2023
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Young J, Park H, Kim M, Par-Young J, Bartlett H, Kim H, Unlu S, Osmani L, Shin M, Bucala R, van Dyck C, Allore H, Mecca A, You S, Kang I. Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease. Immunity & Ageing 2023, 20: 71. PMID: 38042785, PMCID: PMC10693128, DOI: 10.1186/s12979-023-00396-y.Peer-Reviewed Original ResearchPeripheral bloodT cellsAlzheimer's diseaseEM CD8Memory CD8Gene signatureAge-related immune changesIL-7 receptor alphaEffector memory CD8Strong risk factorT cell expansionAD genesAge-associated expansionImmune changesRisk factorsCD8Dementia patientsIL-7RNeuropsychological testingReceptor alphaNeurocognitive functionRT-qPCR resultsDisease severityPatientsNormal persons
2022
Effect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients
Ünlü S, Shin J, Par-Young J, Simonov M, Vinetz J, Petrylak D, Kang I, Kim J. Effect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients. Cancer Investigation 2022, 41: 77-83. PMID: 36373994, DOI: 10.1080/07357907.2022.2139839.Peer-Reviewed Original ResearchConceptsProstate cancer patientsCOVID-19 outcomesCancer patientsPoor COVID-19 outcomesAndrogen-androgen receptorExpression of TMPRSS2COVID-19 infectionSARS-CoV-2Directed therapyMean hospitalizationPCa patientsHospitalization ratesPCa casesRetrospective analysisOutcome differencesPatientsDefinitive conclusionsStatistical significanceData generate hypothesesHospitalizationTherapyTMPRSS2Cellular entryOutcomesARDT
2013
Studying the Role for CD4+ T Cell Subsets in Human Lupus
Kang I. Studying the Role for CD4+ T Cell Subsets in Human Lupus. 2013 DOI: 10.21236/ada585488.Peer-Reviewed Original ResearchIL-27IL-1Autoimmune complexesTh17 cellsLupus patientsPro-inflammatory cytokines IL-1Human monocytesExogenous IL-27IL-17 productionTh cell responsesT cell subsetsToll-like receptorsProduction of cytokinesIL-27 geneCytokines IL-1IL-1 expressionPotential therapeutic implicationsIL-10Human lupusCell subsetsPolarizing cytokinesT cellsHuman CD4Therapeutic implicationsPatients
2003
Infectious complications in SLE after immunosuppressive therapies
Kang I, Park S. Infectious complications in SLE after immunosuppressive therapies. Current Opinion In Internal Medicine 2003, 2: 629-635. DOI: 10.1097/00132980-200302060-00015.Peer-Reviewed Original ResearchSystemic lupus erythematosusMannose-binding lectin variant allelesHigh-dose glucocorticoidsImmunosuppressive therapyLupus erythematosusInfectious complicationsMycophenolate mofetilImmunosuppressive drugsRisk factorsVariant allelesMannose-binding lectin deficiencyMajor organ involvementUse of steroidsCommon viral infectionsExtrinsic risk factorsStrong risk factorIncidence of infectionHerpes zosterOrgan involvementSerious infectionsLectin deficiencyErythematosusImmune responsePatientsViral infectionInfectious complications in SLE after immunosuppressive therapies
Kang I, Park S. Infectious complications in SLE after immunosuppressive therapies. Current Opinion In Internal Medicine 2003, 2: 629-635. DOI: 10.1097/00132980-200312000-00015.Peer-Reviewed Original ResearchSystemic lupus erythematosusMannose-binding lectin variant allelesHigh-dose glucocorticoidsImmunosuppressive therapyLupus erythematosusInfectious complicationsMycophenolate mofetilImmunosuppressive drugsRisk factorsVariant allelesMannose-binding lectin deficiencyMajor organ involvementUse of steroidsCommon viral infectionsExtrinsic risk factorsStrong risk factorIncidence of infectionHerpes zosterOrgan involvementSerious infectionsLectin deficiencyErythematosusImmune responsePatientsViral infectionEnhanced proliferative response of CD4+ T cells from patients with systemic lupus erythematosus by T-cell receptor stimulation
Park S, Kang I, Kim H, Craft J. Enhanced proliferative response of CD4+ T cells from patients with systemic lupus erythematosus by T-cell receptor stimulation. Arthritis Research & Therapy 2003, 5: 151. PMCID: PMC2833942, DOI: 10.1186/ar952.Peer-Reviewed Original Research
2000
Anserine Bursitis in Patients With Osteoarthritis of the Knee
KANG I, HAN S. Anserine Bursitis in Patients With Osteoarthritis of the Knee. Southern Medical Journal 2000, 93: 207-209. PMID: 10701790, DOI: 10.1097/00007611-200002000-00011.Peer-Reviewed Original ResearchAnserine Bursitis in Patients With Osteoarthritis of the Knee
KANG I, HAN S. Anserine Bursitis in Patients With Osteoarthritis of the Knee. Southern Medical Journal 2000, 93: 207-209. DOI: 10.1097/00007611-200093020-00011.Peer-Reviewed Original Research
1997
Central Nervous System Vasculitis in Systemic Lupus Erythematosus
Kang I, Hutchinson G. Central Nervous System Vasculitis in Systemic Lupus Erythematosus. JCR Journal Of Clinical Rheumatology 1997, 3: 349-352. PMID: 19078225, DOI: 10.1097/00124743-199712000-00010.Peer-Reviewed Original ResearchSystemic lupus erythematosusCentral nervous systemOral cyclophosphamideCNS vasculitisCNS symptomsLupus erythematosusBrain biopsyCentral nervous system vasculitisActive systemic lupus erythematosusDaily oral cyclophosphamideHigh-dose prednisoneIntravenous pulse methylprednisolonePulse methylprednisoloneSLE patientsEarly institutionVasculitisNervous systemShort courseErythematosusMethylprednisolonePrednisoneCyclophosphamideBiopsyPatientsSymptoms