2024
Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder
Newman B, Jacokes Z, Venkadesh S, Webb S, Kleinhans N, McPartland J, Druzgal T, Pelphrey K, Van Horn J, Consortium F. Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder. PLOS ONE 2024, 19: e0301964. PMID: 38630783, PMCID: PMC11023574, DOI: 10.1371/journal.pone.0301964.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial Communication QuestionnaireSpectrum disorderCharacteristics of autism spectrum disorderAssociated with higher scoresEtiology of autism spectrum disorderMagnetic resonance imagingNeurotypical participantsWhite matter skeletonCommunication QuestionnaireBehavioral functionsFunctional connectivityT1w/T2w ratioNeuronal differencesStructural connectivityAdolescent participantsHigher scoresConduction velocityCortexExtracellular waterDisordersResonance imagingDiffusion MRI techniques
2022
A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth
Horien C, Greene A, Shen X, Fortes D, Brennan-Wydra E, Banarjee C, Foster R, Donthireddy V, Butler M, Powell K, Vernetti A, Mandino F, O'Connor D, Lake E, McPartland J, Volkmar F, Chun M, Chawarska K, Rosenberg M, Scheinost D, Constable R. A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth. Cerebral Cortex 2022, 33: 6320-6334. PMID: 36573438, PMCID: PMC10183743, DOI: 10.1093/cercor/bhac506.Peer-Reviewed Original ResearchConceptsAttention taskAttentional stateConnectome-based predictive modelingNeurodiverse conditionsSustained attention taskAttention network modelSample of youthNeurotypical participantsSustained attentionBrain correlatesNeurobiological correlatesAttention networkIndividual participantsSeparate samplesYouthParticipantsHead motionTaskCorrelatesAttentionAutismConfoundsNetwork modelGeneralizesHealthcare settingsNeural correlates of eye contact and social function in autism spectrum disorder
Hirsch J, Zhang X, Noah J, Dravida S, Naples A, Tiede M, Wolf J, McPartland J. Neural correlates of eye contact and social function in autism spectrum disorder. PLOS ONE 2022, 17: e0265798. PMID: 36350848, PMCID: PMC9645655, DOI: 10.1371/journal.pone.0265798.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderDorsal parietal regionsNeural correlatesEye contactLive eyesNeural responsesSpectrum disorderAutism Diagnostic Observation ScheduleUnderlying neural correlatesSocial Responsiveness ScaleGold standard measureCentral diagnostic criterionDiagnostic criteriaDiagnostic biomarkersSRS-2ADOS-2Responsiveness ScaleObservation ScheduleParietal regionsPupillometry dataNeural systemsEyesNatural interactionDisordersCorrelates
2020
Neurologic Characterization of Craniosynostosis: Can Direct Brain Recordings Predict Language Development?
Wu R, Nie J, Abraham P, Halligan T, Gabrick K, Peck CJ, Sawh-Martinez R, Steinbacher DM, Alperovich M, McPartland J, Persing JA. Neurologic Characterization of Craniosynostosis: Can Direct Brain Recordings Predict Language Development? Journal Of Craniofacial Surgery 2020, 32: 78-82. PMID: 32941205, DOI: 10.1097/scs.0000000000007004.Peer-Reviewed Original ResearchConceptsNeural responsesLanguage deficitsLanguage developmentERP assessmentMetopic patientsMismatch negativity waveLarger negative amplitudesLong-term cognitionLanguage achievementCognitive outcomesMMNBrain recordingsInfant developmentBayley ScalesNegative amplitudeBSID scoresEEG testingBSIDDeficitsElectroencephalogramNeurocognitionCognitionSpeechStimuliYears of ageN400 amplitude, latency, and variability reflect temporal integration of beat gesture and pitch accent during language processing
Morett LM, Landi N, Irwin J, McPartland JC. N400 amplitude, latency, and variability reflect temporal integration of beat gesture and pitch accent during language processing. Brain Research 2020, 1747: 147059. PMID: 32818527, PMCID: PMC7493208, DOI: 10.1016/j.brainres.2020.147059.Peer-Reviewed Original ResearchSex Differences in Functional Connectivity of the Salience, Default Mode, and Central Executive Networks in Youth with ASD
