2023
Complex Percutaneous Coronary Intervention Outcomes in Older Adults
Hanna J, Wang S, Kochar A, Park D, Damluji A, Henry G, Ahmad Y, Curtis J, Nanna M. Complex Percutaneous Coronary Intervention Outcomes in Older Adults. Journal Of The American Heart Association 2023, 12: e029057. PMID: 37776222, PMCID: PMC10727245, DOI: 10.1161/jaha.122.029057.Peer-Reviewed Original ResearchConceptsNoncomplex percutaneous coronary interventionsComplex percutaneous coronary interventionStable ischemic heart diseasePercutaneous coronary interventionIschemic heart diseaseTarget lesion revascularizationEvent-free survivalHeart diseaseOlder adultsCause deathLesion revascularizationClinical characteristicsElective percutaneous coronary interventionPercutaneous coronary intervention outcomesWorse event-free survivalMedical therapy useCox regression modelLarge health systemNoncardiac comorbiditiesRevascularization riskCoronary interventionTherapy useClinical outcomesDisease featuresLower riskVariation in hospital use of cardiac resynchronization therapy-defibrillator among eligible patients and association with clinical outcomes
Chui P, Lan Z, Freeman J, Enriquez A, Khera R, Akar J, Masoudi F, Ong E, Curtis J. Variation in hospital use of cardiac resynchronization therapy-defibrillator among eligible patients and association with clinical outcomes. Heart Rhythm 2023, 20: 1000-1008. PMID: 36963741, DOI: 10.1016/j.hrthm.2023.03.022.Peer-Reviewed Original ResearchConceptsEligible patientsICD RegistryCardiac resynchronizationNational Cardiovascular Data Registry ICD RegistryCRT-D implantationCRT-D useHospital-level outcomesStrong guideline recommendationsHospital-level variationPatient-level outcomesIntraclass correlation coefficientQuality improvement effortsHospital mortalityGuideline indicationsReadmission ratesSelect patientsClinical outcomesGuideline recommendationsHospital variationHospital ratesUse of CRTHospital levelHospital usePatientsCase mix
2022
Abnormal left atrial body stiffness is predicted by appendage size: impact of appendage occlusion on left atrial mechanics assessed by pressure-volume analysis
Bregasi A, Freeman JV, Curtis JP, Akar JG, Ortiz-Leon XA, Maia JH, Higgins AY, Matthews RV, Sinusas AJ, McNamara RL, Sugeng L, Lin BA. Abnormal left atrial body stiffness is predicted by appendage size: impact of appendage occlusion on left atrial mechanics assessed by pressure-volume analysis. AJP Heart And Circulatory Physiology 2022, 323: h559-h568. PMID: 35960632, PMCID: PMC9576173, DOI: 10.1152/ajpheart.00083.2022.Peer-Reviewed Original ResearchConceptsLeft atrial appendage occlusionLA stiffnessAppendage occlusionLA appendageLA mechanicsTransesophageal echocardiographyPressure-volume analysisPercutaneous left atrial appendage occlusionAdverse atrial remodelingAtrial appendage occlusionLeft atrial appendageLA volume measurementsAtrial cardiomyopathyBaseline characteristicsLA complianceAtrial remodelingClinical outcomesAtrial appendageAtrial mechanicsCardiac performancePathophysiological roleBaseline parametersMagnitude of increaseAppendage sizeOcclusionHP-573-04 VARIATION IN HOSPITAL USE OF CRT-D AMONG ELIGIBLE PATIENTS AND ASSOCIATION WITH CLINICAL OUTCOMES
Chui P, Lan Z, Curtis J. HP-573-04 VARIATION IN HOSPITAL USE OF CRT-D AMONG ELIGIBLE PATIENTS AND ASSOCIATION WITH CLINICAL OUTCOMES. Heart Rhythm 2022, 19: s44-s45. DOI: 10.1016/j.hrthm.2022.03.668.Peer-Reviewed Original ResearchClinical Outcomes at 1 Year Following Transcatheter Left Atrial Appendage Occlusion in the United States
Price MJ, Slotwiner D, Du C, Freeman JV, Turi Z, Rammohan C, Kusumoto FM, Kavinsky C, Akar J, Varosy PD, Koutras C, Curtis JP, Masoudi FA. Clinical Outcomes at 1 Year Following Transcatheter Left Atrial Appendage Occlusion in the United States. JACC Cardiovascular Interventions 2022, 15: 741-750. PMID: 35393108, PMCID: PMC9116488, DOI: 10.1016/j.jcin.2022.02.009.Peer-Reviewed Original ResearchConceptsAtrial appendage occlusionIschemic strokeMajor bleedingClinical outcomesSystemic embolismAppendage occlusionMean HAS-BLED scoreHAS-BLED scoreKey secondary endpointKaplan-Meier methodCumulative event rateRate of mortalityMean CHAPrior strokeRelevant bleedingVASc scoreWATCHMAN procedurePrimary endpointSecondary endpointsThromboembolic eventsIntracranial bleedingBlood transfusionHemoglobin levelsHemorrhagic strokeKaplan-Meier
