Featured Publications
ATP mediates rapid microglial response to local brain injury in vivo
Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, Littman DR, Dustin ML, Gan WB. ATP mediates rapid microglial response to local brain injury in vivo. Nature Neuroscience 2005, 8: 752-758. PMID: 15895084, DOI: 10.1038/nn1472.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsApyraseAstrocytesBrainBrain InjuriesCell CommunicationChemotaxisConnexinsGliosisGreen Fluorescent ProteinsMiceMice, TransgenicMicrogliaPhagocytosisPurinergic P2 Receptor AntagonistsReaction TimeReceptors, Purinergic P2Receptors, Purinergic P2Y1Signal TransductionConceptsRapid microglial responseMicroglial processesMicroglial responseBrain injuryG protein-coupled purinergic receptorsLocal brain injuryTraumatic brain injurySite of injuryPrincipal immune cellsPresence of apyraseParenchymal microgliaImmune cellsLocal injectionPurinergic receptorsBaseline motilityIntact brainTwo-photon imagingChannel inhibitorsMouse cortexInjuryExtracellular ATPMicrogliaEnzyme apyraseAstrocytesChemotactic response
2006
Two-photon imaging of synaptic plasticity and pathology in the living mouse brain
Grutzendler J, Gan WB. Two-photon imaging of synaptic plasticity and pathology in the living mouse brain. Neurotherapeutics 2006, 3: 489-496. PMID: 17012063, PMCID: PMC3593400, DOI: 10.1016/j.nurx.2006.07.005.Peer-Reviewed Original ResearchConceptsTwo-photon microscopyMouse brainAcute brain injuryPostsynaptic dendritic spinesAdult mouse brainCerebral ischemiaSynaptic pathologyCerebrovascular diseaseBrain injuryMouse modelDendritic spinesAnimal modelsBrain cellsIntact brainTwo-photon imagingNeuronal connectionsSynaptic plasticityAlzheimer's diseaseNeuronal structuresDiseaseBrainStructural plasticityPathologyTechnical considerationsIschemia