2011
Editorial: Developmental neuroscience comes of age
Leckman JF, March JS. Editorial: Developmental neuroscience comes of age. Journal Of Child Psychology And Psychiatry 2011, 52: 333-338. PMID: 21410471, DOI: 10.1111/j.1469-7610.2011.02378.x.Peer-Reviewed Original Research
2010
Predictors of early adulthood quality of life in children with obsessive–compulsive disorder
Palermo SD, Bloch MH, Craiglow B, Landeros-Weisenberger A, Dombrowski PA, Panza K, Smith ME, Peterson BS, Leckman JF. Predictors of early adulthood quality of life in children with obsessive–compulsive disorder. Social Psychiatry And Psychiatric Epidemiology 2010, 46: 291-297. PMID: 20191262, PMCID: PMC3645906, DOI: 10.1007/s00127-010-0194-2.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderEarly adulthoodOCD symptomsImpaired Functioning ToolMethodsA longitudinal cohort studyLongitudinal cohort studyResultsForty-two percentSeverity of OCDAverage followClinical predictorsCohort studyPoor QoLResidual impairmentMild impairmentQoLSymptomsObjectivesThe goalAnxiety symptomsAdulthoodChildrenQoL.ChildhoodHoarding symptomsImpairmentDisorders
2009
Streptococcal Upper Respiratory Tract Infections and Psychosocial Stress Predict Future Tic and Obsessive-Compulsive Symptom Severity in Children and Adolescents with Tourette Syndrome and Obsessive-Compulsive Disorder
Lin H, Williams KA, Katsovich L, Findley DB, Grantz H, Lombroso PJ, King RA, Bessen DE, Johnson D, Kaplan EL, Landeros-Weisenberger A, Zhang H, Leckman JF. Streptococcal Upper Respiratory Tract Infections and Psychosocial Stress Predict Future Tic and Obsessive-Compulsive Symptom Severity in Children and Adolescents with Tourette Syndrome and Obsessive-Compulsive Disorder. Biological Psychiatry 2009, 67: 684-691. PMID: 19833320, PMCID: PMC2843763, DOI: 10.1016/j.biopsych.2009.08.020.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-Bacterial AgentsAttention Deficit Disorder with HyperactivityChildDepressive DisorderFemaleForecastingHumansLife Change EventsMaleObsessive-Compulsive DisorderPredictive Value of TestsProspective StudiesPsychologyRespiratory Tract InfectionsSeverity of Illness IndexStreptococcal InfectionsTicsTourette SyndromeConceptsDepressive symptom severityObsessive-compulsive disorderGABHS infectionPsychosocial stressTourette syndromeSymptom severityControl subjectsStreptococcal upper respiratory tract infectionUpper respiratory tract infectionBeta-hemolytic streptococcal infectionCurrent psychosocial stressRespiratory tract infectionsHealthy control subjectsProspective longitudinal studyEarly-onset obsessive-compulsive disorderMinority of childrenOC symptom severityTract infectionsStreptococcal infectionGABHS infectionsObsessive-compulsive symptom severityClinical ratingsNew infectionsClinical ratersControl statusEditorial: Envisioning the Future after 50 Years of Science and Discovery
Charman T, Leckman J, Verhulst F. Editorial: Envisioning the Future after 50 Years of Science and Discovery. Journal Of Child Psychology And Psychiatry 2009, 50: 1-1. PMID: 19220585, DOI: 10.1111/j.1469-7610.2008.02063.x.Peer-Reviewed Original Research
1997
FUTURE THERAPIES OF TOURETTE SYNDROME * *Portions of this article have previously appeared in Chappell PB, Leckman JF, Riddle MA: The pharmacologic treatment of tic disorders. Child Adolesc Psychiatr Clin North Am. 4:197, 1995.
Chappell PB, Scahill LD, Leckman JF. FUTURE THERAPIES OF TOURETTE SYNDROME * *Portions of this article have previously appeared in Chappell PB, Leckman JF, Riddle MA: The pharmacologic treatment of tic disorders. Child Adolesc Psychiatr Clin North Am. 4:197, 1995. Neurologic Clinics 1997, 15: 429-450. PMID: 9115473, DOI: 10.1016/s0733-8619(05)70324-8.Peer-Reviewed Original ResearchConceptsTourette syndromeNew atypical antipsychotic medicationsCorticotropin-releasing factor antagonistAmino acid neurotransmitter systemsUnacceptable side effect profileAvailable pharmacologic therapiesNewer atypical antipsychoticsTreatment of ticsSide effect profileSubgroup of patientsAtypical antipsychotic medicationsTourette syndrome patientsLong-term courseReceptor affinity profileNonpharmacologic interventionsPharmacologic therapyPharmacologic treatmentAtypical antipsychoticsEffect profileAntipsychotic medicationTic disordersNeurotransmitter systemsSyndrome patientsFactor antagonistsSet of symptoms