2024
11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults
Matuskey D, Yang Y, Naganawa M, Koohsari S, Toyonaga T, Gravel P, Pittman B, Torres K, Pisani L, Finn C, Cramer-Benjamin S, Herman N, Rosenthal L, Franke C, Walicki B, Esterlis I, Skosnik P, Radhakrishnan R, Wolf J, Nabulsi N, Ropchan J, Huang Y, Carson R, Naples A, McPartland J. 11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults. Molecular Psychiatry 2024, 1-7. PMID: 39367053, DOI: 10.1038/s41380-024-02776-2.Peer-Reviewed Original ResearchPositron emission tomographySynaptic densityAutistic adultsBrain regionsAutistic featuresClinical phenotype of autismNon-autistic participantsPhenotype of autismNon-autistic individualsRelationship to clinical characteristicsSynaptic vesicle glycoprotein 2AAssociated with clinical measuresPost-mortem studiesPositron emission tomography scanPrefrontal cortexClinician ratingsAutism groupNeural basisBrain areasNeural processesBetween-group differencesVolumetric differencesBinding potentialDensity of synapsesAutism
2020
Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity
Hernandez LM, Lawrence KE, Padgaonkar NT, Inada M, Hoekstra JN, Lowe JK, Eilbott J, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, McPartland JC, Webb SJ, Pelphrey KA, Green SA, Geschwind DH, Bookheimer SY, Dapretto M. Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity. Translational Psychiatry 2020, 10: 82. PMID: 32127526, PMCID: PMC7054353, DOI: 10.1038/s41398-020-0750-9.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNeurotypical malesOXTR variantsBrain connectivityNeurobiological mechanismsPrefrontal cortexFunctional connectivityNetwork resting-state functional connectivityManifestation of ASDReward-related brain regionsResting-state functional connectivityBrain areasGreater functional connectivityPrefrontal brain areasFemale protective effectSubcortical brain areasSpectrum disorderMotor learningOXTR geneDiagnosis relateHigh OXTRBrain regionsGenetic riskSubcortical regionsSex differences
2011
Enhanced neural responses to rule violation in children with autism: A comparison to social exclusion
Bolling DZ, Pitskel NB, Deen B, Crowley MJ, McPartland JC, Kaiser MD, Vander Wyk BC, Wu J, Mayes LC, Pelphrey KA. Enhanced neural responses to rule violation in children with autism: A comparison to social exclusion. Developmental Cognitive Neuroscience 2011, 1: 280-294. PMID: 21743819, PMCID: PMC3129780, DOI: 10.1016/j.dcn.2011.02.002.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderFunctional magnetic resonance imagingRight insulaVentral anterior cingulate cortexSocial exclusionAtypical neural networksRule violationsBall-tossing gameDorsal prefrontal cortexRepetitive behavior patternsAnterior cingulate cortexASD groupNeural correlatesBrain responsesSocial impairmentNeural responsesCharacteristic deficitsSpectrum disorderNeurobiological differencesPrefrontal cortexCingulate cortexFunctional connectivityComparable gamesInsulaGroup differences
2010
Dissociable brain mechanisms for processing social exclusion and rule violation
Bolling DZ, Pitskel NB, Deen B, Crowley MJ, McPartland JC, Mayes LC, Pelphrey KA. Dissociable brain mechanisms for processing social exclusion and rule violation. NeuroImage 2010, 54: 2462-2471. PMID: 20974272, PMCID: PMC3006641, DOI: 10.1016/j.neuroimage.2010.10.049.Peer-Reviewed Original ResearchMeSH KeywordsBrainCerebral CortexComputer GraphicsData Interpretation, StatisticalFemaleGames, ExperimentalHumansImage Processing, Computer-AssistedInterpersonal RelationsMagnetic Resonance ImagingMaleNerve NetNeural PathwaysPsychophysicsRejection, PsychologySocial EnvironmentSocial PerceptionYoung AdultConceptsVentral anterior cingulate cortexBrain regionsMagnetic resonance imaging studyDifferential functional connectivityResonance imaging studyFunctional magnetic resonance imaging studyAnterior cingulate cortexCingulate cortex activityMiddle temporal gyrusLateral parietal cortexVentrolateral prefrontal cortexCingulate cortexParietal cortexImaging studiesCortex activityFunctional connectivityTemporal gyrusPrefrontal cortexPosterior cingulate cortex activityActivation patternsCortexBrain mechanismsFunctional dissociationVirtual ball-tossing gameNeural systems
2002
Neurocognitive Function and Joint Attention Ability in Young Children with Autism Spectrum Disorder Versus Developmental Delay
Dawson G, Munson J, Estes A, Osterling J, McPartland J, Toth K, Carver L, Abbott R. Neurocognitive Function and Joint Attention Ability in Young Children with Autism Spectrum Disorder Versus Developmental Delay. Child Development 2002, 73: 345-358. PMID: 11949896, DOI: 10.1111/1467-8624.00411.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderJoint attention abilityAttention abilitiesPrefrontal tasksMental ageYoung childrenJoint attention taskExecutive function tasksExecutive dysfunction hypothesisCore autism symptomsVentromedial prefrontal cortexJoint attentionAttention taskFunction tasksAutism symptomsTask performanceExecutive dysfunctionSpectrum disorderPrefrontal cortexAutistic syndromeNeurocognitive functionSuch tasksTaskComparison groupAutism