1998
Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats
Jacobs H, Bogue C, Pinter E, Wilson C, Warshaw J, Gross I. Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats. Pediatric Research 1998, 44: 99-104. PMID: 9667378, DOI: 10.1203/00006450-199807000-00016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsButyratesButyric AcidDiabetes Mellitus, ExperimentalEmbryonic and Fetal DevelopmentFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxGestational AgeHistone Deacetylase InhibitorsLungOrgan Culture TechniquesPregnancyPregnancy in DiabeticsRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticConceptsLung developmentLung explantsSurfactant apoproteinExperimental animalsLung mRNA levelsElevated levelsEffect of diabetesFetal rat lung explantsLungs of fetusesRat lung explantsEffect of butyrateAntenatal exposureMaternal diabetesMetabolic abnormalitiesStreptozotocin treatmentLower incidenceNormal ratsDiabetesDexamethasoneLevel of expressionRatsTreatment of explantsSodium butyrateMRNA levelsAlters expression
1996
Retinoic acid increases surfactant protein mRNA in fetal rat lung in culture
Bogue CW, Jacobs HC, Dynia DW, Wilson CM, Gross I. Retinoic acid increases surfactant protein mRNA in fetal rat lung in culture. American Journal Of Physiology 1996, 271: l862-l868. PMID: 8944731, DOI: 10.1152/ajplung.1996.271.5.l862.Peer-Reviewed Original Research
1992
Surfactant protein C: hormonal control of SP-C mRNA levels in vitro
Veletza S, Nichols K, Gross I, Lu H, Dynia D, Floros J. Surfactant protein C: hormonal control of SP-C mRNA levels in vitro. American Journal Of Physiology 1992, 262: l684-l687. PMID: 1319687, DOI: 10.1152/ajplung.1992.262.6.l684.Peer-Reviewed Original ResearchMeSH Keywords8-Bromo Cyclic Adenosine MonophosphateAnalysis of VarianceAnimalsBase SequenceBucladesineCell NucleusCloning, MolecularDexamethasoneFetusGene LibraryHumansKineticsLungMolecular Sequence DataOligonucleotide ProbesOrgan Culture TechniquesProteolipidsPulmonary SurfactantsRatsRNA, MessengerTranscription, GeneticConceptsSP-C mRNA levelsSP-C mRNAMRNA levelsHormonal regulationSurfactant protein CSurfactant protein mRNAsTranscriptional assaysThyroid hormone T3Transcriptional stepNorthern blotCDNA probeProtein mRNACyclic monophosphateCAMP analogSpHormone T3Hormonal controlMRNASurfactant proteinsRegulationLung explantsDose-dependent increaseRat lung explantsExplantsProtein C
1990
Regulation of surfactant protein A mRNA by hormones and butyrate in cultured fetal rat lung
Nichols K, Floros J, Dynia D, Veletza S, Wilson C, Gross I. Regulation of surfactant protein A mRNA by hormones and butyrate in cultured fetal rat lung. American Journal Of Physiology 1990, 259: l488-l495. PMID: 2175559, DOI: 10.1152/ajplung.1990.259.6.l488.Peer-Reviewed Original Research8-Bromo Cyclic Adenosine MonophosphateAnimalsBucladesineButyratesButyric AcidDexamethasoneFetusGene Expression RegulationGlycoproteinsLungOrgan Culture TechniquesPhospholipidsProteolipidsPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated ProteinsPulmonary SurfactantsRatsRNA ProbesRNA, MessengerTriiodothyronine
1986
Glucocorticoid stimulation of choline-phosphate cytidylyltransferase activity in fetal rat lung: Receptor-response relationships
Rooney S, Dynia D, Smart D, Chu A, Ingleson L, Wilson C, Gross I. Glucocorticoid stimulation of choline-phosphate cytidylyltransferase activity in fetal rat lung: Receptor-response relationships. Biochimica Et Biophysica Acta 1986, 888: 208-216. PMID: 3017448, DOI: 10.1016/0167-4889(86)90023-6.Peer-Reviewed Original ResearchConceptsEffect of dexamethasoneDexamethasone bindingCholine-phosphate cytidylyltransferase activitySpecific dexamethasone bindingFetal lung maturationFetal rat lung explantsCholine-phosphate cytidylyltransferaseSpecific nuclear bindingCytidylyltransferase activityRat lung explantsReceptor-mediated processSupernatant fractionFetal rat lungDose-response curveDexamethasone-treated culturesLung maturationGlucocorticoid bindingGlucocorticoid actionDe novo phosphatidylcholine synthesisLung explantsRat lungDexamethasoneGlucocorticoid stimulationStimulatory effectCholine incorporation
