2006
Identification of pyruvate kinase as an antigen associated with Tourette syndrome
Kansy JW, Katsovich L, McIver KS, Pick J, Zabriskie JB, Lombroso PJ, Leckman JF, Bibb JA. Identification of pyruvate kinase as an antigen associated with Tourette syndrome. Journal Of Neuroimmunology 2006, 181: 165-176. PMID: 17011640, PMCID: PMC1853370, DOI: 10.1016/j.jneuroim.2006.08.007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmino Acid SequenceAnimalsAntibodies, BacterialAntigensAutoantibodiesBrainChildCross ReactionsHumansImmunohistochemistryLongitudinal StudiesMaleMiceMice, Inbred C57BLMolecular Sequence DataProspective StudiesPyruvate KinaseRatsSeroepidemiologic StudiesStreptococcal InfectionsTicsTourette SyndromeConceptsStreptococcal infectionObsessive-compulsive disorderTourette syndromeAutoimmune targetExacerbated symptomsBeta-hemolytic streptococcal infectionEarly-onset obsessive-compulsive disorderStreptococcal M proteinPediatric populationTic disordersImmune responseSurface antigenInfectious strainsSyndromeInfectionDisordersPyruvate kinaseM proteinPatientsImmunoreactivitySymptomsAntigenAntibodiesGlycolytic enzymesM1 isoform
2003
Homez, a homeobox leucine zipper gene specific to the vertebrate lineage
Bayarsaihan D, Enkhmandakh B, Makeyev A, Greally JM, Leckman JF, Ruddle FH. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 10358-10363. PMID: 12925734, PMCID: PMC193566, DOI: 10.1073/pnas.1834010100.Peer-Reviewed Original ResearchConceptsLeucine zipper-like motifHomeobox-containing proteinLobe-finned fishesVertebrate homeobox genesFamily of genesLeucine zipper genesUnusual structural organizationZipper-like motifOverall protein structureVertebrate lineageComplementation modelZipper genePufferfish homologsHomeodomain sequencesMammalian sequencesMouse geneZHX familyMouse developmentAcidic domainHomeobox genesPhylogenetic analysisHomeodomain factorsGenomic analysisAtypical homeodomainHomez
1991
Detection of homeobox genes in development and evolution.
Murtha MT, Leckman JF, Ruddle FH. Detection of homeobox genes in development and evolution. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 10711-10715. PMID: 1720547, PMCID: PMC53000, DOI: 10.1073/pnas.88.23.10711.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBiological EvolutionCiona intestinalisCodonDipteraDrosophilaEmbryo, MammalianEmbryo, NonmammalianGenes, HomeoboxMaleMiceMolecular Sequence DataOligodeoxyribonucleotidesPolymerase Chain ReactionRestriction MappingRNASequence Homology, Nucleic AcidTelencephalonConceptsHomeobox genesHomeobox sequencesDNA-binding regulatory proteinsDiverse metazoan speciesSurvey of sequencesMouse genomic DNAImportant model systemPopulations of DNAMetazoan speciesAncient roleMetazoan evolutionPolymerase chain reactionGenomic organizationDrosophila H2.0Regulatory proteinsHlx geneGenomic DNAStudy of developmentMouse telencephalonNovel sequencesGenesOligonucleotide primersHomeodomainModel systemRNA