2024
Neurodevelopmental Disorders: Stereotypical Movement Disorders and Tic Disorders
Vitulano L, Vitulano M, King R, Yazgan M, Leckman J. Neurodevelopmental Disorders: Stereotypical Movement Disorders and Tic Disorders. 2024, 1685-1707. DOI: 10.1007/978-3-030-51366-5_45.Peer-Reviewed Original ResearchDevelopmental coordination disorderStereotypic movement disorderTic disordersCoordination disorderMotor skillsBest practice assessmentsNeurodevelopmental disorder groupMotor disordersMovement disordersSelf-bitingHead bangingNeurobiological disorderMotor behaviorHand flappingDisordersPractical assessmentEarly-onsetNonrhythmic movementsChildrenGroup of conditionsJerking movementsMagnetic resonance imaging techniquesSkillsIndividualsScoping Review: Digital Mental Health Interventions for Children and Adolescents Affected by War
Danese A, Martsenkovskyi D, Remberk B, Khalil M, Diggins E, Keiller E, Masood S, Awah I, Barbui C, Beer R, Calam R, Gagliato M, Jensen T, Kostova Z, Leckman J, Lewis S, Lorberg B, Myshakivska O, Pfeiffer E, Rosner R, Schleider J, Shenderovich Y, Skokauskas N, Tolan P, Caffo E, Sijbrandij M, Ougrin D, Leventhal B, Weisz J, Network T. Scoping Review: Digital Mental Health Interventions for Children and Adolescents Affected by War. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024 PMID: 38735431, DOI: 10.1016/j.jaac.2024.02.017.Peer-Reviewed Original ResearchDigital mental health interventionsMental health interventionsHealth interventionsTraditional mental health servicesComplex mental health needsMental health servicesMental health supportMental health needsRandomized controlled trialsAPA PsychInfoHealth needsHealth servicesHealth supportEvidence baseSystematic searchControlled trialsGlobal healthInterventionGoogle ScholarSelf-guidedAdolescentsYoung peopleImplementation potentialChildrenPsychINFO
2023
Cognitive training for children with ADHD: composite cognitive score outcome in a randomized controlled trial
Bikic A, Dalsgaard S, Pittman B, Leckman J, Wexler B. Cognitive training for children with ADHD: composite cognitive score outcome in a randomized controlled trial. Nordic Journal Of Psychiatry 2023, 78: 87-91. PMID: 37905332, DOI: 10.1080/08039488.2023.2270954.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderCognitive trainingDeficit/hyperactivity disorderComposite cognition scoreSessions of trainingCognitive functioningHyperactivity disorderCognitive improvementCognition scoresTraining sessionsMixed resultsFrequency of trainingTrainingChildrenSessionsIntervention groupCognitionInterventionFunctioningPost Hoc AnalysisScore outcomesControl groupPrevious studiesDisordersOutcomesNeurodevelopmental Disorders: Stereotypical Movement Disorders and Tic Disorders
Vitulano L, Vitulano M, King R, Yazgan M, Leckman J. Neurodevelopmental Disorders: Stereotypical Movement Disorders and Tic Disorders. 2023, 1-23. DOI: 10.1007/978-3-030-42825-9_45-1.Peer-Reviewed Original ResearchStereotypic movement disorderTic disordersDevelopmental coordination disorderMovement disordersMotor disordersCoordination disorderMotor skillsNeurodevelopmental disorder groupMagnetic resonance imaging techniquesBest practice assessmentHead bangingHand flappingNeurobiological disorderDisorder groupMotor behaviorDisordersNonrhythmic movementsSuch childrenPractice assessmentUnwanted attentionChildrenImaging techniquesSkillsYearsRecurrentFunctional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome
Morand-Beaulieu S, Crowley M, Grantz H, Leckman J, Sukhodolsky D. Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome. Psychological Medicine 2023, 53: 7857-7864. PMID: 37485677, PMCID: PMC10755221, DOI: 10.1017/s0033291723001940.Peer-Reviewed Original ResearchConceptsVoluntary tic suppressionTic suppressionVocal tic severityFunctional connectivityTic severityTourette syndromeRight superior frontal gyrusFirst-line treatmentBehavior therapyComprehensive Behavioral InterventionSuperior frontal gyrusRight angular gyrusVocal ticsFunctional brain networksBehavioral interventionsUsual control conditionFrontal gyrusBaselineAngular gyrusSeverityBrain networksSyndromeChildrenTherapyGyrus
2020
OCD IN CHILDREN AND ADOLESCENTS: TREATMENT OUTCOMES, FAMILY PRESENTATION, AND PREDICTORS OF TREATMENT OUTCOMES
Thomsen P, Leckman J. OCD IN CHILDREN AND ADOLESCENTS: TREATMENT OUTCOMES, FAMILY PRESENTATION, AND PREDICTORS OF TREATMENT OUTCOMES. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 59: s301-s302. DOI: 10.1016/j.jaac.2020.07.686.Peer-Reviewed Original ResearchThe prevalence of behavioral and emotional problems among Chinese school children and adolescents aged 6–16: a national survey
