Hypercortisolemia Is Associated with Severity of Bone Loss and Depression in Hypothalamic Amenorrhea and Anorexia Nervosa
Lawson EA, Donoho D, Miller KK, Misra M, Meenaghan E, Lydecker J, Wexler T, Herzog DB, Klibanski A. Hypercortisolemia Is Associated with Severity of Bone Loss and Depression in Hypothalamic Amenorrhea and Anorexia Nervosa. The Journal Of Clinical Endocrinology & Metabolism 2009, 94: 4710-4716. PMID: 19837921, PMCID: PMC2795653, DOI: 10.1210/jc.2009-1046.Peer-Reviewed Original ResearchConceptsBone mineral densityDual-energy X-ray absorptiometryHypothalamic amenorrheaHAM-D scoresLow bone densityBone lossAnorexia nervosaCortisol levelsBone densityMood disturbanceFunctional hypothalamic amenorrheaClinical Research CenterHamilton Rating ScaleCross-sectional studyX-ray absorptiometrySignificant hypercortisolemiaCushing's diseaseAverage cortisol levelsMineral densityHypercortisolemiaCortisol dysregulationSerum samplesRating ScalePotential mediatorsDepression