1984
Corticosteroid binding by fetal rat and rabbit lung in organ culture
Ballard P, Ballard R, Gonzales L, Huemmelink R, Wilson C, Gross I. Corticosteroid binding by fetal rat and rabbit lung in organ culture. The Journal Of Steroid Biochemistry And Molecular Biology 1984, 21: 117-126. PMID: 6482426, DOI: 10.1016/0022-4731(84)90371-6.Peer-Reviewed Original ResearchConceptsRabbit lungsFetal ratsDexamethasone binding capacityConcentrations of dexamethasoneFetal lung cellsHalf-maximal stimulationGlucocorticoid effectsPhosphatidylcholine synthesisActive glucocorticoidsCorticosteroid metabolismDexamethasone bindingGlucocorticoid actionReceptor concentrationRabbit fetusesReceptor capacityFetal developmentRat lungLungBinding capacityFemale rabbitsLung cellsDexamethasoneCholine incorporationPhysiologic activityPrior exposure
1983
Fetal rat lung maturation: initiation and modulation
Gross I, Wilson C. Fetal rat lung maturation: initiation and modulation. Journal Of Applied Physiology 1983, 55: 1725-1732. PMID: 6662763, DOI: 10.1152/jappl.1983.55.6.1725.Peer-Reviewed Original ResearchConceptsFetal lung maturationGestational ageLung maturationCholine incorporationEquivalent gestational ageFetal rat lungGlucocorticoid bindingDays gestationLung tissueFetal lungRat lungBiochemical markersLung developmentMorphological maturationDSPC contentMesenchymal tissueMaturational processesMarked increaseHormoneSimilar increaseLungLate modulationPhosphatidylcholine synthesisAgeMaturationCorticosteroid Stimulation of Phosphatidylcholine Synthesis in Cultured Fetal Rabbit Lung: Evidence for de Novo Protein Synthesis Mediated by Glucocorticoid Receptors*
GROSS I, BALLARD P, BALLARD R, JONES C, WILSON C. Corticosteroid Stimulation of Phosphatidylcholine Synthesis in Cultured Fetal Rabbit Lung: Evidence for de Novo Protein Synthesis Mediated by Glucocorticoid Receptors*. Endocrinology 1983, 112: 829-837. PMID: 6822213, DOI: 10.1210/endo-112-3-829.Peer-Reviewed Original Research
1982
Fetal lung in organ culture. IV. Supra-additive hormone interactions
Gross I, Wilson C. Fetal lung in organ culture. IV. Supra-additive hormone interactions. Journal Of Applied Physiology 1982, 52: 1420-1425. PMID: 6286561, DOI: 10.1152/jappl.1982.52.6.1420.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBucladesineCaffeineCholineDexamethasoneDrug SynergismHormonesLungOrgan Culture TechniquesPhosphatidylcholinesRatsTheophyllineTriiodothyronineConceptsFetal lung maturationLung maturationSupra-additive interactionOrgan cultureCombination of dexamethasoneRate of incorporationFetal rat lungVivo animal studiesHormone administrationFetal lungAnimal studiesRat lungSupra-additive stimulationThyroid hormonesNM dexamethasoneDexamethasone concentrationsMaximal stimulationLungDexamethasoneNM triiodothyroninePulmonary surfactantSignificant increaseStimulationPrecursor incorporationCyclic monophosphate
1981
Organotypic Culture of Fetal Rat Lung: Evaluation and Comparison with Organ Culture1–3
Gross I, Freedman R, Wilson C, Lindsey S. Organotypic Culture of Fetal Rat Lung: Evaluation and Comparison with Organ Culture1–3. American Journal Of Respiratory And Critical Care Medicine 1981, 123: 313-9. PMID: 7224342, DOI: 10.1164/arrd.1981.123.3.313.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAnimalsCholineCulture TechniquesFetusLungOrgan Culture TechniquesPhosphatidylcholinesPhospholipidsPulmonary AlveoliRats
