2014
Validated Contemporary Risk Model of Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Interventions: Insights From the National Cardiovascular Data Registry Cath‐PCI Registry
Tsai TT, Patel UD, Chang TI, Kennedy KF, Masoudi FA, Matheny ME, Kosiborod M, Amin AP, Weintraub WS, Curtis JP, Messenger JC, Rumsfeld JS, Spertus JA. Validated Contemporary Risk Model of Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Interventions: Insights From the National Cardiovascular Data Registry Cath‐PCI Registry. Journal Of The American Heart Association 2014, 3: e001380. PMID: 25516439, PMCID: PMC4338731, DOI: 10.1161/jaha.114.001380.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAge FactorsAgedBiomarkersComorbidityCreatinineDecision Support TechniquesFemaleGlomerular Filtration RateHumansKidneyMaleMiddle AgedPercutaneous Coronary InterventionPredictive Value of TestsRegistriesRenal DialysisReproducibility of ResultsRisk AssessmentRisk FactorsSeverity of Illness IndexTreatment OutcomeUnited StatesConceptsAcute kidney injuryPercutaneous coronary interventionCardiogenic shockKidney injuryCoronary interventionHeart failureValidation cohortPreventative strategiesRisk of PCIPrior percutaneous coronary interventionAKI prediction modelBaseline renal impairmentConsecutive PCI patientsContemporary risk modelsPrior cerebrovascular diseasePrior heart failureChronic lung diseaseRisk-stratify patientsLocal quality improvement effortsQuality improvement effortsGood discriminationBaseline CKDSTEMI presentationPCI patientsPCI registry
2012
Cellularity and structure of fresh human coronary thrombectomy specimens; presence of cells with markers of progenitor cells
Jovin IS, Lei L, Huang Y, Hao Z, Curtis JP, Brennan JJ, Remetz MS, Setaro JF, Pfau SE, Howes CJ, Clancy JF, Cabin HS, Cleman MW, Giordano FJ. Cellularity and structure of fresh human coronary thrombectomy specimens; presence of cells with markers of progenitor cells. Journal Of Cellular And Molecular Medicine 2012, 16: 3022-3027. PMID: 22947374, PMCID: PMC4393730, DOI: 10.1111/j.1582-4934.2012.01629.x.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeCoronary thrombectomyCoronary syndromeProgenitor cellsCholesterol crystalsAcute myocardial infarctionEndothelial progenitor cellsFormation of thrombiHaematopoietic progenitor cellsVon Willebrand factorInflammatory cellsEndothelial cell mediumMyocardial infarctionPlaque ruptureThrombectomyImmunohistochemical analysisVascular wallPresence of cellsBlood cellsWillebrand factorThrombus
2011
Elevated B-Type Natriuretic Peptide Is Associated With Increased In-Hospital Mortality or Cardiac Arrest in Patients Undergoing Implantable Cardioverter-Defibrillator Implantation
Wei S, Loyo-Berríos NI, Haigney MC, Cheng H, Pinnow EE, Mitchell KR, Beachy JH, Woodward AM, Wang Y, Curtis JP, Marinac-Dabic D. Elevated B-Type Natriuretic Peptide Is Associated With Increased In-Hospital Mortality or Cardiac Arrest in Patients Undergoing Implantable Cardioverter-Defibrillator Implantation. Circulation Cardiovascular Quality And Outcomes 2011, 4: 346-354. PMID: 21487093, DOI: 10.1161/circoutcomes.110.943621.Peer-Reviewed Original ResearchConceptsElevated BNP levelsHospital mortalityCardiac arrestBNP levelsICD implantationElevated B-type natriuretic peptide (BNP) levelsNational Cardiovascular Data Registry ICD RegistryB-type natriuretic peptide levelsElevated B-type natriuretic peptideIncreased In-Hospital MortalityB-type natriuretic peptideImplantable cardioverter defibrillator implantationBiventricular ICD implantationHigh BNP groupNatriuretic peptide levelsIn-Hospital MortalityCardioverter-defibrillator implantationHierarchical logistic regressionBNP measurementHospital deathPeriprocedural complicationsRenal dysfunctionComplication rateBNP groupHeart failure
2007
Preventing tomorrow's sudden cardiac death today Part I: Current data on risk stratification for sudden cardiac death
Al-Khatib SM, Sanders GD, Bigger JT, Buxton AE, Califf RM, Carlson M, Curtis A, Curtis J, Fain E, Gersh BJ, Gold MR, Haghighi-Mood A, Hammill SC, Healey J, Hlatky M, Hohnloser S, Kim RJ, Lee K, Mark D, Mianulli M, Mitchell B, Prystowsky EN, Smith J, Steinhaus D, Zareba W, conference F. Preventing tomorrow's sudden cardiac death today Part I: Current data on risk stratification for sudden cardiac death. American Heart Journal 2007, 153: 941-950. PMID: 17540194, DOI: 10.1016/j.ahj.2007.03.003.Peer-Reviewed Original ResearchConceptsSudden cardiac deathRisk stratificationCardiac deathHeart diseasePrevention of SCDLeft ventricular ejection fractionDuke Clinical Research InstituteOvert heart diseaseVentricular ejection fractionStructural heart diseaseHeart Rhythm SocietyClinical Research InstituteImplantable cardioverter defibrillatorCurrent dataEjection fractionSuch patientsSCD eventsCardioverter defibrillatorUS FoodDrug AdministrationPredictive valuePatientsDuke CenterClinical cardiologyEffective prevention
2005
Anemia and Outcomes in Patients With Heart Failure: A Study From the National Heart Care Project
Kosiborod M, Curtis JP, Wang Y, Smith GL, Masoudi FA, Foody JM, Havranek EP, Krumholz HM. Anemia and Outcomes in Patients With Heart Failure: A Study From the National Heart Care Project. JAMA Internal Medicine 2005, 165: 2237-2244. PMID: 16246989, DOI: 10.1001/archinte.165.19.2237.Peer-Reviewed Original ResearchConceptsHeart failureLower hematocrit levelsIndependent predictorsHematocrit levelsComorbid illnessesHigh riskCare ProjectMultivariable logistic regression analysisPatients 65 yearsPrincipal discharge diagnosisAcute care hospitalsLogistic regression analysisLow hematocrit valuesCause mortalityHF patientsMultiple comorbiditiesMultivariable adjustmentOlder patientsCare hospitalClinical factorsHospital readmissionComorbid conditionsDischarge diagnosisSevere anemiaAdverse outcomesThe significance of elevated troponin T in patients with nondialysis‐dependent renal insufficiency: A validation with coronary angiography
Heitner JF, Curtis JP, Haq SA, Corey GR, Newby LK, Jollis JG. The significance of elevated troponin T in patients with nondialysis‐dependent renal insufficiency: A validation with coronary angiography. Clinical Cardiology 2005, 28: 333-336. PMID: 16075826, PMCID: PMC6653870, DOI: 10.1002/clc.4960280706.Peer-Reviewed Original ResearchConceptsPoor renal functionCoronary artery diseaseLength of stayNondialysis-dependent renal insufficiencyElevated troponin TNormal renal functionRenal functionElevated cTnTCoronary angiographyCAD stenosisContrast nephropathyPositive cTnTRenal insufficiencyPrevalence of CADTroponin TSignificant coronary artery diseaseSignificant coronary artery stenosisImpaired renal functionAcute coronary syndromeFuture cardiac eventsInitiation of hemodialysisGlomerular filtration rateCoronary artery stenosisElevated cTnT.Hospital mortality