2024
The relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives
Arutiunian V, Santhosh M, Neuhaus E, Borland H, Tompkins C, Bernier R, Bookheimer S, Dapretto M, Gupta A, Jack A, Jeste S, McPartland J, Naples A, Van Horn J, Pelphrey K, Webb S. The relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives. Molecular Autism 2024, 15: 19. PMID: 38711098, PMCID: PMC11075235, DOI: 10.1186/s13229-024-00598-1.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderElevated gamma powerLow language skillsGamma powerResponses to speech stimuliLanguage skillsLanguage functionFirst-degree relativesSpectrum disorderClinical Evaluation of Language FundamentalsCo-occurring language impairmentSpeech stimuliCortical gamma-band oscillationsHigh gamma powerSex-balanced sampleGamma-band oscillationsSample of participantsNonverbal IQLanguage impairmentASD participantsTD controlsNeural profilesAutism phenotypeTD groupLanguage Fundamentals
2023
Frontal EEG alpha asymmetry in youth with autism: Sex differences and social–emotional correlates
Neuhaus E, Santhosh M, Kresse A, Aylward E, Bernier R, Bookheimer S, Jeste S, Jack A, McPartland J, Naples A, Van Horn J, Pelphrey K, Webb S, Network A. Frontal EEG alpha asymmetry in youth with autism: Sex differences and social–emotional correlates. Autism Research 2023, 16: 2364-2377. PMID: 37776030, PMCID: PMC10840952, DOI: 10.1002/aur.3032.Peer-Reviewed Original ResearchConceptsAutistic youthFrontal alpha powerMaternal depression historyIndividual differencesExternalizing behaviorsAlpha powerFrontal EEG alpha asymmetrySocial-emotional correlatesDepression historyEEG alpha asymmetryMental health behaviorsModel of riskAffective styleAutism featuresInternalizing symptomsASD diagnosisAlpha asymmetryAutistic femalesBehavioral indicesLevels of analysisAutistic malesEEG markersGroup differencesParticipant groupsASDEvaluation of clinical assessments of social abilities for use in autism clinical trials by the autism biomarkers consortium for clinical trials
Faja S, Sabatos‐DeVito M, Sridhar A, Kuhn J, Nikolaeva J, Sugar C, Webb S, Bernier R, Sikich L, Hellemann G, Senturk D, Naples A, Shic F, Levin A, Seow H, Dziura J, Jeste S, Chawarska K, Nelson C, Dawson G, McPartland J, Trials A. Evaluation of clinical assessments of social abilities for use in autism clinical trials by the autism biomarkers consortium for clinical trials. Autism Research 2023, 16: 981-996. PMID: 36929131, PMCID: PMC10192100, DOI: 10.1002/aur.2905.Peer-Reviewed Original Research
2020
Neurologic Characterization of Craniosynostosis: Can Direct Brain Recordings Predict Language Development?
Wu R, Nie J, Abraham P, Halligan T, Gabrick K, Peck CJ, Sawh-Martinez R, Steinbacher DM, Alperovich M, McPartland J, Persing JA. Neurologic Characterization of Craniosynostosis: Can Direct Brain Recordings Predict Language Development? Journal Of Craniofacial Surgery 2020, 32: 78-82. PMID: 32941205, DOI: 10.1097/scs.0000000000007004.Peer-Reviewed Original ResearchConceptsNeural responsesLanguage deficitsLanguage developmentERP assessmentMetopic patientsMismatch negativity waveLarger negative amplitudesLong-term cognitionLanguage achievementCognitive outcomesMMNBrain recordingsInfant developmentBayley ScalesNegative amplitudeBSID scoresEEG testingBSIDDeficitsElectroencephalogramNeurocognitionCognitionSpeechStimuliYears of ageN400 amplitude, latency, and variability reflect temporal integration of beat gesture and pitch accent during language processing
Morett LM, Landi N, Irwin J, McPartland JC. N400 amplitude, latency, and variability reflect temporal integration of beat gesture and pitch accent during language processing. Brain Research 2020, 1747: 147059. PMID: 32818527, PMCID: PMC7493208, DOI: 10.1016/j.brainres.2020.147059.Peer-Reviewed Original ResearchNeural responsivity to social rewards in autistic female youth
