2024
Real-World Experience and Outcomes With Percutaneous Coronary Intervention for Protected Versus Unprotected Left Main Coronary Artery Disease: Insights from the Veteran Affairs Clinical Assessment Reporting and Tracking Program
Gonzalez P, Hebbe A, Hussain Y, Khera R, Banerjee S, Plomondon M, Waldo S, Pfau S, Curtis J, Shah S. Real-World Experience and Outcomes With Percutaneous Coronary Intervention for Protected Versus Unprotected Left Main Coronary Artery Disease: Insights from the Veteran Affairs Clinical Assessment Reporting and Tracking Program. The American Journal Of Cardiology 2024, 222: 39-50. PMID: 38677666, DOI: 10.1016/j.amjcard.2024.04.039.Peer-Reviewed Original ResearchULM percutaneous coronary interventionPercutaneous coronary interventionPropensity-matched cohortMyocardial infarctionCoronary interventionAll-cause mortalityTracking programUS clinical practiceOne-year MACEOne-year outcomesIncidence of rehospitalizationAdverse cardiovascular eventsUnprotected left main coronary artery diseaseAcute coronary syndromeCoronary artery diseaseRates of MIMechanical circulatory supportLeft main percutaneous coronary interventionPCI patientsUrgent revascularizationPractice patternsCart programLeft main bifurcationPrimary outcomeMatched cohort
2023
Complex Percutaneous Coronary Intervention Outcomes in Older Adults
Hanna J, Wang S, Kochar A, Park D, Damluji A, Henry G, Ahmad Y, Curtis J, Nanna M. Complex Percutaneous Coronary Intervention Outcomes in Older Adults. Journal Of The American Heart Association 2023, 12: e029057. PMID: 37776222, PMCID: PMC10727245, DOI: 10.1161/jaha.122.029057.Peer-Reviewed Original ResearchConceptsNoncomplex percutaneous coronary interventionsComplex percutaneous coronary interventionStable ischemic heart diseasePercutaneous coronary interventionIschemic heart diseaseTarget lesion revascularizationEvent-free survivalHeart diseaseOlder adultsCause deathLesion revascularizationClinical characteristicsElective percutaneous coronary interventionPercutaneous coronary intervention outcomesWorse event-free survivalMedical therapy useCox regression modelLarge health systemNoncardiac comorbiditiesRevascularization riskCoronary interventionTherapy useClinical outcomesDisease featuresLower riskContemporary Methods for Predicting Acute Kidney Injury After Coronary Intervention
Uzendu A, Kennedy K, Chertow G, Amin A, Giri J, Rymer J, Bangalore S, Lavin K, Anderson C, Wang T, Curtis J, Spertus J. Contemporary Methods for Predicting Acute Kidney Injury After Coronary Intervention. JACC Cardiovascular Interventions 2023, 16: 2294-2305. PMID: 37758384, PMCID: PMC10795198, DOI: 10.1016/j.jcin.2023.07.041.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPercutaneous coronary interventionValidation cohortKidney injuryCoronary interventionClinical careIncidence of AKIBedside risk scoreBaseline renal functionNCDR CathPCI RegistryLogistic regression modelsAKI riskNew dialysisAKI predictionCathPCI RegistryRenal functionCommon complicationDerivation cohortMedian ageAKI modelClinical instabilityPCI proceduresC-statisticPatient riskContrast dosesAssociation Between Claims‐Defined Frailty and Outcomes Following 30 Versus 12 Months of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: Findings From the EXTEND‐DAPT Study
Faridi K, Strom J, Kundi H, Butala N, Curtis J, Gao Q, Song Y, Zheng L, Tamez H, Shen C, Secemsky E, Yeh R. Association Between Claims‐Defined Frailty and Outcomes Following 30 Versus 12 Months of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: Findings From the EXTEND‐DAPT Study. Journal Of The American Heart Association 2023, 12: e029588. PMID: 37449567, PMCID: PMC10382113, DOI: 10.1161/jaha.123.029588.Peer-Reviewed Original ResearchConceptsExtended duration dual antiplatelet therapyDuration dual antiplatelet therapyNet adverse clinical eventsDual antiplatelet therapyAdverse clinical eventsPercutaneous coronary interventionCoronary interventionClinical eventsNonfrail patientsAntiplatelet therapyFrail patientsClaims dataMonths of DAPTClaims-based indexYears of ageMajor bleedingCause mortalityMultivariable adjustmentOlder patientsDAPT studyResults PatientsBackground FrailtyMyocardial infarctionClinical trialsMedicare claimsLong-Term Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention Among Medicare Beneficiaries