2020
Comparison of left ventricular lead upgrade vs continued medical care among patients eligible for cardiac resynchronization therapy at the time of defibrillator generator replacement: Predictors of left ventricular lead upgrade and associations with long-term outcomes
Hyman MC, Bao H, Curtis JP, Minges K, Schaller RD, Birgersdotter-Green U, Marchlinski FE, Hsu JC. Comparison of left ventricular lead upgrade vs continued medical care among patients eligible for cardiac resynchronization therapy at the time of defibrillator generator replacement: Predictors of left ventricular lead upgrade and associations with long-term outcomes. Heart Rhythm 2020, 17: 1878-1886. PMID: 32497762, DOI: 10.1016/j.hrthm.2020.05.032.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyCRT-eligible patientsCRT upgradeResynchronization therapyClinical outcomesNational Cardiovascular Data Registry ICD RegistryGenerator replacementPeriprocedural complication rateLeft ventricular leadSubpopulation of patientsLong-term outcomesICD generator replacementHierarchical logistic regression modelsLogistic regression modelsSecondary endpointsCause mortalityPrimary endpointComplication rateICD RegistryProcedural complicationsMedical managementICD populationNational registryVentricular leadClaims data
2019
The Evolving Landscape of Impella® Use in the United States Among Patients Undergoing Percutaneous Coronary Intervention with Mechanical Circulatory Support
Amin AP, Spertus JA, Curtis JP, Desai N, Masoudi FA, Bach RG, McNeely C, Al-Badarin F, House JA, Kulkarni H, Rao SV. The Evolving Landscape of Impella® Use in the United States Among Patients Undergoing Percutaneous Coronary Intervention with Mechanical Circulatory Support. Circulation 2019, 141: 273-284. PMID: 31735078, DOI: 10.1161/circulationaha.119.044007.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionMechanical circulatory supportAcute kidney injuryImpella useOdds ratioKidney injuryCoronary interventionClinical outcomesCirculatory supportAdverse outcomesPremier Healthcare DatabaseClustering of patientsHigh rateAdverse eventsPatient levelImpellaPropensity adjustmentHospital levelHealthcare databasesPatientsUS hospitalsHospitalPropensity scoreAssociated outcomesWide variationQuadripolar versus bipolar leads in cardiac resynchronization therapy: An analysis of the National Cardiovascular Data Registry
Hakemi EU, Doukky R, Parzynski CS, Curtis JP, Madias C. Quadripolar versus bipolar leads in cardiac resynchronization therapy: An analysis of the National Cardiovascular Data Registry. Heart Rhythm 2019, 17: 81-89. PMID: 31369870, DOI: 10.1016/j.hrthm.2019.07.028.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyNational Cardiovascular Data RegistryClinical outcomesResynchronization therapyData registryLong-term clinical outcomesStimulation rateSignificant differencesCongestive heart failure admissionsMedicaid ServicesCRT device implantsHeart failure admissionsProcedural complication rateCRT implantationElderly patientsComplication ratePrimary outcomePlacement failureDevice implantsDevice malfunctionOutcomesPatientsBipolar leadsRegistryTherapyCardiac Resynchronization Defibrillator Therapy for Nonspecific Intraventricular Conduction Delay Versus Right Bundle Branch Block
Kawata H, Bao H, Curtis JP, Minges KE, Mitiku T, Birgersdotter-Green U, Feld GK, Hsu JC. Cardiac Resynchronization Defibrillator Therapy for Nonspecific Intraventricular Conduction Delay Versus Right Bundle Branch Block. Journal Of The American College Of Cardiology 2019, 73: 3082-3099. PMID: 31221257, DOI: 10.1016/j.jacc.2019.04.025.Peer-Reviewed Original ResearchConceptsNonspecific intraventricular conduction delayRight bundle branch blockCardiac resynchronization therapyCRT-D implantationCRT-eligible patientsBundle branch blockQRS durationHazard ratioBranch blockBetter outcomesCardiac resynchronization defibrillator therapyMultivariable adjusted hazard ratiosAdjusted hazard ratioIntraventricular conduction delayCareful patient selectionEligible patientsDefibrillator therapyMultivariable adjustmentResynchronization therapyClinical outcomesPatient selectionConduction abnormalitiesRegistry dataConduction delayPatients
