2004
Three distinct mechanisms of HCO3− secretion in rat distal colon
Vidyasagar S, Rajendran VM, Binder HJ. Three distinct mechanisms of HCO3− secretion in rat distal colon. American Journal Of Physiology - Cell Physiology 2004, 287: c612-c621. PMID: 15308466, DOI: 10.1152/ajpcell.00474.2003.Peer-Reviewed Original ResearchConceptsRat distal colonShort-chain fatty acidsColonic mucosaDistal colonRat distal colonic mucosaDistal colonic mucosaCl- channel blockerSCFA/Channel blockersSerosal layerCrypt cellsCFTR blockerMicroM DIDSApical membrane anion channelApical membraneSecretionDependent secretionColonLumen ClSecretory mechanismMammalian colonBlockersMucosaStat techniqueDIDS
2003
Apical NHE isoforms differentially regulate butyrate-stimulated Na absorption in rat distal colon
Krishnan S, Rajendran VM, Binder HJ. Apical NHE isoforms differentially regulate butyrate-stimulated Na absorption in rat distal colon. American Journal Of Physiology - Cell Physiology 2003, 285: c1246-c1254. PMID: 12878493, DOI: 10.1152/ajpcell.00598.2002.Peer-Reviewed Original Research
1999
Stimulation of Sodium Chloride Absorption from Secreting Rat Colon by Short-Chain Fatty Acids
Krishnan S, Ramakrishna BS, Binder H. Stimulation of Sodium Chloride Absorption from Secreting Rat Colon by Short-Chain Fatty Acids. Digestive Diseases And Sciences 1999, 44: 1924-1930. PMID: 10505736, DOI: 10.1023/a:1018871412748.Peer-Reviewed Original ResearchConceptsShort-chain fatty acidsNa absorptionNaCl absorptionControl normal mucosaNet Cl secretionRat distal colonSodium chloride absorptionPresence of SCFAEffect of butyrateElectroneutral NaCl absorptionVoltage-clamp conditionsFatty acidsDistal colonNormal mucosaRat colonAbsorptive pathwaysCl(-) secretionChloride absorptionColonCAMP elevationSCFAMucosaSecretagoguesAdenosine monophosphateSecretion
1991
Apical membrane localization of ouabain-sensitive K(+)-activated ATPase activities in rat distal colon
Del Castillo J, Rajendran V, Binder H. Apical membrane localization of ouabain-sensitive K(+)-activated ATPase activities in rat distal colon. American Journal Of Physiology 1991, 261: g1005-g1011. PMID: 1837421, DOI: 10.1152/ajpgi.1991.261.6.g1005.Peer-Reviewed Original ResearchConceptsRat distal colonOuabain-insensitive fractionDistal colonOuabain-sensitive fractionOuabain-insensitive componentHalf-maximal concentrationApical membraneATPase activityColonic mucosaProximal colonColonActivation curveAbsorptive processesAdenosinetriphosphatase activityApical membrane localizationBasolateral membraneHomogenatesN-ethylmaleimideMucosaActivityOmeprazole
1990
Active potassium absorption in rat distal colon.
Sweiry J, Binder H. Active potassium absorption in rat distal colon. The Journal Of Physiology 1990, 423: 155-170. PMID: 2143781, PMCID: PMC1189751, DOI: 10.1113/jphysiol.1990.sp018016.Peer-Reviewed Original ResearchConceptsNa-depleted animalsRat distal colonActive potassium absorptionDistal colonNormal colonFree Ringer solutionGroups of animalsResult of inhibitionColonMucosal ouabainPotassium absorptionRinger's solutionSerosal solutionSerosalAnimalsApical membraneSaturable fluxMucosaAffinity constantsOmeprazoleATPaseSecretion
1989
Characterization of aldosterone-induced potassium secretion in rat distal colon.
Sweiry J, Binder H. Characterization of aldosterone-induced potassium secretion in rat distal colon. Journal Of Clinical Investigation 1989, 83: 844-851. PMID: 2921323, PMCID: PMC303757, DOI: 10.1172/jci113967.Peer-Reviewed Original Research
1987
Mechanism of electroneutral sodium chloride absorption in distal colon of the rat
Binder H, Foster E, Budinger M, Hayslett J. Mechanism of electroneutral sodium chloride absorption in distal colon of the rat. Gastroenterology 1987, 93: 449-455. PMID: 3609655, DOI: 10.1016/0016-5085(87)90905-x.Peer-Reviewed Original ResearchConceptsSodium chloride absorptionElectroneutral sodium chloride absorptionNet sodium absorptionNet chloride absorptionDistal colonChloride absorptionSodium absorptionRat distal colonSodium chloride cotransportVoltage-clamp conditionsMM furosemideMM amilorideMucosal bathing solutionChloride transportClamp conditionsColonBathing solutionRatsElectrogenic sodiumMechanism of sodiumAmilorideSodiumAbsence of potassiumCotransportMucosa
1986
Dietary potassium modulates active potassium absorption and secretion in rat distal colon
Foster E, Sandle G, Hayslett J, Binder H. Dietary potassium modulates active potassium absorption and secretion in rat distal colon. American Journal Of Physiology 1986, 251: g619-g626. PMID: 3022598, DOI: 10.1152/ajpgi.1986.251.5.g619.Peer-Reviewed Original ResearchConceptsNet potassium absorptionNet potassium secretionPotassium secretionDistal colonic mucosaPotassium-loaded ratsRat distal colonPotassium transportActive potassium absorptionDietary potassiumPotassium absorptionColonic mucosaDistal colonMucosal amilorideLarge intestinePotassium depletionBody storesActive potassium transportSecretionBathing solutionPotassium loadingGroupK fluxesMucosaColonControl
1975
Effect of Shigella Enterotoxin on Electrolyte Transport in Rabbit Ileum
Donowitz M, Keusch G, Binder H. Effect of Shigella Enterotoxin on Electrolyte Transport in Rabbit Ileum. Gastroenterology 1975, 69: 1230-1237. PMID: 172398, DOI: 10.1016/s0016-5085(19)32315-7.Peer-Reviewed Original ResearchConceptsCyclic adenosine monophosphate levelsRabbit ileal mucosaIntestinal secretionShigella enterotoxinAdenosine monophosphate levelsElectrolyte secretionControl mucosaIleal mucosaCholera enterotoxinMonophosphate levelsNet sodium absorptionNet sodium secretionIntracellular cyclic adenosine monophosphate (cAMP) levelsAdenosine monophosphateEscherichia coli enterotoxinIntestinal waterUssing chambersRabbit ileumCyclic adenosine monophosphateSodium secretionMucosaSmall intestineSodium absorptionControl tissuesElectrolyte accumulation
1968
Acute Irradiation Proctitisi in Man Development of eosinophilic crypt abscesses
Gelfand M, Tepper M, Katz L, Binder H, Yesner R, Floch M. Acute Irradiation Proctitisi in Man Development of eosinophilic crypt abscesses. Gastroenterology 1968, 54: 401-411. PMID: 5643028, DOI: 10.1016/s0016-5085(68)80101-5.Peer-Reviewed Original ResearchConceptsCrypt abscessesTissue eosinophiliaMarked tissue eosinophiliaMucoid rectal dischargeProminent tissue eosinophiliaLoss of vascularityPelvic irradiationRectal dischargeAbnormal mucosaRectal mucosaLeukocytic infiltrationMalignant diseaseBiopsy specimensHistological abnormalitiesInjurious stimuliCrypt epitheliumLamina propriaRadiation therapyX-ray treatmentAbscessLuminal patternMucosaTherapyNicotinamide adenine dinucleotideHistochemical studies