2024
11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults
Matuskey D, Yang Y, Naganawa M, Koohsari S, Toyonaga T, Gravel P, Pittman B, Torres K, Pisani L, Finn C, Cramer-Benjamin S, Herman N, Rosenthal L, Franke C, Walicki B, Esterlis I, Skosnik P, Radhakrishnan R, Wolf J, Nabulsi N, Ropchan J, Huang Y, Carson R, Naples A, McPartland J. 11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults. Molecular Psychiatry 2024, 1-7. PMID: 39367053, DOI: 10.1038/s41380-024-02776-2.Peer-Reviewed Original ResearchPositron emission tomographySynaptic densityAutistic adultsBrain regionsAutistic featuresClinical phenotype of autismNon-autistic participantsPhenotype of autismNon-autistic individualsRelationship to clinical characteristicsSynaptic vesicle glycoprotein 2AAssociated with clinical measuresPost-mortem studiesPositron emission tomography scanPrefrontal cortexClinician ratingsAutism groupNeural basisBrain areasNeural processesBetween-group differencesVolumetric differencesBinding potentialDensity of synapsesAutism
2011
Recent advances in understanding the neural bases of autism spectrum disorder
McPartland JC, Coffman M, Pelphrey KA. Recent advances in understanding the neural bases of autism spectrum disorder. Current Opinion In Pediatrics 2011, 23: 628-632. PMID: 21970830, PMCID: PMC3413317, DOI: 10.1097/mop.0b013e32834cb9c9.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNeural basisBrain systemsSpectrum disorderSocial information processingSocial brain regionsBehavioral performanceInformation processingAtypical activityBrain researchIndividual-specific profilesDevelopmental contextInitial evidenceMultimethod approachBrain regionsCompensatory areasBrain functionNeural dysfunctionHeterogeneous dysfunctionBehavioral phenotypingRecent researchAnomalous functionDisordersResearchProcessing