2010
The Human Immune Response to Streptococcal Extracellular Antigens: Clinical, Diagnostic, and Potential Pathogenetic Implications
Johnson DR, Kurlan R, Leckman J, Kaplan EL. The Human Immune Response to Streptococcal Extracellular Antigens: Clinical, Diagnostic, and Potential Pathogenetic Implications. Clinical Infectious Diseases 2010, 50: 481-490. PMID: 20067422, DOI: 10.1086/650167.Peer-Reviewed Original ResearchConceptsAntibody titersImmune responseSingle antibody titerStreptococcal extracellular antigensB antibody titersHuman antibody responseHuman immune responsePaediatric study participantsSymptoms of infectionPotential pathogenetic implicationsThroat culturesGAS infectionAntibody responseSubsequent sequelaePathogenetic mechanismsImmunologic confirmationBlood samplesEpidemiological studiesPathogenetic implicationsStreptococcus antigensCulture resultsStudy participantsImportant human pathogenInfectionExtracellular antigens
2005
Microinfusion of antineuronal antibodies into rodent striatum: Failure to differentiate between elevated and low titers
Singer HS, Mink JW, Loiselle CR, Burke KA, Ruchkina I, Morshed S, Parveen S, Leckman JF, Hallett JJ, Lombroso PJ. Microinfusion of antineuronal antibodies into rodent striatum: Failure to differentiate between elevated and low titers. Journal Of Neuroimmunology 2005, 163: 8-14. PMID: 15885303, DOI: 10.1016/j.jneuroim.2005.02.018.Peer-Reviewed Original ResearchConceptsAntineuronal antibodiesMovement disordersMale Sprague-Dawley ratsPediatric movement disordersSerum antineuronal antibodiesSprague-Dawley ratsStart of infusionNonspecific behavioral effectsAttention deficit hyperactivity disorderDeficit hyperactivity disorderAntibody infusionSham surgeryVentrolateral striatumObsessive-compulsive disorderSerum titersAntibody titersUse of ELISAImmunohistochemical techniquesTourette syndromeBehavioral abnormalitiesRodent striatumDay 2Stereotypy scoresInfusionLow titers
2000
Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive-compulsive, and Attention-Deficit/Hyperactivity Disorders
Peterson BS, Leckman JF, Tucker D, Scahill L, Staib L, Zhang H, King R, Cohen DJ, Gore JC, Lombroso P. Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive-compulsive, and Attention-Deficit/Hyperactivity Disorders. JAMA Psychiatry 2000, 57: 364-372. PMID: 10768698, DOI: 10.1001/archpsyc.57.4.364.Peer-Reviewed Original ResearchConceptsBasal ganglia volumesAttention-deficit/hyperactivity disorderAntistreptococcal antibody titersObsessive-compulsive disorderAntibody titersGanglia volumesStreptococcal infectionAntistreptococcal antibodiesPreliminary serological evidencePrior streptococcal infectionRecurrent streptococcal infectionsHyperactivity disorderPresence of ADHDBasal ganglia nucleiHigh antibody titersGlobus pallidus nucleusDSM-IV diagnosisStreptococcal exposurePallidus nucleusAntistreptolysin OOCD comorbiditySerological evidenceSusceptible personsTic disordersDiagnostic comorbidity