Almarzooq Z, Tamez H, Wang Y, Curtis J, Kirtane A, Secemsky E, Valsdottir L, Yeh R. Long-Term Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention Among Medicare Beneficiaries. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100584. PMID: 39129810, PMCID: PMC11307545, DOI: 10.1016/j.jscai.2023.100584.Peer-Reviewed Original ResearchNon-CTO percutaneous coronary interventionCTO percutaneous coronary interventionPercutaneous coronary interventionLong-term major adverse cardiovascular eventsChronic total occlusion (CTO) percutaneous coronary interventionMajor adverse cardiovascular eventsAdverse cardiovascular eventsHospital eventsHigh riskCardiovascular eventsCoronary interventionMyocardial infarctionLower riskNational Cardiovascular Data Registry CathPCI RegistryST-elevation myocardial infarctionHospital event ratesElevation myocardial infarctionLong-term outcomesRepeat revascularizationStable anginaCathPCI RegistryResults PatientsTerm outcomesPCI proceduresMedicare beneficiaries
2022
In-hospital outcomes and readmission in older adults treated with percutaneous coronary intervention for stable ischemic heart disease
Park DY, Hanna JM, Kadian S, Kadian M, Jones WS, Damluji AA, Kochar A, Curtis JP, Nanna MG. In-hospital outcomes and readmission in older adults treated with percutaneous coronary intervention for stable ischemic heart disease. Journal Of Geriatric Cardiology 2022, 19: 631-642. PMID: 36284680, PMCID: PMC9548058, DOI: 10.11909/j.issn.1671-5411.2022.09.006.Peer-Reviewed Original ResearchStable ischemic heart diseasePercutaneous coronary interventionInpatient percutaneous coronary interventionIschemic heart diseaseHospital mortalityOlder adultsIndex hospitalizationCoronary interventionHospital chargesHeart diseaseNational Readmission DatabaseTotal hospital chargesHigh-risk cohortOlder adult patientsPeriprocedural morbidityCardiovascular causesGastrointestinal hemorrhageHospital lengthHospital outcomesAdult patientsSecondary outcomesLonger LOSPrimary outcomeIntracranial hemorrhageProcedural riskE-4 | Long-term Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention Among Medicare Beneficiaries
Almarzooq Z, Tamez H, Wang Y, Curtis J, Kirtane A, Secemsky E, Valsdottir L, Yeh R. E-4 | Long-term Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention Among Medicare Beneficiaries. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100264. DOI: 10.1016/j.jscai.2022.100264.Peer-Reviewed Original ResearchChronic total occlusion (CTO) percutaneous coronary interventionPercutaneous coronary interventionLong-term outcomesCoronary interventionMedicare beneficiaries
2021
Estimation of DAPT Study Treatment Effects in Contemporary Clinical Practice: Findings From the EXTEND-DAPT Study
Butala NM, Faridi KF, Tamez H, Strom JB, Song Y, Shen C, Secemsky EA, Mauri L, Kereiakes DJ, Curtis JP, Gibson CM, Yeh RW. Estimation of DAPT Study Treatment Effects in Contemporary Clinical Practice: Findings From the EXTEND-DAPT Study. Circulation 2021, 145: 97-106. PMID: 34743530, PMCID: PMC8748407, DOI: 10.1161/circulationaha.121.056878.Peer-Reviewed Original ResearchConceptsContemporary clinical practiceStent-treated patientsPercutaneous coronary interventionDAPT studyProlonged DAPTClinical practiceCoronary interventionMyocardial infarctionNational Cardiovascular Data Registry CathPCI RegistryTreatment effectsTrial resultsAttenuation of benefitLonger-duration DAPTMonths of DAPTProlonged DAPT durationDrug-eluting stentsCoronary stent proceduresModern clinical practiceGreater bleedingMore comorbiditiesRegistry patientsAntiplatelet therapyCerebrovascular eventsDAPT durationMore contemporary cohortsComparison of Patients Undergoing Percutaneous Coronary Intervention in Contemporary U.S. Practice With ISCHEMIA Trial Population