Cui Y, Li F, Leckman JF, Guo L, Ke X, Liu J, Zheng Y, Li Y. The prevalence of behavioral and emotional problems among Chinese school children and adolescents aged 6–16: a national survey. European Child & Adolescent Psychiatry 2020, 30: 233-241. PMID: 32172341, DOI: 10.1007/s00787-020-01507-6.Peer-Reviewed Original ResearchConceptsChild Behavior ChecklistEmotional problemsMental health providersNational surveyChinese school childrenLong-term benefitsAchenbach Child Behavior ChecklistHigh prevalenceLarge cohortPediatric psychiatristHealth providersMental disordersMultistage clusterPrevalenceCohortMental healthCBCL scoresOlder cohortBehavior ChecklistYounger cohortsChildrenEffects of the Mother-Child Education Program on Parenting Stress and Disciplinary Practices Among Refugee and Other Marginalized Communities in Lebanon: A Pilot Randomized Controlled Trial
Ponguta LA, Issa G, Aoudeh L, Maalouf C, Hein SD, Zonderman AL, Katsovich L, Khoshnood K, Bick J, Awar A, Nourallah S, Householder S, Moore CC, Salah R, Britto PR, Leckman JF. Effects of the Mother-Child Education Program on Parenting Stress and Disciplinary Practices Among Refugee and Other Marginalized Communities in Lebanon: A Pilot Randomized Controlled Trial. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 59: 727-738. PMID: 32014538, DOI: 10.1016/j.jaac.2019.12.010.Peer-Reviewed Original ResearchConceptsMother-Child Education ProgramIntervention groupWait-list control groupGroup-based interventionPost-intervention dataStress Index-Short FormModified intentionParenting Stress Index-Short FormIndex-Short FormUnderpowered analysesControl groupMother-child dyadsProgram attendanceEducation programsPilot studyEarly childhoodOutcomesTrialsHumanitarian settingsInterventionMultiple imputationMothersParenting stressChildrenChild outcomes
2019
Effects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD
Smith SD, Crowley MJ, Ferrey A, Ramsey K, Wexler BE, Leckman JF, Sukhodolsky DG. Effects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD. Psychiatry Research 2019, 278: 248-257. PMID: 31233935, PMCID: PMC6637759, DOI: 10.1016/j.psychres.2019.06.021.Peer-Reviewed Original ResearchConceptsBehavioral measuresAttentional controlIntegrated brainGo/No-Go taskGo-P3 latencySlower reaction timesSocial interventionsRobust treatment effectAttentional systemADHD groupERP measuresDifference waveP3 latencyBrain activityADHDTAU groupEEG proceduresHealthy controlsHC groupReaction timeReplication purposesERPTreatment effectsChildrenSecondary goal
2018
Adaptive treatment strategies for children and adolescents with Obsessive-Compulsive Disorder: A sequential multiple assignment randomized trial
Fatori D, de Bragança Pereira CA, Asbahr FR, Requena G, Alvarenga PG, de Mathis MA, Rohde LA, Leckman JF, March JS, Polanczyk GV, Miguel EC, Shavitt RG. Adaptive treatment strategies for children and adolescents with Obsessive-Compulsive Disorder: A sequential multiple assignment randomized trial. Journal Of Anxiety Disorders 2018, 58: 42-50. PMID: 30025255, DOI: 10.1016/j.janxdis.2018.07.002.Peer-Reviewed Original ResearchConceptsGroup cognitive behavioral therapySequential multiple assignmentTreatment failureInitial treatmentBaseline Yale-Brown ObsessiveChildhood OCDEffective initial treatmentProvision of treatmentCompulsive Scale scoresCognitive behavioral therapyAdaptive treatment strategiesYale-Brown ObsessiveSame regimenObsessive-compulsive disorderTreatment strategiesSymptom reductionPrimary analysisScale scoreFluoxetineTime pointsWeeksTreatmentChildrenEffect sizeTrialsAttention and executive functions computer training for attention-deficit/hyperactivity disorder (ADHD): results from a randomized, controlled trial
Bikic A, Leckman JF, Christensen TØ, Bilenberg N, Dalsgaard S. Attention and executive functions computer training for attention-deficit/hyperactivity disorder (ADHD): results from a randomized, controlled trial. European Child & Adolescent Psychiatry 2018, 27: 1563-1574. PMID: 29644473, DOI: 10.1007/s00787-018-1151-y.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderCognitive functionMultiple cognitive functionsComputer training programCognitive trainingHyperactivity disorderComputer trainingTraining programOutcome measuresFunctional outcome measuresIntervention groupTrainingChildrenAttentionMeasuresSecondary outcome measuresDate of registrationControl groupSignificant beneficial effectDisordersInterventionSingle-blind trialSignificant effectOutcomesTrials
2016
Rapid Eye Movement Sleep Abnormalities in Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS).