1980
Insulin antagonism of dexamethasone-induced stimulation of cholinephosphate cytidylyltransferase in fetal rat lung in organ culture
Rooney S, Ingleson L, Wilson C, Gross I. Insulin antagonism of dexamethasone-induced stimulation of cholinephosphate cytidylyltransferase in fetal rat lung in organ culture. Lung 1980, 158: 151-155. PMID: 6255261, DOI: 10.1007/bf02713717.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCholine-Phosphate CytidylyltransferaseCytidine Diphosphate CholineDexamethasoneFetusInsulinLungNucleotidyltransferasesOrgan Culture TechniquesRats
1979
Influence of Aminophylline and Cyclic AMP on Glycogen Metabolism in Fetal Rat Lung in Organ Culture
Maniscalco W, Wilson C, Gross I. Influence of Aminophylline and Cyclic AMP on Glycogen Metabolism in Fetal Rat Lung in Organ Culture. Pediatric Research 1979, 13: 1319-1322. PMID: 230447, DOI: 10.1203/00006450-197912000-00003.Peer-Reviewed Original ResearchConceptsFetal rat lungRat lungCyclic AMPFetal pulmonary surfactantInfluence of aminophyllineEffect of aminophyllineGlycogen synthase I activityOrgan cultureLung phospholipid synthesisGlycogen metabolismTotal phosphorylase activityDibutyryl cyclic AMPMonophosphate phosphodiesterase inhibitorSynthase I activityPhospholipid synthesisAminophyllinePhosphodiesterase inhibitorGlycogen contentLungGlycogen breakdownCyclic AMP treatmentAMP treatmentPulmonary surfactantAMPPhosphorylase activityThe influence of hormones on the biochemical development of fetal rat lung in organ culture I. Estrogen
Gross I, Wilson C, Ingleson L, Brehier A, Rooney S. The influence of hormones on the biochemical development of fetal rat lung in organ culture I. Estrogen. Biochimica Et Biophysica Acta 1979, 575: 375-383. PMID: 518894, DOI: 10.1016/0005-2760(79)90106-1.Peer-Reviewed Original ResearchConceptsFetal rat lungPercentage of radioactivityEstrogen actsFetal lungRat lungPhospholipid fractionInfluence of hormonesProtein/DNA ratioEstrogen treatmentIncorporation of cholineLungGlycogen contentTotal phospholipidsOrgan cultureSignificant stimulationPulmonary surfactantBiochemical developmentIndividual phospholipidsPhosphatidylcholine synthesisSignificant changesPhospholipid synthesisPhospholipidsAbundant phospholipidDNA ratioRadioactivity
1978
An organ culture model for study of biochemical development of fetal rat lung
Gross I, Smith G, Maniscalco W, Czajka M, Wilson C, Rooney S. An organ culture model for study of biochemical development of fetal rat lung. Journal Of Applied Physiology 1978, 45: 355-362. PMID: 212389, DOI: 10.1152/jappl.1978.45.3.355.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarbon DioxideCholineCyclic AMPGlucoseLungModels, BiologicalOrgan Culture TechniquesPhosphatidylcholinesRats
1977
Aminophylline stimulates the incorporation of choline into phospholipid in explants of fetal rat lung in organ culture
Gross I, Rooney S. Aminophylline stimulates the incorporation of choline into phospholipid in explants of fetal rat lung in organ culture. Biochimica Et Biophysica Acta 1977, 488: 263-269. PMID: 196659, DOI: 10.1016/0005-2760(77)90183-7.Peer-Reviewed Original ResearchMeSH KeywordsAminophyllineAnimalsBucladesineCholineCholine KinaseDiacylglycerol CholinephosphotransferaseFemaleFetusGestational AgeLungOrgan Culture TechniquesPhospholipidsPregnancyRatsConceptsFetal rat lungRat lungCholine incorporationIncorporation of cholineCyclic AMPCyclic AMP phosphodiesterase inhibitorDirect stimulatory effectOrgan cultureF12 mediumAminophylline treatmentDibutyryl cyclic AMPMM aminophyllinePhosphodiesterase inhibitorAminophyllineLungStimulatory effectSimilar changesAMPStimulationDirect effectSmall increaseCholine kinaseCholineExposurePhospholipids