Chatterjee S, Fanaroff AC, Parzynski C, Curtis J, Kolansky DM, Maddox TM, Mukherjee D, Yeh RW, Giri J. Comparison of Patients Undergoing Percutaneous Coronary Intervention in Contemporary U.S. Practice With ISCHEMIA Trial Population. JACC Cardiovascular Interventions 2021, 14: 2344-2349. PMID: 34736733, DOI: 10.1016/j.jcin.2021.08.047.Peer-Reviewed Original ResearchConceptsStable ischemic heart diseasePercutaneous coronary interventionISCHEMIA trialSIHD patientsCoronary interventionNational Cardiovascular Data Registry CathPCI RegistryStudy periodHospital mortality rateHigh-risk featuresProportion of patientsTrial inclusion criteriaComparison of patientsIschemic heart diseaseCross-sectional analysisIschemic burdenMedian hospitalAngina symptomsCathPCI RegistryTrial populationComparator groupEnrollment criteriaMyocardial infarctionHeart diseaseU.S. patientsInclusion criteriaThe bleeding risk treatment paradox at the physician and hospital level: Implications for reducing bleeding in patients undergoing percutaneous coronary intervention
Amin AP, Frogge N, Kulkarni H, Ridolfi G, Ewald G, Miller R, Hall B, Rogers S, Gluckman T, Curtis J, Masoudi FA, Rao SV. The bleeding risk treatment paradox at the physician and hospital level: Implications for reducing bleeding in patients undergoing percutaneous coronary intervention. American Heart Journal 2021, 243: 221-231. PMID: 34543645, DOI: 10.1016/j.ahj.2021.08.021.Peer-Reviewed Original ResearchConceptsRisk-treatment paradoxPercutaneous coronary interventionVascular closure deviceCoronary interventionClosure deviceBAS useNational Cardiovascular Data Registry CathPCINational Cardiovascular Data Registry CathPCI RegistryPost-PCI bleedingHigh-risk tertileHigher bleeding rateInter-physician variationLevel of physiciansPCI patientsCathPCI RegistryIndependent predictorsTransradial interventionRisk tertilesCostly complicationBleeding rateHigh prevalenceHigh riskMortality riskBleedingLower riskComparative Outcomes of Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Among Medicare Beneficiaries With Multivessel Coronary Artery Disease
Secemsky EA, Butala N, Raja A, Khera R, Wang Y, Curtis JP, Maddox TM, Virani SS, Armstrong EJ, Shunk KA, Brindis RG, Bhatt D, Yeh RW. Comparative Outcomes of Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Among Medicare Beneficiaries With Multivessel Coronary Artery Disease. Circulation Cardiovascular Interventions 2021, 14: e010323. PMID: 34372676, PMCID: PMC8485756, DOI: 10.1161/circinterventions.120.010323.Peer-Reviewed Original ResearchPredicting In-Hospital Mortality in Patients Undergoing Percutaneous Coronary Intervention
Castro-Dominguez YS, Wang Y, Minges KE, McNamara RL, Spertus JA, Dehmer GJ, Messenger JC, Lavin K, Anderson C, Blankinship K, Mercado N, Clary JM, Osborne AD, Curtis JP, Cavender MA. Predicting In-Hospital Mortality in Patients Undergoing Percutaneous Coronary Intervention. Journal Of The American College Of Cardiology 2021, 78: 216-229. PMID: 33957239, DOI: 10.1016/j.jacc.2021.04.067.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionHospital mortalityQuality improvement effortsCoronary interventionDevelopment cohortValidation cohortRisk-standardized mortality ratesHospital risk-standardized mortality ratesBedside risk scoreHigh-risk patientsIn-Hospital MortalityHospital mortality riskRisk of mortalityLevel of consciousnessProcedural urgencyCathPCI RegistryClinical presentationRisk cohortRisk stratificationCardiovascular instabilityCardiac arrestMortality riskRisk scoreClinical acuityClinical relevanceIN-HOSPITAL MORTALITY RISK PREDICTION FOR PERCUTANEOUS CORONARY INTERVENTIONS: AN UPDATED MODEL FROM THE NCDR CATHPCI REGISTRY
Dominguez Y, Minges K, Wang Y, McNamara R, Spertus J, Dehmer G, Messenger J, Mercado N, Lavin K, Pierre D, Anderson C, Blankinship K, Clary J, Osborne A, Curtis J, Cavender M. IN-HOSPITAL MORTALITY RISK PREDICTION FOR PERCUTANEOUS CORONARY INTERVENTIONS: AN UPDATED MODEL FROM THE NCDR CATHPCI REGISTRY. Journal Of The American College Of Cardiology 2021, 77: 1217. DOI: 10.1016/s0735-1097(21)02576-6.Peer-Reviewed Original ResearchPercutaneous coronary interventionNCDR CathPCI RegistryMortality risk predictionCathPCI RegistryCoronary interventionRisk predictionRegistryTemporal Changes and Institutional Variation in Use of Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction With Multivessel Coronary Artery Disease in the United States