Lawrence KE, Hernandez LM, Bowman HC, Padgaonkar NT, Fuster E, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, Geschwind DH, McPartland JC, Nelson CA, Webb SJ, Pelphrey KA, Green SA, Bookheimer SY, Dapretto M, Consortium G. Sex Differences in Functional Connectivity of the Salience, Default Mode, and Central Executive Networks in Youth with ASD. Cerebral Cortex 2020, 30: 5107-5120. PMID: 32350530, PMCID: PMC7391269, DOI: 10.1093/cercor/bhaa105.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCentral executive networkDefault mode networkFunctional connectivitySalience networkExecutive networkSymptomatology of ASDGreater functional connectivitySex-related biological factorsSample of girlsSN functional connectivitySex differencesAltered functional connectivityASD exhibitNeurotypical individualsNeurocognitive networksTypical developmentNeural mechanismsSpectrum disorderDefault modeMode networkParticipant sexMale samplesYouthGirlsImaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity
Hernandez LM, Lawrence KE, Padgaonkar NT, Inada M, Hoekstra JN, Lowe JK, Eilbott J, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, McPartland JC, Webb SJ, Pelphrey KA, Green SA, Geschwind DH, Bookheimer SY, Dapretto M. Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity. Translational Psychiatry 2020, 10: 82. PMID: 32127526, PMCID: PMC7054353, DOI: 10.1038/s41398-020-0750-9.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNeurotypical malesOXTR variantsBrain connectivityNeurobiological mechanismsPrefrontal cortexFunctional connectivityNetwork resting-state functional connectivityManifestation of ASDReward-related brain regionsResting-state functional connectivityBrain areasGreater functional connectivityPrefrontal brain areasFemale protective effectSubcortical brain areasSpectrum disorderMotor learningOXTR geneDiagnosis relateHigh OXTRBrain regionsGenetic riskSubcortical regionsSex differences
2019
Autistic and alexithymic traits modulate distinct aspects of face perception
Desai A, Foss-Feig JH, Naples AJ, Coffman M, Trevisan DA, McPartland JC. Autistic and alexithymic traits modulate distinct aspects of face perception. Brain And Cognition 2019, 137: 103616. PMID: 31734588, PMCID: PMC6880874, DOI: 10.1016/j.bandc.2019.103616.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderEvent-related potentialsAlexithymic traitsAutistic traitsAtypical face processingEmotion recognition impairmentsEmotion decodingEmotion perceptionEmotional facesFace perceptionFace processingPerceptual processingNeural indicesNeutral facesStructural encodingRecognition impairmentEmotion recognitionERP componentsSpectrum disorderTemporal sensitivityGrouping factorsDistinct aspectsIndividual variabilityAlexithymiaDistinct contributions
2018
Neurophysiological correlates of holistic face processing in adolescents with and without autism spectrum disorder
Naumann S, Senftleben U, Santhosh M, McPartland J, Webb SJ. Neurophysiological correlates of holistic face processing in adolescents with and without autism spectrum disorder. Journal Of Neurodevelopmental Disorders 2018, 10: 27. PMID: 30165814, PMCID: PMC6118009, DOI: 10.1186/s11689-018-9244-y.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderMooney stimuliHolistic processingHolistic faceSpectrum disorderIQ-matched neurotypical controlsFace processing strategiesGamma-band activitySlow response timeMooney imagesFace processingASD engageASD groupERP componentsElectroencephalography (EEG) correlatesNeurophysiological correlatesNeurotypical controlsTemporal processingEarly processingP1 amplitudeNeural systemsProcessing strategiesGamma activityStimuliP1 latencyResting-state alpha power is selectively associated with autistic traits reflecting behavioral rigidity
Carter Leno V, Tomlinson SB, Chang SA, Naples AJ, McPartland JC. Resting-state alpha power is selectively associated with autistic traits reflecting behavioral rigidity. Scientific Reports 2018, 8: 11982. PMID: 30097597, PMCID: PMC6086866, DOI: 10.1038/s41598-018-30445-2.Peer-Reviewed Original Research
2017
Modulation of reward in a live social context as revealed through interactive social neuroscience
Rolison MJ, Naples A, Rutherford HJV, McPartland J. Modulation of reward in a live social context as revealed through interactive social neuroscience. Social Neuroscience 2017, 13: 416-428. PMID: 28586261, PMCID: PMC6072262, DOI: 10.1080/17470919.2017.1339635.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial neuroscience researchAutistic traitsLive interactionSocial neuroscienceReward processingNeuroscience researchReward processing deficitsReward processing mechanismsPathology of ASDModulation of rewardProcessing deficitsHuman partnerNeural sensitivityNeuroscience techniquesSpectrum disorderProcessing mechanismsMixed findingsSocial interactionDevelopmental disordersHuman competitorsEEG resultsSocial contextInconsistent findingsTreasure hunt gameEvent-related potentials index neural response to eye contact
