Featured Publications
Imaging and optogenetic modulation of vascular mural cells in the live brain
Tong L, Hill RA, Damisah EC, Murray KN, Yuan P, Bordey A, Grutzendler J. Imaging and optogenetic modulation of vascular mural cells in the live brain. Nature Protocols 2020, 16: 472-496. PMID: 33299155, DOI: 10.1038/s41596-020-00425-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRegional cerebral blood flowMural cellsBlood-brain barrier maintenanceCerebral ischemia mouse modelAge-related neurodegenerative diseasesCerebral blood flowSmooth muscle cell physiologyBrain blood vesselsIschemia mouse modelVascular mural cellsBrain microvesselsHigh-resolution intravital imagingVascular disordersMouse modelBlood flowMuscle cell physiologyTransgenic miceCalcium transientsAlzheimer's diseaseCalcium imagingCell subtypesBarrier maintenanceNeurodegenerative diseasesTwo-photon optogeneticsBlood vessels
2019
Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas
Grutzendler J, Nedergaard M. Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas. Trends In Neurosciences 2019, 42: 528-536. PMID: 31255380, PMCID: PMC7386067, DOI: 10.1016/j.tins.2019.05.009.Peer-Reviewed Original ResearchConceptsCapillary blood flowBlood flowBrain capillary blood flowRegional cerebral blood flowCerebral blood flowRed blood cell deformabilityBlood cell deformabilityMicrovascular perfusionNeurovascular couplingMicrovascular flowBrain metabolitesMural cellsLevel-dependent changesNeural activationVessel diameterMicrovascular treeNeural activityCell deformabilityCell controlDirect visualizationMethodological standardsVasomotilityPerfusionControl