Gaughan T, Buckley A, Hommer R, Grant P, Williams K, Leckman JF, Swedo SE. Rapid Eye Movement Sleep Abnormalities in Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). Journal Of Clinical Sleep Medicine 2016, 12: 1027-32. PMID: 27166296, PMCID: PMC4918985, DOI: 10.5664/jcsm.5942.Peer-Reviewed Original ResearchConceptsPediatric acute-onset neuropsychiatric syndromeNeuropsychiatric syndromeMotor disinhibitionRapid eye movement (REM) sleep abnormalitiesPeriodic limb movementsPopulation of childrenConsecutive subjectsPediatric neurologistsFull polysomnographyHand stereotypiesPolysomnographic investigationSleep abnormalitiesSleep architectureREM sleepPolysomnographyLimb movementsSyndromeAbnormalitiesChildrenSleepDisinhibitionExcessive movementSubjectsNeurologistsA Randomized Controlled Trial of an Integrated Brain, Body, and Social Intervention for Children With ADHD
Smith SD, Vitulano LA, Katsovich L, Li S, Moore C, Li F, Grantz H, Zheng X, Eicher V, Guloksuz S, Zheng Y, Dong J, Sukhodolsky DG, Leckman JF. A Randomized Controlled Trial of an Integrated Brain, Body, and Social Intervention for Children With ADHD. Journal Of Attention Disorders 2016, 24: 780-794. PMID: 27178060, PMCID: PMC5107355, DOI: 10.1177/1087054716647490.Peer-Reviewed Original ResearchConceptsIntegrated brainComputerized cognitive remediation trainingCognitive remediation trainingSocial interventionsBehavior management strategiesRemediation trainingCognitive trainingMemory taskADHD symptomatologyADHD symptomsNeurocognitive testsTeacher ratingsBlinded clinician ratingGeneralized improvementADHDMultiple group comparisonsClinician ratingsMultiple domainsClinical functioningSignificant treatment effectOutcome measuresGroup comparisonsSecondary outcome measuresChildrenRatings
2015
Cognitive computer training in children with attention deficit hyperactivity disorder (ADHD) versus no intervention: study protocol for a randomized controlled trial
Bikic A, Leckman JF, Lindschou J, Christensen TØ, Dalsgaard S. Cognitive computer training in children with attention deficit hyperactivity disorder (ADHD) versus no intervention: study protocol for a randomized controlled trial. Trials 2015, 16: 480. PMID: 26499057, PMCID: PMC4619562, DOI: 10.1186/s13063-015-0975-8.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderDeficit hyperactivity disorderCognitive functionCognitive trainingCognitive dysfunctionHyperactivity disorderComputer trainingSymptoms of inattentionMultiple cognitive functionsCommon neurodevelopmental disorderBackgroundAttention deficit hyperactivity disorderEveryday lifeCognitive skillsADHD symptomsNeurodevelopmental disordersYoung childrenWeeks of trainingPharmacological treatmentTrainingChildrenClinical superiority trialPoor generalizationLong-term effectsControl groupIntervention groupClinical assessment and diagnostic formulation
Leckman J, Taylor E. Clinical assessment and diagnostic formulation. 2015, 403-418. DOI: 10.1002/9781118381953.ch32.Peer-Reviewed Original ResearchObsessive-compulsive symptom dimensions in a population-based, cross-sectional sample of school-aged children
Alvarenga PG, Cesar RC, Leckman JF, Moriyama TS, Torres AR, Bloch MH, Coughlin CG, Hoexter MQ, Manfro GG, Polanczyk GV, Miguel EC, do Rosario MC. Obsessive-compulsive symptom dimensions in a population-based, cross-sectional sample of school-aged children. Journal Of Psychiatric Research 2015, 62: 108-114. PMID: 25702286, DOI: 10.1016/j.jpsychires.2015.01.018.Peer-Reviewed Original ResearchConceptsSchool-aged childrenPsychiatric symptomsFamily History ScreenAdditional clinical factorsSymptom dimensionsCommunity-based sampleObsessive-compulsive symptom dimensionsClinical factorsObsessive-compulsive disorderPsychiatric comorbidityClinical impairmentSchool impairmentCross-sectional sampleAge 6Clinical samplesFamilial aggregationBiological mothersChildrenBiological relativesSymptomsPrevalenceAge distributionImpairmentNon-clinical samplePresent study