Lawrence KE, Hernandez LM, Eilbott J, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, Geschwind DH, McPartland JC, Nelson CA, Webb SJ, Pelphrey KA, Bookheimer SY, Dapretto M. Neural responsivity to social rewards in autistic female youth. Translational Psychiatry 2020, 10: 178. PMID: 32488083, PMCID: PMC7266816, DOI: 10.1038/s41398-020-0824-8.Peer-Reviewed Original ResearchConceptsImplicit learning taskSocial rewardsAutistic girlsAutistic boysLearning taskSocial reward processingSocial reward systemFemale youthPrevious neuroimaging studiesFunctional magnetic resonanceLateral frontal cortexSocial stimuliNeural responsivityReward processingSocial motivationRewarding stimuliAnterior insulaGreater activityNeural activationNeuroimaging studiesPotential sex differencesRewarding natureSalience detectionAutistic femalesBehavioral evidenceSex Differences in Functional Connectivity of the Salience, Default Mode, and Central Executive Networks in Youth with ASD
Lawrence KE, Hernandez LM, Bowman HC, Padgaonkar NT, Fuster E, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, Geschwind DH, McPartland JC, Nelson CA, Webb SJ, Pelphrey KA, Green SA, Bookheimer SY, Dapretto M, Consortium G. Sex Differences in Functional Connectivity of the Salience, Default Mode, and Central Executive Networks in Youth with ASD. Cerebral Cortex 2020, 30: 5107-5120. PMID: 32350530, PMCID: PMC7391269, DOI: 10.1093/cercor/bhaa105.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCentral executive networkDefault mode networkFunctional connectivitySalience networkExecutive networkSymptomatology of ASDGreater functional connectivitySex-related biological factorsSample of girlsSN functional connectivitySex differencesAltered functional connectivityASD exhibitNeurotypical individualsNeurocognitive networksTypical developmentNeural mechanismsSpectrum disorderDefault modeMode networkParticipant sexMale samplesYouthGirlsHigher Depressive Symptoms Predict Lower Social Adaptive Functioning in Children and Adolescents with ASD
Duan S, Lee M, Wolf J, Naples AJ, McPartland JC. Higher Depressive Symptoms Predict Lower Social Adaptive Functioning in Children and Adolescents with ASD. Journal Of Clinical Child & Adolescent Psychology 2020, 51: 203-210. PMID: 32347746, DOI: 10.1080/15374416.2020.1750020.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAdaptive functioningDepressive symptomsHigher depressive symptomsDaily living skillsSocial adaptiveTypical developmentSocial skillsSpectrum disorderLiving skillsSocial domainsLower functioningAdaptive functionAdolescentsFunctioningDepressive symptomatologyChildrenDifferent domainsSkillsIQSymptomsPresent studyYears of ageImaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity
Hernandez LM, Lawrence KE, Padgaonkar NT, Inada M, Hoekstra JN, Lowe JK, Eilbott J, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, McPartland JC, Webb SJ, Pelphrey KA, Green SA, Geschwind DH, Bookheimer SY, Dapretto M. Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity. Translational Psychiatry 2020, 10: 82. PMID: 32127526, PMCID: PMC7054353, DOI: 10.1038/s41398-020-0750-9.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNeurotypical malesOXTR variantsBrain connectivityNeurobiological mechanismsPrefrontal cortexFunctional connectivityNetwork resting-state functional connectivityManifestation of ASDReward-related brain regionsResting-state functional connectivityBrain areasGreater functional connectivityPrefrontal brain areasFemale protective effectSubcortical brain areasSpectrum disorderMotor learningOXTR geneDiagnosis relateHigh OXTRBrain regionsGenetic riskSubcortical regionsSex differencesLight-Adapted Electroretinogram Differences in Autism Spectrum Disorder
Constable PA, Ritvo ER, Ritvo AR, Lee IO, McNair ML, Stahl D, Sowden J, Quinn S, Skuse DH, Thompson DA, McPartland JC. Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2020, 50: 2874-2885. PMID: 32034650, DOI: 10.1007/s10803-020-04396-5.Peer-Reviewed Original Research
2019
