Melanoma × Macrophage Fusion Hybrids Acquire Increased Melanogenesis and Metastatic Potential: Altered N‐Glycosylation as an Underlying Mechanism
SODI S, CHAKRABORTY A, PLATT J, KOLESNIKOVA N, ROSEMBLAT S, KEH‐YEN A, BOLOGNIA J, RACHKOVSKY M, ORLOW S, PAWELEK J. Melanoma × Macrophage Fusion Hybrids Acquire Increased Melanogenesis and Metastatic Potential: Altered N‐Glycosylation as an Underlying Mechanism. Pigment Cell & Melanoma Research 1998, 11: 299-309. PMID: 9877101, DOI: 10.1111/j.1600-0749.1998.tb00739.x.Peer-Reviewed Original ResearchConceptsN-glycosylationLAMP-1Parental cellsN-glycosylation inhibitorMelanoma cellsCloudman S91 cellsMetastatic potentialImportant regulatory pathwayAltered N-glycosylationMajority of hybridsParental melanoma cellsCloudman S91 melanoma cellsRegulatory pathwaysMelanosomal proteinsCloudman melanoma cellsMelanotic phenotypeSame proteinS91 melanoma cellsIncreased glycosylationPigmentary systemCell lysatesS91 cellsUnderlying mechanismCloudman cellsGel electrophoresis