Secemsky EA, Butala N, Raja A, Khera R, Wang Y, Curtis JP, Maddox TM, Virani SS, Armstrong EJ, Shunk KA, Brindis RG, Bhatt D, Yeh RW. Temporal Changes and Institutional Variation in Use of Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction With Multivessel Coronary Artery Disease in the United States. JAMA Cardiology 2021, 6: 574-580. PMID: 33146666, PMCID: PMC7643043, DOI: 10.1001/jamacardio.2020.5354.Peer-Reviewed Original ResearchConceptsMV-percutaneous coronary interventionST-elevation myocardial infarctionMultivessel percutaneous coronary interventionPercutaneous coronary interventionMajor epicardial vesselsPCI useMV diseaseCoronary interventionIndex procedureMyocardial infarctionSTEMI admissionsEpicardial vesselsNational Cardiovascular Data Registry CathPCI RegistryIndex percutaneous coronary interventionMore major epicardial vesselsMultivessel coronary artery diseaseCoronary stentsSmall randomized studiesDays of dischargeCoronary artery diseaseMinority of patientsIndex admissionNonculprit lesionsCathPCI RegistryComplete revascularizationPrognosis of Claims‐ Versus Trial‐Based Ischemic and Bleeding Events Beyond 1 Year After Coronary Stenting
Butala NM, Faridi KF, Secemsky EA, Song Y, Curtis J, Gibson CM, Kazi D, Shen C, Yeh RW. Prognosis of Claims‐ Versus Trial‐Based Ischemic and Bleeding Events Beyond 1 Year After Coronary Stenting. Journal Of The American Heart Association 2021, 10: e018744. PMID: 33682431, PMCID: PMC8174225, DOI: 10.1161/jaha.120.018744.Peer-Reviewed Original ResearchConceptsUnadjusted mortality ratesIschemic eventsDAPT studyMortality rateEnd pointCox proportional hazards modelPercutaneous coronary interventionProportional hazards modelCardiovascular clinical trialsTrial adjudicationBleeding eventsCathPCI RegistryCoronary interventionCoronary stentingSimilar prognosisPrognostic significanceClinical eventsClinical trialsMedicare claimsAdministrative claimsMortality riskHazards modelPatientsPrognosisDeathUse of Mechanical Circulatory Support Devices Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock
Dhruva SS, Ross JS, Mortazavi BJ, Hurley NC, Krumholz HM, Curtis JP, Berkowitz AP, Masoudi FA, Messenger JC, Parzynski CS, Ngufor CG, Girotra S, Amin AP, Shah ND, Desai NR. Use of Mechanical Circulatory Support Devices Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock. JAMA Network Open 2021, 4: e2037748. PMID: 33616664, PMCID: PMC7900859, DOI: 10.1001/jamanetworkopen.2020.37748.Peer-Reviewed Original ResearchMeSH KeywordsAgedAssisted CirculationCross-Sectional StudiesExtracorporeal Membrane OxygenationFemaleHeart ArrestHeart-Assist DevicesHospitals, High-VolumeHospitals, Low-VolumeHospitals, TeachingHumansIntra-Aortic Balloon PumpingMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionRisk FactorsShock, CardiogenicConceptsMicroaxial left ventricular assist deviceIntra-aortic balloon pumpLeft ventricular assist devicePercutaneous coronary interventionAcute myocardial infarctionMechanical circulatory support devicesCardiogenic shockHospital-level variationSignificant hospital-level variationCirculatory support devicesMCS devicesUse of IABPDevice useMedian proportionAcute Myocardial Infarction ComplicatedCardiology-National Cardiovascular Data RegistryChest Pain-MI RegistryLimited clinical trial evidenceNational Cardiovascular Data RegistryMyocardial Infarction ComplicatedFirst medical contactSupport devicesClinical trial evidenceExtracorporeal membrane oxygenationCoronary artery stenosisComparability of Event Adjudication Versus Administrative Billing Claims for Outcome Ascertainment in the DAPT Study
Faridi KF, Tamez H, Butala NM, Song Y, Shen C, Secemsky EA, Mauri L, Curtis JP, Strom JB, Yeh RW. Comparability of Event Adjudication Versus Administrative Billing Claims for Outcome Ascertainment in the DAPT Study. Circulation Cardiovascular Quality And Outcomes 2021, 14: e006589. PMID: 33435731, PMCID: PMC7855905, DOI: 10.1161/circoutcomes.120.006589.Peer-Reviewed Original ResearchConceptsNegative predictive valuePositive predictive valueMyocardial infarctionPredictive valueDAPT studyClinical trialsAdjudicated eventsClaims dataNational Cardiovascular Data Registry CathPCI RegistryClinical events committeeTrial of patientsPercutaneous coronary interventionTrial end pointsKappa statisticsAdjudicated deathCathPCI RegistryCerebrovascular eventsCoronary interventionCumulative incidenceEvents committeeOutcome ascertainmentBilling claimsInpatient hospitalizationBleeding rateCardiovascular disease
