Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, Kranzler H, Gelernter J, Harris K, Tucker-Drob E, Waldman I, Palmer A, Harden K, Koellinger P, Dick D. Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Nature Neuroscience 2021, 24: 1367-1376. PMID: 34446935, PMCID: PMC8484054, DOI: 10.1038/s41593-021-00908-3.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityBehavior, AddictiveBehavioral SymptomsComputational BiologyCrimeGenetic Association StudiesGenome-Wide Association StudyHIV InfectionsHumansMeta-Analysis as TopicMultifactorial InheritanceMultivariate AnalysisOpioid-Related DisordersReproducibility of ResultsSelf-ControlSuicideUnemploymentConceptsGenome-wide association analysisGenome-wide analysisNervous system developmentSingle-trait analysisGenetic lociAssociation analysisPolygenic scoresGenetic correlationsTraitsGenetic association