Naples AJ, Wu J, Mayes LC, McPartland JC. Event-related potentials index neural response to eye contact. Biological Psychology 2017, 127: 18-24. PMID: 28396215, PMCID: PMC5593764, DOI: 10.1016/j.biopsycho.2017.04.006.Peer-Reviewed Original ResearchConceptsBrain responsesNeural markersGreater brain responseSocial cognitionERP componentsAutistic traitsIndividual differencesParticipants' gazeNeural responsesCo-registered EEGBrain activityEye contactNormative scoresMouth movementsMeaningful variabilitySocial functionReciprocal gazeSocial performanceGazeComponent differencesN170CognitionFaceP300ParticipantsSearching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders
Foss-Feig JH, Adkinson BD, Ji JL, Yang G, Srihari VH, McPartland JC, Krystal JH, Murray JD, Anticevic A. Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders. Biological Psychiatry 2017, 81: 848-861. PMID: 28434615, PMCID: PMC5436134, DOI: 10.1016/j.biopsych.2017.03.005.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderFunctional magnetic resonance imagingRecent theoretical accountsEarly course schizophreniaNeurodevelopmental disordersPharmacological challenge studiesNeural correlatesNeuroscience literatureTheoretical accountsNeural circuitryTheoretical neuroscienceNoninvasive neuroimagingBehavioral dysfunctionFuture researchNeuropsychiatric conditionsComputational modelSchizophreniaProton magnetic resonance spectroscopyDisordersInhibition imbalanceMagnetic resonance imagingDistinct modalitiesPoint of convergenceInhibition balanceThe Severity of Deformity in Metopic Craniosynostosis Is Correlated with the Degree of Neurologic Dysfunction
Yang JF, Brooks ED, Hashim PW, Reuman HS, Travieso R, Terner J, Mayes LC, Steinbacher DM, Persing JA, McPartland JC. The Severity of Deformity in Metopic Craniosynostosis Is Correlated with the Degree of Neurologic Dysfunction. Plastic & Reconstructive Surgery 2017, 139: 442-447. PMID: 28121881, DOI: 10.1097/prs.0000000000002952.Peer-Reviewed Original ResearchConceptsSevere metopic synostosisMetopic synostosisControl infantsNeurologic dysfunctionAuditory processingCLINICAL QUESTION/LEVELFrontal scalp regionsSurgical treatment recommendationsLeft frontal lobeAbnormal auditory processingSeverity of deformityScalp regionsDegree of severityNeurologic riskPreoperative patientsTreatment recommendationsFrontal cortexSevere formPatientsFrontal lobeLanguage dysfunctionCraniosynostosis patientsMild formDysfunctionInfants
2016
Autistic traits modulate conscious and nonconscious face perception
Stavropoulos KK, Viktorinova M, Naples A, Foss-Feig J, McPartland JC. Autistic traits modulate conscious and nonconscious face perception. Social Neuroscience 2016, 13: 40-51. PMID: 27750521, PMCID: PMC6194504, DOI: 10.1080/17470919.2016.1248788.Peer-Reviewed Original ResearchConceptsEvent-related potentialsAutism spectrum disorderAutistic traitsEmotional facesFace perceptionAutism QuotientAQ scoresShorter N170 latenciesBroader autism phenotypeHigher AQ scoresAutistic-like traitsEmotion perceptionN170 latencyNonconscious perceptionNeural underpinningsERP componentsAutism phenotypeConscious awarenessSocial perceptionSocial impairmentNeural responsesSpectrum disorderP300 amplitudeCore featuresSubclinical levels
2015
Diminished social reward anticipation in the broad autism phenotype as revealed by event-related brain potentials
Cox A, Kohls G, Naples AJ, Mukerji CE, Coffman MC, Rutherford HJ, Mayes LC, McPartland JC. Diminished social reward anticipation in the broad autism phenotype as revealed by event-related brain potentials. Social Cognitive And Affective Neuroscience 2015, 10: 1357-1364. PMID: 25752905, PMCID: PMC4590535, DOI: 10.1093/scan/nsv024.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAutistic traitsReward anticipationReward responsivenessEvent-related brain potentialsSocial reward responsivenessSocial reward anticipationSocial motivation theoryBroader autism phenotypeSocial communication problemsIncentive delay taskMotivated attentionReward sensitivityBrain potentialsAutism phenotypeReward processingTypical functioningP3 responseP3 componentNeural responsesMotivation theorySpectrum disorderSocial informationSocial interactionPrior findingsInteractive social neuroscience to study autism spectrum disorder.
