1991
Clonidine Treatment of Gilles de la Tourette's Syndrome
Leckman JF, Hardin MT, Riddle MA, Stevenson J, Ort SI, Cohen DJ. Clonidine Treatment of Gilles de la Tourette's Syndrome. JAMA Psychiatry 1991, 48: 324-328. PMID: 2009034, DOI: 10.1001/archpsyc.1991.01810280040006.Peer-Reviewed Original ResearchConceptsGilles de la Tourette's syndromeLa Tourette's syndromeClonidine treatmentTourette syndromeTic severityDouble-blind clinical trialMotor tic severityClinical trialsClonidine hydrochlorideBehavioral symptomsClinical ratingsSyndromeMagnitude of responseClonidineTreatmentParent-rated measuresSeveritySubjectsPlaceboVideotaped interviewGroupSymptomsCliniciansHyperactivityTrials
1985
Short- and long-term treatment of Tourette's syndrome with clonidine: a clinical perspective.
Leckman J, Detlor J, Harcherik D, Ort S, Shaywitz B, Cohen D. Short- and long-term treatment of Tourette's syndrome with clonidine: a clinical perspective. Neurology 1985, 35: 343-51. PMID: 3883235, DOI: 10.1212/wnl.35.3.343.Peer-Reviewed Original ResearchConceptsTourette syndromeGilles de la Tourette's syndromePlacebo-controlled trialDouble-blind studyLong-term treatmentSerious side effectsLa Tourette's syndromeUnequivocal respondersPhonic ticsClonidineSide effectsSyndromeDrug efficacyEquivocal responseClinical perspectivePatientsEfficacyBehavior problemsSignificant improvementRespondersTrialsWeeks
1984
Tourette's Syndrome: Advances in Treatment and Research: Interoductions
COHEN D, LECKMAN J. Tourette's Syndrome: Advances in Treatment and Research: Interoductions. Journal Of The American Academy Of Child & Adolescent Psychiatry 1984, 23: 123-125. PMID: 6585413, DOI: 10.1097/00004583-198403000-00001.Peer-Reviewed Original Research
1983
Recent advances in Gilles de la Tourette syndrome: implications for clinical practice and future research.
Leckman JF, Cohen DJ. Recent advances in Gilles de la Tourette syndrome: implications for clinical practice and future research. Psychiatric Developments 1983, 1: 301-16. PMID: 6324164.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAttention Deficit Disorder with HyperactivityChildClonidineCompulsive BehaviorDopamineFemaleHaloperidolHomovanillic AcidHumansMaleObsessive BehaviorObsessive-Compulsive DisorderParasympathomimeticsPhysostigmineReceptors, AdrenergicSerotoninSex FactorsTic DisordersTourette SyndromeConceptsTourette syndromeGilles de la Tourette's syndromeDopamine receptor hypersensitivityLa Tourette's syndromeChronic multiple ticsWaning of symptomsComplex stereotypiesReceptor hypersensitivityNeurochemical disturbancesClinical presentationMetabolic findingsCSF HVAMotor involvementDopamine blockersTS patientsObsessive-compulsive behaviorClinical practiceMultiple ticsGilles deNatural historyRostrocaudal progressionFamilial aggregationSyndromeSymptomsDisorders
1982
Clonidine in the treatment of Tourette syndrome: a review of data.
Leckman JF, Cohen DJ, Detlor J, Young JG, Harcherik D, Shaywitz BA. Clonidine in the treatment of Tourette syndrome: a review of data. Advances In Neurology 1982, 35: 391-401. PMID: 6756089.Peer-Reviewed Original ResearchConceptsTS patientsLong-term symptomatic improvementPathophysiology of TSDouble-blind trialEfficacy of clonidineMinority of patientsGrowth hormone releasePrimary pathogenic importanceMinimal side effectsSymptomatic improvementBlood pressureProfile of responseNoradrenergic mechanismsMHPG levelsTherapeutic responseHormone releaseClonidinePathogenic importanceAcute dosesSide effectsTourette syndromeBehavioral symptomsPharmacologic investigationsNeurochemical systemsPatientsInteraction of biological and psychological factors in the natural history of Tourette syndrome: a paradigm for childhood neuropsychiatric disorders.
Cohen DJ, Detlor J, Shaywitz BA, Leckman JF. Interaction of biological and psychological factors in the natural history of Tourette syndrome: a paradigm for childhood neuropsychiatric disorders. Advances In Neurology 1982, 35: 31-40. PMID: 6959506.Peer-Reviewed Original Research
1981
Finding Veins
Hoder E, Leckman J, Ehrenkranz R, Kleber H, Cohen D, Poulsen J. Finding Veins. New England Journal Of Medicine 1981, 305: 1284. PMID: 7290147, DOI: 10.1056/nejm198111193052115.Peer-Reviewed Original Research