Autistic and alexithymic traits modulate distinct aspects of face perception
Desai A, Foss-Feig JH, Naples AJ, Coffman M, Trevisan DA, McPartland JC. Autistic and alexithymic traits modulate distinct aspects of face perception. Brain And Cognition 2019, 137: 103616. PMID: 31734588, PMCID: PMC6880874, DOI: 10.1016/j.bandc.2019.103616.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderEvent-related potentialsAlexithymic traitsAutistic traitsAtypical face processingEmotion recognition impairmentsEmotion decodingEmotion perceptionEmotional facesFace perceptionFace processingPerceptual processingNeural indicesNeutral facesStructural encodingRecognition impairmentEmotion recognitionERP componentsSpectrum disorderTemporal sensitivityGrouping factorsDistinct aspectsIndividual variabilityAlexithymiaDistinct contributionsA Meta-Analysis on the Relationship Between Interoceptive Awareness and Alexithymia: Distinguishing Interoceptive Accuracy and Sensibility
Trevisan DA, Altschuler MR, Bagdasarov A, Carlos C, Duan S, Hamo E, Kala S, McNair ML, Parker T, Stahl D, Winkelman T, Zhou M, McPartland JC. A Meta-Analysis on the Relationship Between Interoceptive Awareness and Alexithymia: Distinguishing Interoceptive Accuracy and Sensibility. Journal Of Psychopathology And Clinical Science 2019, 128: 765-776. PMID: 31380655, DOI: 10.1037/abn0000454.Peer-Reviewed Original ResearchAutism spectrum traits predict higher social psychological skill
Gollwitzer A, Martel C, McPartland JC, Bargh JA. Autism spectrum traits predict higher social psychological skill. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 19245-19247. PMID: 31501348, PMCID: PMC6765248, DOI: 10.1073/pnas.1911460116.Peer-Reviewed Original ResearchConceptsSocial psychological phenomenaPsychological skillsPsychological phenomenaSocial cognitive skillsAutism spectrum traitsSocial cognitionPerception deficitsAutism spectrumParticipants' accuracySocial phenomenaIndividual intentionsPast researchSecond studySkillsParticipantsIntentionEmotionsCognitionTraitsDifferent formsDeficitsThoughtUnderliesDivergent typesPoor accuracySelf-reported social impairments predict depressive disorder in adults with autism spectrum disorder
Day TC, McNaughton KA, Naples AJ, McPartland JC. Self-reported social impairments predict depressive disorder in adults with autism spectrum disorder. Autism 2019, 24: 297-306. PMID: 31238701, PMCID: PMC6930361, DOI: 10.1177/1362361319857375.Peer-Reviewed Original ResearchConceptsAutism spectrum disorder groupAutism spectrum disorderAutism symptom severitySocial impairmentSpectrum disorderDisorder groupCo-occurring depressive disorderCognitive abilitiesTypical developmentSymptom severityTypical development groupCo-occurring psychiatric conditionsHigher intelligence quotientCommon co-occurring disordersCo-occurring disordersDepressive disorderCognitive testsDepressive disorder groupLongitudinal designIntelligence quotientStandardized psychiatric interviewPsychiatric interviewPsychiatric conditionsImpairmentAdultsMethodological considerations in the use of Noldus EthoVision XT video tracking of children with autism in multi-site studies
Sabatos-DeVito M, Murias M, Dawson G, Howell T, Yuan A, Marsan S, Bernier RA, Brandt CA, Chawarska K, Dzuira JD, Faja S, Jeste SS, Naples A, Nelson CA, Shic F, Sugar CA, Webb SJ, McPartland JC, Trials A. Methodological considerations in the use of Noldus EthoVision XT video tracking of children with autism in multi-site studies. Biological Psychology 2019, 146: 107712. PMID: 31163191, PMCID: PMC7334026, DOI: 10.1016/j.biopsycho.2019.05.012.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderBehavioral testing paradigmsVariety of behaviorsSpectrum disorderLaboratory-based observationsPlay interactionsBehavioral paradigmsBehavioral manifestationsSocial engagementMulti-site studyBehavioral phenotypesTesting paradigmTracking studyHuman movement patternsMethodological considerationsMovement patternsTranslational biomarkersParadigmChildrenAutismTracking dataVideo trackingRodent modelsContextRole of genetics
