2024
The extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries
Dorr D, Markwardt S, Bobo M, Allore H, Botoseneanu A, Newsom J, Nagel C, Quiñones A. The extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries. BMC Geriatrics 2024, 24: 777. PMID: 39304796, PMCID: PMC11414248, DOI: 10.1186/s12877-024-05329-y.Peer-Reviewed Original ResearchConceptsHigh multimorbidityMultimorbidity levelOlder adultsHigher levels of multimorbidityHealth and Retirement Study dataAssociated with sociodemographic characteristicsWell-being of older adultsLevels of multimorbidityProgression of multimorbidityImpact of multimorbidityBurden of multimorbidityHigher healthcare utilizationRetirement Study dataYounger birth cohortsMultimorbidity groupsHealthcare utilizationLower educationNon-HispanicMultimorbiditySociodemographic characteristicsMedicare beneficiariesSocioeconomic statusHealth indicatorsBirth cohortChronic diseasesMultimorbidity and associated informal care receiving characteristics for US older adults: a latent class analysis
Liu R, Nagel C, Chen S, Newsom J, Allore H, Quiñones A. Multimorbidity and associated informal care receiving characteristics for US older adults: a latent class analysis. BMC Geriatrics 2024, 24: 571. PMID: 38956501, PMCID: PMC11221032, DOI: 10.1186/s12877-024-05158-z.Peer-Reviewed Original ResearchConceptsNational Health and Aging Trends StudyMultimorbidity patternsCare needsOlder adultsSelf-careInformal careLatent class analysisCare receiver characteristicsCombinations of multimorbidityPerson-centered carePatterns of multimorbidityDifferential care needsUS older adultsAssociated with lower oddsAssociated with higher oddsGroup of older adultsMultinomial logistic regression modelModerate cognitive impairmentClass analysisLogistic regression modelsInformal caregiversBackgroundOlder adultsCare recipientsMultimorbidity groupsChronic conditions
2022
Depressive Multimorbidity and Trajectories of Functional Status among Older Americans: Differences by Racial/Ethnic Group
Botoseneanu A, Elman M, Allore H, Dorr D, Newsom J, Nagel C, Quiñones A. Depressive Multimorbidity and Trajectories of Functional Status among Older Americans: Differences by Racial/Ethnic Group. Journal Of The American Medical Directors Association 2022, 24: 250-257.e3. PMID: 36535384, PMCID: PMC10280885, DOI: 10.1016/j.jamda.2022.11.015.Peer-Reviewed Original ResearchConceptsFunctional limitationsOlder adultsSomatic multimorbidityBody mass indexScreening/treatmentDaily living limitationsUS older adultsNon-Hispanic blacksHigher depressive symptomsAdults age 65Race/ethnicityMass indexTreatment optionsBaseline ageFunctional statusRepresentative sampleHigh prevalenceInstrumental activitiesFunctional declineDaily livingMultimorbidityDepressive symptomsSomatic diseasesDepressive symptomatologyEthnic groupsThe Contribution of Chronic Conditions to Hospitalization, Skilled Nursing Facility Admission, and Death: Variation by Race
Quiñones AR, McAvay GJ, Peak KD, Vander Wyk B, Allore HG. The Contribution of Chronic Conditions to Hospitalization, Skilled Nursing Facility Admission, and Death: Variation by Race. American Journal Of Epidemiology 2022, 191: 2014-2025. PMID: 35932162, PMCID: PMC10144669, DOI: 10.1093/aje/kwac143.Peer-Reviewed Original ResearchMeSH KeywordsAgedChronic DiseaseEthnicityHospitalizationHumansMedicareSkilled Nursing FacilitiesUnited StatesConceptsSkilled nursing facility admissionsNursing facility admissionsChronic conditionsFacility admissionMedicare beneficiariesCostly health care utilizationHealth care utilizationRacial differencesNon-Hispanic blacksWhite Medicare beneficiariesAverage attributable fractionHealth-related outcomesImportant health-related outcomesNon-Hispanic White older adultsWhite older adultsAging Trends StudyMultimorbidity burdenRenal morbidityOngoing careAttributable fractionNational HealthCardiovascular conditionsOlder adultsImportant markerHospitalizationRisk Factors of Skilled Nursing Facility Admissions and the Interrelation With Hospitalization and Amount of Informal Caregiving Received
Cao Y, Allore H, Gutman R, Vander Wyk B, Jørgensen TSH. Risk Factors of Skilled Nursing Facility Admissions and the Interrelation With Hospitalization and Amount of Informal Caregiving Received. Medical Care 2022, 60: 294-301. PMID: 35149662, PMCID: PMC8916995, DOI: 10.1097/mlr.0000000000001697.Peer-Reviewed Original ResearchConceptsSkilled nursing facility admissionsNursing facility admissionsNumber of hospitalizationsSNF admissionImportant risk factorRisk factorsHospital admissionFacility admissionNon-Hispanic white race/ethnicityWhite race/ethnicityInformal caregivingWeak positive correlationDaily living (ADL) disabilityPossible risk factorsPositive correlationAging Trends StudyRace/ethnicityObservational followStrong positive correlationNational HealthAdmissionDementia diagnosisHospitalizationAlzheimer's diseaseHealth factors