2020
Revascularization Practices and Outcomes in Patients With Multivessel Coronary Artery Disease Who Presented With Acute Myocardial Infarction and Cardiogenic Shock in the US, 2009-2018
Khera R, Secemsky EA, Wang Y, Desai NR, Krumholz HM, Maddox TM, Shunk KA, Virani SS, Bhatt DL, Curtis J, Yeh RW. Revascularization Practices and Outcomes in Patients With Multivessel Coronary Artery Disease Who Presented With Acute Myocardial Infarction and Cardiogenic Shock in the US, 2009-2018. JAMA Internal Medicine 2020, 180: 1317-1327. PMID: 32833024, PMCID: PMC9377424, DOI: 10.1001/jamainternmed.2020.3276.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCohort StudiesCoronary VesselsFemaleFollow-Up StudiesHospital MortalityHumansMaleMiddle AgedMyocardial InfarctionPatient DischargePercutaneous Coronary InterventionRisk AssessmentRisk FactorsShock, CardiogenicST Elevation Myocardial InfarctionTime FactorsTreatment OutcomeUnited StatesConceptsST-segment elevation myocardial infarctionMultivessel percutaneous coronary interventionMultivessel coronary artery diseasePercutaneous coronary interventionAcute myocardial infarctionCoronary artery diseaseCulprit vessel percutaneous coronary interventionCardiogenic shockHospital mortalityArtery diseaseMyocardial infarctionCohort studyPrimary outcomeHospital variationPCI strategyMedicare beneficiariesUnderwent multivessel PCISignificant hospital variationElevation myocardial infarctionSubset of patientsHigh-risk populationRecent evidenceHospital complicationsPCI useRevascularization practiceFacility Variation in Troponin Ordering Within the Veterans Health Administration
Chui PW, Esserman D, Bastian LA, Curtis JP, Gandhi PU, Rosman L, Desai N, Hauser RG. Facility Variation in Troponin Ordering Within the Veterans Health Administration. Medical Care 2020, 58: 1098-1104. PMID: 33003051, PMCID: PMC7666100, DOI: 10.1097/mlr.0000000000001424.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAge FactorsAgedAged, 80 and overComorbidityCross-Sectional StudiesDiagnosis-Related GroupsEmergency Service, HospitalGuideline AdherenceHumansMiddle AgedPractice Guidelines as TopicPractice Patterns, Physicians'Sex FactorsSocioeconomic FactorsTroponinUnited StatesUnited States Department of Veterans AffairsConceptsDownstream resource utilizationVeterans Health AdministrationCase mixHealth AdministrationCurrent United States guidelinesDownstream health care utilizationVeterans Health Administration facilitiesFacility characteristicsAcute coronary syndromeEmergency department visitsPercutaneous coronary interventionHealth care utilizationAcute care facilitiesUnited States guidelinesHigh rateCross-sectional analysisCoronary syndromeCoronary interventionED visitsDepartment visitsCare utilizationHighest quartileCoronary angiogramInpatient admissionsLowest quartileCharacteristics of cardiac catheterization laboratory directors at the 2017 U.S. News & World Report top 100 U.S. cardiovascular hospitals
Murugiah K, Annapureddy AR, Khera R, Lansky A, Curtis JP. Characteristics of cardiac catheterization laboratory directors at the 2017 U.S. News & World Report top 100 U.S. cardiovascular hospitals. Catheterization And Cardiovascular Interventions 2020, 97: e624-e626. PMID: 32833350, DOI: 10.1002/ccd.29217.Peer-Reviewed Original ResearchConceptsCardiac catheterization laboratoryCardiovascular HospitalFellowship trainingPercutaneous coronary interventionCardiac catheterization laboratory directorsStructural interventionsCoronary interventionMedian agePeripheral interventionsMedical school graduationCardiovascular programCatheterization laboratoryMedicare dataMedicare Provider UtilizationHospitalClinical focusMedian yearsProvider Utilization