2001
The Melanocortin-1 Receptor: Red Hair and Beyond
Schaffer J, Bolognia J. The Melanocortin-1 Receptor: Red Hair and Beyond. JAMA Dermatology 2001, 137: 1477-1485. PMID: 11708951, DOI: 10.1001/archderm.137.11.1477.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMelanocortin 1 receptorTransmembrane-spanning domainsG protein-coupled receptorsProtein-coupled receptorsRed hair phenotypeHuman pigmentationPigmentation phenotypesHair phenotypePheomelanin synthesisRed hairType of melaninHeterozygote effectUV-induced melanogenesisNonmelanoma skin cancerPhenotypeDecreased abilityReceptorsKey roleMelanocortin receptorsSkin cancerLociGeneticsFair skinPhysiologic variationsVariants
2000
A spontaneous murine melanoma lung metastasis comprised of host x tumor hybrids.
Chakraborty A, Sodi S, Rachkovsky M, Kolesnikova N, Platt J, Bolognia J, Pawelek J. A spontaneous murine melanoma lung metastasis comprised of host x tumor hybrids. Cancer Research 2000, 60: 2512-9. PMID: 10811133.Peer-Reviewed Original ResearchMeSH KeywordsAminopterinAnimalsAnti-Bacterial AgentsAntigens, CDAntineoplastic Combined Chemotherapy ProtocolsCell MovementChemotaxisFlow CytometryGentamicinsHypoxanthineImmunoblottingLung NeoplasmsLysosome-Associated Membrane GlycoproteinsMelanomaMembrane GlycoproteinsMiceMice, Inbred BALB CMicroscopy, ElectronMonophenol MonooxygenaseNeoplasm TransplantationPolymorphism, Restriction Fragment LengthSequence Analysis, DNAThymidineTime FactorsTumor Cells, Cultured
1999
UV Light and MSH Receptors
CHAKRABORTY A, FUNASAKA Y, SLOMINSKI A, BOLOGNIA J, SODI S, ICHIHASHI M, PAWELEK J. UV Light and MSH Receptors. Annals Of The New York Academy Of Sciences 1999, 885: 100-116. PMID: 10816644, DOI: 10.1111/j.1749-6632.1999.tb08668.x.Peer-Reviewed Original ResearchConceptsMSH receptorsSun-exposed areasAlpha-MSH receptorsSkin of miceMSH receptor activityPOMC-derived peptidesAction of UVBEffects of UVBGuinea pigsReceptor activityUVB irradiationUltraviolet B radiationReceptor productionCellular responsivenessReceptorsUVB damageB radiationSkin pigmentationUVBHuman melanocytesCutaneous melanogenesisMSHMelanin contentResultant increaseSkin
1998
Melanoma × Macrophage Fusion Hybrids Acquire Increased Melanogenesis and Metastatic Potential: Altered N‐Glycosylation as an Underlying Mechanism
SODI S, CHAKRABORTY A, PLATT J, KOLESNIKOVA N, ROSEMBLAT S, KEH‐YEN A, BOLOGNIA J, RACHKOVSKY M, ORLOW S, PAWELEK J. Melanoma × Macrophage Fusion Hybrids Acquire Increased Melanogenesis and Metastatic Potential: Altered N‐Glycosylation as an Underlying Mechanism. Pigment Cell & Melanoma Research 1998, 11: 299-309. PMID: 9877101, DOI: 10.1111/j.1600-0749.1998.tb00739.x.Peer-Reviewed Original ResearchConceptsN-glycosylationLAMP-1Parental cellsN-glycosylation inhibitorMelanoma cellsCloudman S91 cellsMetastatic potentialImportant regulatory pathwayAltered N-glycosylationMajority of hybridsParental melanoma cellsCloudman S91 melanoma cellsRegulatory pathwaysMelanosomal proteinsCloudman melanoma cellsMelanotic phenotypeSame proteinS91 melanoma cellsIncreased glycosylationPigmentary systemCell lysatesS91 cellsUnderlying mechanismCloudman cellsGel electrophoresisMelanoma × macrophage hybrids with enhanced metastatic potential