2015
Patterns of Institutional Review of Percutaneous Coronary Intervention Appropriateness and the Effect on Quality of Care and Clinical Outcomes
Desai NR, Parzynski CS, Krumholz HM, Minges KE, Messenger JC, Nallamothu BK, Curtis JP. Patterns of Institutional Review of Percutaneous Coronary Intervention Appropriateness and the Effect on Quality of Care and Clinical Outcomes. JAMA Internal Medicine 2015, 175: 1988. PMID: 26551259, PMCID: PMC5584388, DOI: 10.1001/jamainternmed.2015.6217.Peer-Reviewed Original ResearchComparison of Inhospital Outcomes and Hospitalization Costs of Peripheral Angioplasty and Endovascular Stenting
Panaich SS, Arora S, Patel N, Patel NJ, Lahewala S, Solanki S, Manvar S, Savani C, Jhamnani S, Singh V, Patel SV, Thakkar B, Patel A, Deshmukh A, Chothani A, Bhatt P, Savani GT, Patel J, Mavani K, Bhimani R, Tripathi B, Mohamad T, Remetz MS, Curtis JP, Attaran RR, Grines C, Mena CI, Cleman M, Forrest JK, Badheka AO. Comparison of Inhospital Outcomes and Hospitalization Costs of Peripheral Angioplasty and Endovascular Stenting. The American Journal Of Cardiology 2015, 116: 634-641. PMID: 26096999, DOI: 10.1016/j.amjcard.2015.05.031.Peer-Reviewed Original ResearchConceptsLower amputation ratesInhospital mortalityPostprocedural complicationsHospitalization costsEndovascular stentingAmputation rateUtilization Project Nationwide Inpatient Sample databaseTwo-level hierarchical multivariateNationwide Inpatient Sample databaseComposite end pointPeripheral arterial diseaseHigher hospitalization costsAppropriate International ClassificationPeripheral endovascular interventionsInhospital outcomesSecondary outcomesPeripheral angioplastyPrimary outcomeArterial diseaseClinical outcomesStudy cohortNinth RevisionPatency ratesEndovascular interventionAngioplasty
2010
The Relation Between Hospital Procedure Volume and Complications of Cardioverter-Defibrillator Implantation From the Implantable Cardioverter-Defibrillator Registry
Freeman JV, Wang Y, Curtis JP, Heidenreich PA, Hlatky MA. The Relation Between Hospital Procedure Volume and Complications of Cardioverter-Defibrillator Implantation From the Implantable Cardioverter-Defibrillator Registry. Journal Of The American College Of Cardiology 2010, 56: 1133-1139. PMID: 20863954, DOI: 10.1016/j.jacc.2010.07.007.Peer-Reviewed Original ResearchConceptsAdverse eventsProcedure volumeImplantable Cardioverter-Defibrillator RegistryHospital adverse outcomesInitial ICD implantationCardioverter-defibrillator implantationHigh-volume hospitalsLow-volume hospitalsPatients' clinical characteristicsBetter clinical outcomesHospital procedure volumeVolume-outcome relationshipNCDR ICD RegistryClinical characteristicsICD implantationICD RegistryProcedural complicationsClinical outcomesAdverse outcomesHospital characteristicsBiventricular ICDsImplant volumeHospitalRepresentative populationICD
2003
Association of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure
Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumholz HM. Association of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure. JAMA 2003, 289: 871-878. PMID: 12588271, DOI: 10.1001/jama.289.7.871.Peer-Reviewed Original ResearchConceptsSerum digoxin concentrationHigh serum digoxin concentrationsLeft ventricular ejection fractionVentricular ejection fractionHeart failureMortality rateDIG trialDigoxin therapyEjection fractionDigoxin concentrationsDepressed left ventricular systolic functionDigitalis Investigation Group trialHigher absolute mortality rateLeft ventricular systolic functionOverall mortality benefitVentricular systolic functionCause mortality ratesAbsolute mortality ratesLower mortality rateCause mortalityMultivariable adjustmentMortality benefitSystolic functionClinical outcomesSerum concentrations