2014
Disordered Eating and Food Restrictions in Children with PANDAS/PANS
Toufexis MD, Hommer R, Gerardi DM, Grant P, Rothschild L, D'Souza P, Williams K, Leckman J, Swedo SE, Murphy TK. Disordered Eating and Food Restrictions in Children with PANDAS/PANS. Journal Of Child And Adolescent Psychopharmacology 2014, 25: 48-56. PMID: 25329522, PMCID: PMC4340640, DOI: 10.1089/cap.2014.0063.Peer-Reviewed Original ResearchConceptsPediatric acute-onset neuropsychiatric syndromeClinical presentationRestrictive food intake disorderFood intake disorderFear of chokingSymptom onsetMale predominanceNeuropsychiatric symptomsNeuropsychiatric syndromeSudden onsetFood intakeFood refusalDiagnostic criteriaFood restrictionMental disordersYounger ageBody image distortionStreptococcal bacteriaStatistical ManualSymptomsTreatment implicationsDisordersPresentationSensory issuesChildrenPediatric Acute-Onset Neuropsychiatric Syndrome
Murphy TK, Gerardi DM, Leckman JF. Pediatric Acute-Onset Neuropsychiatric Syndrome. Psychiatric Clinics Of North America 2014, 37: 353-374. PMID: 25150567, DOI: 10.1016/j.psc.2014.06.001.Peer-Reviewed Original ResearchConceptsPediatric acute-onset neuropsychiatric syndromeNeuropsychiatric syndromePediatric autoimmune neuropsychiatric disordersAutoimmune neuropsychiatric disordersAutoimmune processClinical presentationObsessive-compulsive disorderNeuropsychiatric disordersSyndromeDisordersChildrenPathophysiologySymptoms
2013
Oxytocin enhances brain function in children with autism
Gordon I, Vander Wyk B, Bennett RH, Cordeaux C, Lucas MV, Eilbott JA, Zagoory-Sharon O, Leckman JF, Feldman R, Pelphrey KA. Oxytocin enhances brain function in children with autism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 20953-20958. PMID: 24297883, PMCID: PMC3876263, DOI: 10.1073/pnas.1312857110.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSuperior temporal sulcusTemporal sulcusOrbitofrontal cortexLeft superior temporal sulcusMiddle frontal gyrusMedial prefrontal cortexRight orbitofrontal cortexSocial attunementSocial judgmentsMeaningful stimuliFrontal gyrusSpectrum disorderBrain activityPrefrontal cortexRight amygdalaSocial functioningFunctional MRIPremotor cortexHedonic evaluationBrain functionJudgmentsCortexChildrenOxytocinN-Acetylcysteine in the Treatment of Pediatric Trichotillomania: A Randomized, Double-Blind, Placebo-Controlled Add-On Trial
Bloch MH, Panza KE, Grant JE, Pittenger C, Leckman JF. N-Acetylcysteine in the Treatment of Pediatric Trichotillomania: A Randomized, Double-Blind, Placebo-Controlled Add-On Trial. Journal Of The American Academy Of Child & Adolescent Psychiatry 2013, 52: 231-240. PMID: 23452680, PMCID: PMC3745012, DOI: 10.1016/j.jaac.2012.12.020.Peer-Reviewed Original ResearchConceptsN-acetylcysteinePharmacological interventionsPediatric trichotillomaniaBenefit of NACBehavioral therapySecondary outcome measuresTreatment of childrenClinician-rated improvementMassachusetts General HospitalTreat populationPlacebo groupPrimary outcomeNAC groupGeneral HospitalOutcome measuresTreatment respondersSecondary measuresPlaceboTreatment assignmentTrichotillomaniaLinear mixed modelsTrialsSignificant differencesChildrenTherapy