Rolison MJ, Naples AJ, McPartland JC. Interactive social neuroscience to study autism spectrum disorder. The Yale Journal Of Biology And Medicine 2015, 88: 17-24. PMID: 25745371, PMCID: PMC4345534.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAutism spectrum disorderSocial neuroscienceSpectrum disorderNeuropathology of ASDNeuroscience approachNeuroscience methodsNeural processesSocial difficultiesNeural mechanismsCommunication deficitsASD researchContext of interactionNeuroscience researchSocial interactionBrain regionsNeuroscienceDifficultiesLimited insightDisordersContextBrainDeficitsResearchIndividualsPeopleConnectivity in Context: Emphasizing Neurodevelopment in Autism Spectrum Disorder
McPartland JC, Jeste SS. Connectivity in Context: Emphasizing Neurodevelopment in Autism Spectrum Disorder. Biological Psychiatry 2015, 77: 772-774. PMID: 25843335, DOI: 10.1016/j.biopsych.2015.02.033.Peer-Reviewed Original ResearchDirect Brain Recordings Reveal Impaired Neural Function in Infants With Single-Suture Craniosynostosis
Hashim PW, Brooks ED, Persing JA, Reuman H, Naples A, Travieso R, Terner J, Steinbacher D, Landi N, Mayes L, McPartland JC. Direct Brain Recordings Reveal Impaired Neural Function in Infants With Single-Suture Craniosynostosis. Journal Of Craniofacial Surgery 2015, 26: 60-63. PMID: 25534054, DOI: 10.1097/scs.0000000000001195.Peer-Reviewed Original ResearchConceptsEvent-related potentialsN450 componentNeural processingSingle-suture craniosynostosisAuditory processingLong-term cognitive functioningSpeech sound processingPresentation of speechP150 amplitudesCognitive functioningLanguage delayLearning DisabilitiesSound processingCortical activityNoninvasive neuroimagingDevelopmental onsetCurrent studyBrain developmentNeural functionProcessingSuch adverse outcomesMonths of ageSurgical treatmentAdverse outcomesElectrophysiological assessment
2014
A computer-generated animated face stimulus set for psychophysiological research
Naples A, Nguyen-Phuc A, Coffman M, Kresse A, Faja S, Bernier R, McPartland JC. A computer-generated animated face stimulus set for psychophysiological research. Behavior Research Methods 2014, 47: 562-570. PMID: 25028164, PMCID: PMC4297263, DOI: 10.3758/s13428-014-0491-x.Peer-Reviewed Original ResearchConceptsFace stimuliHigh-level visual propertiesLow-level image propertiesDifferent face categoriesDynamic face stimuliEarly brain responsesEvent-related potentialsLow-level visual featuresFace perceptionFace categoriesStructural encodingDynamic facesNaturalistic videosVisual processingSocial perceptionBrain responsesNeutral movementsGrayscale facesAffective movementsHuman faceVisual propertiesPsychophysiological researchVisual featuresLow-level image characteristicsImpossible movements