patients
Curtis JP, Schreiner G, Wang Y, Chen J, Spertus JA, Rumsfeld JS, Brindis RG, Krumholz HM. All-Cause Readmission and Repeat Revascularization After Percutaneous Coronary Intervention in a Cohort of Medicare Patients. Journal Of The American College Of Cardiology 2009, 54: 903-907. PMID: 19712799, DOI: 10.1016/j.jacc.2009.04.076.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCoronary DiseaseFee-for-Service PlansFemaleHospitalsHumansMaleMedicareMyocardial InfarctionMyocardial RevascularizationPatient ReadmissionRetreatmentUnited StatesConceptsPercutaneous coronary interventionReadmission ratesRevascularization proceduresCause readmissionCoronary interventionPCI proceduresMortality rateIndex percutaneous coronary interventionAcute myocardial infarction patientsCause readmission rateIndex PCI procedureMedian readmission rateDays of dischargeRepeat revascularization proceduresMyocardial infarction patientsNon-AMI patientsPCI patientsRepeat revascularizationRevascularization ratesPrimary outcomeInfarction patientsSuch readmissionsMedicare patientsRetrospective analysisReadmission
2008
Delay in Presentation and Reperfusion Therapy in ST-Elevation Myocardial Infarction
Ting HH, Bradley EH, Wang Y, Nallamothu BK, Gersh BJ, Roger VL, Lichtman JH, Curtis JP, Krumholz HM. Delay in Presentation and Reperfusion Therapy in ST-Elevation Myocardial Infarction. The American Journal Of Medicine 2008, 121: 316-323. PMID: 18374691, PMCID: PMC2373574, DOI: 10.1016/j.amjmed.2007.11.017.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, Balloon, CoronaryEarly DiagnosisElectrocardiographyEmergency Medical ServicesEmergency Service, HospitalFemaleFollow-Up StudiesHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionMyocardial RevascularizationOdds RatioProbabilityRegistriesRetrospective StudiesRisk FactorsSurvival AnalysisThrombolytic TherapyTime FactorsTreatment OutcomeConceptsST-elevation myocardial infarctionReperfusion therapyHospital presentationBalloon timeSymptom onsetLonger doorMyocardial infarctionDrug timePrimary reperfusion therapyCohort studyLate presentersNeedle timeNational registryPatientsReduced likelihoodTherapyInfarctionLong delayPresentationOnsetHoursAssociationMinutesRegistry
2007
Comparing Hospital Performance in Door-to-Balloon Time Between the Hospital Quality Alliance and the National Cardiovascular Data Registry
Nallamothu BK, Wang Y, Bradley EH, Ho KK, Curtis JP, Rumsfeld JS, Masoudi FA, Krumholz HM. Comparing Hospital Performance in Door-to-Balloon Time Between the Hospital Quality Alliance and the National Cardiovascular Data Registry. Journal Of The American College Of Cardiology 2007, 50: 1517-1519. PMID: 17919575, DOI: 10.1016/j.jacc.2007.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryData CollectionHospitalsHumansMyocardial InfarctionProcess Assessment, Health CareQuality Indicators, Health CareRegistriesTime and Motion StudiesUnited StatesSummary of Evidence Regarding Hospital Strategies to Reduce Door-to-Balloon Times for Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Bradley EH, Nallamothu BK, Curtis JP, Webster TR, Magid DJ, Granger CB, Moscucci M, Krumholz HM. Summary of Evidence Regarding Hospital Strategies to Reduce Door-to-Balloon Times for Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. Critical Pathways In Cardiology A Journal Of Evidence-Based Medicine 2007, 6: 91-97. PMID: 17804968, DOI: 10.1097/hpc.0b013e31812da7bc.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryElectrocardiographyHospitalizationHospitalsHumansMyocardial InfarctionPractice Guidelines as TopicTime FactorsConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionPercutaneous coronary interventionBalloon timeCoronary interventionCross-sectional designMyocardial infarctionCatheterization laboratoryPrompt percutaneous coronary interventionPrimary percutaneous coronary interventionHospital-based strategiesEmergency medicine physiciansHospital strategiesSummary of evidenceRandomized trialsPrehospital electrocardiogramCatheterization teamObservational studyMedicine physiciansClinical importanceComputerized searchPatientsEffective interventionsHospitalHospital efforts