2018
Neurophysiological correlates of holistic face processing in adolescents with and without autism spectrum disorder
Naumann S, Senftleben U, Santhosh M, McPartland J, Webb SJ. Neurophysiological correlates of holistic face processing in adolescents with and without autism spectrum disorder. Journal Of Neurodevelopmental Disorders 2018, 10: 27. PMID: 30165814, PMCID: PMC6118009, DOI: 10.1186/s11689-018-9244-y.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderMooney stimuliHolistic processingHolistic faceSpectrum disorderIQ-matched neurotypical controlsFace processing strategiesGamma-band activitySlow response timeMooney imagesFace processingASD engageASD groupERP componentsElectroencephalography (EEG) correlatesNeurophysiological correlatesNeurotypical controlsTemporal processingEarly processingP1 amplitudeNeural systemsProcessing strategiesGamma activityStimuliP1 latencyResting-state alpha power is selectively associated with autistic traits reflecting behavioral rigidity
Carter Leno V, Tomlinson SB, Chang SA, Naples AJ, McPartland JC. Resting-state alpha power is selectively associated with autistic traits reflecting behavioral rigidity. Scientific Reports 2018, 8: 11982. PMID: 30097597, PMCID: PMC6086866, DOI: 10.1038/s41598-018-30445-2.Peer-Reviewed Original ResearchElectrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in autism spectrum disorder?
Foss-Feig JH, Stavropoulos KKM, McPartland JC, Wallace MT, Stone WL, Key AP. Electrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in autism spectrum disorder? Developmental Neuropsychology 2018, 43: 109-122. PMID: 29436853, PMCID: PMC5972824, DOI: 10.1080/87565641.2017.1365869.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAuditory gap detectionSpectrum disorderP2 event-related potential (ERP) componentsEvent-related potential componentGap detectionLanguage-related impairmentsAuditory processing deficitsElectrophysiological responsesProcessing deficitsAuditory stimuliNeural responsesAuditory inputASD biomarkersSilent gapsPotential componentsCommunication alterationsTemporal aspectsDeficitsAmplitude reductionDisordersStimuliSensory symptomsTreatment responseImpairment
2017
Modulation of reward in a live social context as revealed through interactive social neuroscience
Rolison MJ, Naples A, Rutherford HJV, McPartland J. Modulation of reward in a live social context as revealed through interactive social neuroscience. Social Neuroscience 2017, 13: 416-428. PMID: 28586261, PMCID: PMC6072262, DOI: 10.1080/17470919.2017.1339635.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial neuroscience researchAutistic traitsLive interactionSocial neuroscienceReward processingNeuroscience researchReward processing deficitsReward processing mechanismsPathology of ASDModulation of rewardProcessing deficitsHuman partnerNeural sensitivityNeuroscience techniquesSpectrum disorderProcessing mechanismsMixed findingsSocial interactionDevelopmental disordersHuman competitorsEEG resultsSocial contextInconsistent findingsTreasure hunt gameSocial Media Use, Friendship Quality, and the Moderating Role of Anxiety in Adolescents with Autism Spectrum Disorder
van Schalkwyk GI, Marin CE, Ortiz M, Rolison M, Qayyum Z, McPartland JC, Lebowitz ER, Volkmar FR, Silverman WK. Social Media Use, Friendship Quality, and the Moderating Role of Anxiety in Adolescents with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2017, 47: 2805-2813. PMID: 28616856, PMCID: PMC6688174, DOI: 10.1007/s10803-017-3201-6.Peer-Reviewed Original ResearchConceptsFriendship qualityAnxiety levelsSocial media useHigher friendship qualityComplex social informationAutism spectrum disorderMedia useSpectrum disorderSocial informationModerating RoleSocial mediaSocial engagementASDOffline social activitiesAnxietyAdolescentsSignificant anxietyComparison controlsSocial activities