Rachkovsky M, Sodi S, Chakraborty A, Avissar Y, Bolognia J, Madison McNiff J, Platt J, Bermudes D, Pawelek J. Melanoma × macrophage hybrids with enhanced metastatic potential. Clinical & Experimental Metastasis 1998, 16: 299-312. PMID: 9626809, DOI: 10.1023/a:1006557228604.Peer-Reviewed Original ResearchConceptsHigh metastatic potentialMetastatic potentialMelanoma cellsTumor-infiltrating leukocytesParental melanoma cellsLow metastatic potentialB16F10 melanoma cellsFibroblast-conditioned mediumCloudman S91 mouse melanoma cellsMetastatic melanoma cellsS91 mouse melanoma cellsVascular invasionMetastatic melanomaPrimary tumorNormal miceMelanoma metastasesEnhanced metastasisMetastasisDistant organsUseful new modelMouse melanoma cellsHigher chemotaxisMetastatic linesHuman macrophagesTumor cells
1995
Enhancement of the depigmenting effect of hydroquinone by cystamine and buthionine sulfoximine
BOLOGNIA J, SODI S, OSBER M, PAWELEK J. Enhancement of the depigmenting effect of hydroquinone by cystamine and buthionine sulfoximine. British Journal Of Dermatology 1995, 133: 349-357. PMID: 8546987, DOI: 10.1111/j.1365-2133.1995.tb02660.x.Peer-Reviewed Original Research
1994
Effects of Ultraviolet Irradiation on the Cell Cycle
BOLOGNIA J, SODI S, CHAKRABORTY A, FARGNOLI M, PAWELEK J. Effects of Ultraviolet Irradiation on the Cell Cycle. Pigment Cell & Melanoma Research 1994, 7: 320-325. PMID: 7886005, DOI: 10.1111/j.1600-0749.1994.tb00634.x.Peer-Reviewed Original ResearchConceptsMSH receptor activityG2/M phaseReceptor activityMelanoma cellsCloudman melanoma cellsM phaseCell cycleHr post irradiationBreast carcinoma cellsG2/M accumulationReceptor binding activityEffects of UVBAccumulation of cellsGeneralized cellular responseInjury responseUVB irradiationFlow cytometryCloudman cellsCarcinoma cellsG2/MNumber of cellsM accumulationCell linesTreatmentUVB radiation
1991
Structural/functional relationships between internal and external MSH receptors: Modulation of expression in Cloudman melanoma cells by UVB radiation
Chakraborty A, Orlow S, Bolognia J, Pawelek J. Structural/functional relationships between internal and external MSH receptors: Modulation of expression in Cloudman melanoma cells by UVB radiation. Journal Of Cellular Physiology 1991, 147: 1-6. PMID: 1903794, DOI: 10.1002/jcp.1041470102.Peer-Reviewed Original Research
1989
UVB-Induced Melanogenesis May Be Mediated Through the MSH-Receptor System
Bolognia J, Murray M, Pawelek J. UVB-Induced Melanogenesis May Be Mediated Through the MSH-Receptor System. Journal Of Investigative Dermatology 1989, 92: 651-656. PMID: 2497190, DOI: 10.1111/1523-1747.ep12696836.Peer-Reviewed Original ResearchConceptsMSH receptor activityUltraviolet B radiationReceptor activityMSH binding capacityMSH receptor systemMelanin-producing melanocytesUVB-induced melanogenesisHigh-affinity receptorGuinea pig skinEffects of UVBCloudman S91 mouse melanoma cellsS91 mouse melanoma cellsFamily of peptidesCutaneous melanocytesGuinea pigsMouse melanoma cellsAffinity receptorMelanoma cellsCellular responsivenessB radiationPig skinUVB lightCutaneous melanogenesisMelanocytesMSH