2006
Strategies for Reducing the Door-to-Balloon Time in Acute Myocardial Infarction
Bradley EH, Herrin J, Wang Y, Barton BA, Webster TR, Mattera JA, Roumanis SA, Curtis JP, Nallamothu BK, Magid DJ, McNamara RL, Parkosewich J, Loeb JM, Krumholz HM. Strategies for Reducing the Door-to-Balloon Time in Acute Myocardial Infarction. New England Journal Of Medicine 2006, 355: 2308-2320. PMID: 17101617, DOI: 10.1056/nejmsa063117.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryCross-Sectional StudiesEmergency Medical ServicesEmergency Service, HospitalHospitalsHumansLinear ModelsMultivariate AnalysisMyocardial InfarctionTime FactorsConceptsST-segment elevationBalloon timeCatheterization laboratoryMyocardial infarctionFaster doorEmergency departmentPrimary percutaneous coronary interventionHospital strategiesIntracoronary balloon inflationPercutaneous coronary interventionAcute myocardial infarctionMinority of hospitalsEmergency medicine physiciansReperfusion treatmentCoronary interventionBalloon inflationMedicine physiciansMultivariate analysisHospitalInfarctionPatientsMedicaid ServicesSignificant reductionReal-time data feedbackData feedbackEffect of Door-to-Balloon Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction
McNamara RL, Wang Y, Herrin J, Curtis JP, Bradley EH, Magid DJ, Peterson ED, Blaney M, Frederick PD, Krumholz HM, Investigators N. Effect of Door-to-Balloon Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction. Journal Of The American College Of Cardiology 2006, 47: 2180-2186. PMID: 16750682, DOI: 10.1016/j.jacc.2005.12.072.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-segment elevation myocardial infarctionBalloon timeElevation myocardial infarctionSymptom onsetMyocardial infarctionHospital mortalityPatient characteristicsDoor timeEffect of doorPrimary PCIBaseline risk statusPercutaneous coronary interventionHigh-risk factorsSTEMI patientsCohort studyCoronary interventionLonger doorEntire cohortSubgroup analysisNational registryBaseline riskMortality riskPatientsMortalityThe Pre-Hospital Electrocardiogram and Time to Reperfusion in Patients With Acute Myocardial Infarction, 2000–2002 Findings From the National Registry of Myocardial Infarction-4
Curtis JP, Portnay EL, Wang Y, McNamara RL, Herrin J, Bradley EH, Magid DJ, Blaney ME, Canto JG, Krumholz HM. The Pre-Hospital Electrocardiogram and Time to Reperfusion in Patients With Acute Myocardial Infarction, 2000–2002 Findings From the National Registry of Myocardial Infarction-4. Journal Of The American College Of Cardiology 2006, 47: 1544-1552. PMID: 16630989, DOI: 10.1016/j.jacc.2005.10.077.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryElectrocardiographyFemaleHospitalizationHumansMaleMiddle AgedMyocardial InfarctionMyocardial ReperfusionRegistriesThrombolytic TherapyTime FactorsConceptsST-segment elevation myocardial infarctionPre-hospital electrocardiogramPrimary percutaneous coronary interventionMyocardial infarction 4Mean doorReperfusion timeHospital characteristicsNational registryTreatment of STEMILimited contemporary informationElevation myocardial infarctionPercutaneous coronary interventionBundle branch blockAcute reperfusionECG usePCI cohortReperfusion therapyBalloon timeCoronary interventionFibrinolytic therapyTherapy cohortMyocardial infarctionBranch blockNational guidelinesDrug time