Rectal suppositories of 8-methoxsalen produce fewer gastrointestinal side effects than the oral formulation
Bolognia J, Freije L, Amici L, Dellostritto J, Gasparro F. Rectal suppositories of 8-methoxsalen produce fewer gastrointestinal side effects than the oral formulation. Journal Of The American Academy Of Dermatology 1996, 35: 424-427. PMID: 8784281, DOI: 10.1016/s0190-9622(96)90609-x.Peer-Reviewed Original ResearchConceptsGastrointestinal side effectsAbdominal painRectal suppositoriesSide effectsOral formOral liquid formClinical severity scoreOpen pilot studyGroup of patientsEntire treatment periodRoute of administrationMean scoreGastrointestinal symptomsSignificant nauseaRectal formClinical efficacyPsoriasis vulgarisPlasma levelsSeverity scoreTreatment periodOral ingestionSuppository formOral formulationPatientsNausea