2020
Individual Heterogeneity in the Probability of Hospitalization, Skilled Nursing Facility Admission, and Mortality
McAvay GJ, Vander Wyk B, Allore H. Individual Heterogeneity in the Probability of Hospitalization, Skilled Nursing Facility Admission, and Mortality. The Journals Of Gerontology Series A 2020, 76: 1668-1677. PMID: 33320184, PMCID: PMC8361334, DOI: 10.1093/gerona/glaa314.Peer-Reviewed Original ResearchConceptsSkilled nursing facility admissionsNursing facility admissionsChronic kidney diseaseHeart failureFacility admissionKidney diseaseChronic conditionsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseIschemic heart diseaseHealth care utilizationProbability of hospitalizationPulmonary diseaseCare utilizationMortality outcomesPoor outcomeHeart diseaseNational HealthOdds ratioDisease combinationsLongitudinal cohortSociodemographic factorsMedicaid ServicesDiseaseAging Study
2016
Methodology to Estimate the Longitudinal Average Attributable Fraction of Guideline-recommended Medications for Death in Older Adults With Multiple Chronic Conditions
Allore HG, Zhan Y, Cohen AB, Tinetti ME, Trentalange M, McAvay G. Methodology to Estimate the Longitudinal Average Attributable Fraction of Guideline-recommended Medications for Death in Older Adults With Multiple Chronic Conditions. The Journals Of Gerontology Series A 2016, 71: 1113-1116. PMID: 26748093, PMCID: PMC4945884, DOI: 10.1093/gerona/glv223.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAged, 80 and overCardiovascular DiseasesDrug PrescriptionsDrug Therapy, CombinationFemaleFollow-Up StudiesHumansMaleMedicareMultiple Chronic ConditionsPractice Guidelines as TopicRetrospective StudiesSurveys and QuestionnairesSurvival RateThiazidesTreatment OutcomeUnited StatesConceptsMultiple chronic conditionsAverage attributable fractionChronic conditionsAttributable fractionCardiovascular conditionsHeart failureMedicare Current Beneficiary Survey participantsRenin-angiotensin system blockersGuideline-recommended medicationsMore chronic conditionsAge-stratified modelsSystem blockersBeta blockersCardiovascular medicationsOral medicationsAtrial fibrillationMedication effectsMedicationsAge strataParticipant characteristicsOlder adultsSurvivalThiazidesBlockersAge
2015
Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study
Tinetti ME, McAvay G, Trentalange M, Cohen AB, Allore HG. Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study. The BMJ 2015, 351: h4984. PMID: 26432468, PMCID: PMC4591503, DOI: 10.1136/bmj.h4984.Peer-Reviewed Original ResearchConceptsSerotonin-norepinephrine reuptake inhibitorsMultiple chronic conditionsSelective serotonin reuptake inhibitorsAdjusted hazard ratioRisk of deathCalcium channel blockersChronic conditionsHazard ratioΒ-blockersCohort studyReuptake inhibitorsAtrial fibrillationOlder adultsChannel blockersCardiovascular drugsSSRIs/serotonin-norepinephrine reuptake inhibitorsRenin-angiotensin system blockersNorepinephrine reuptake inhibitorsSerotonin reuptake inhibitorsCommon combinationRAS blockersSystem blockersStudy drugHeart failureThromboembolic diseaseComparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia
Barakat LA, Juthani-Mehta M, Allore H, Trentalange M, Tate J, Rimland D, Pisani M, Akgün KM, Goetz MB, Butt AA, Rodriguez-Barradas M, Duggal M, Crothers K, Justice AC, Quagliarello VJ. Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia. HIV Medicine 2015, 16: 421-430. PMID: 25959543, PMCID: PMC5015437, DOI: 10.1111/hiv.12244.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaVeterans Aging Cohort StudyVACS IndexCAP outcomesAntiretroviral therapyOlder adultsHigher VACS indexDays of dischargeAging Cohort StudyUninfected participantsCohort studyMean LOSHIV infectionLonger LOSClinical outcomesUnadjusted analysesUninfected groupMultivariable modelEligibility criteriaHIVMale veteransMortality rateART useMortalityOutcomes
2014
Socioeconomic Stratification and Multidimensional Health Trajectories: Evidence of Convergence in Later Old Age
Xu X, Liang J, Bennett JM, Botoseneanu A, Allore HG. Socioeconomic Stratification and Multidimensional Health Trajectories: Evidence of Convergence in Later Old Age. The Journals Of Gerontology Series B 2014, 70: 661-671. PMID: 25161216, PMCID: PMC4462671, DOI: 10.1093/geronb/gbu095.Peer-Reviewed Original ResearchConceptsNet worth