2023
Medications for alcohol use disorder improve survival in patients with hazardous drinking and alcohol-associated cirrhosis
Rabiee A, Mahmud N, Falker C, Garcia-Tsao G, Taddei T, Kaplan D. Medications for alcohol use disorder improve survival in patients with hazardous drinking and alcohol-associated cirrhosis. Hepatology Communications 2023, 7: e0093. PMID: 36972386, PMCID: PMC10043587, DOI: 10.1097/hc9.0000000000000093.Peer-Reviewed Original ResearchMeSH KeywordsAcamprosateAlcohol DeterrentsAlcoholismHumansLiver CirrhosisLiver Cirrhosis, AlcoholicNaltrexoneRetrospective StudiesConceptsAlcohol-associated cirrhosisAlcohol use disorderUse disordersCause mortalityImproved survivalPropensity scoreInpatient diagnosis codesRetrospective cohort studyCox regression analysisActive alcohol useCirrhosis decompensationCohort studyConcurrent diagnosisLiver diseasePotential confoundersDiagnosis codesVeteran outcomesCirrhosis diagnosisStrong negative predictorCirrhosisPatientsHazardous drinkingAlcohol use behaviorsCosts AssociatedAlcohol use
1991
Propranolol in the prevention of the first hemorrhage from esophagogastric varices: A multicenter, randomized clinical trial
Conn H, Grace N, Bosch J, Groszmann R, Rodés J, Wright S, Matloff D, Garcia‐Tsao G, Fisher R, Navasa M, Drewniak S, Atterbury C, Bordas J, Lerner E, Bramante C. Propranolol in the prevention of the first hemorrhage from esophagogastric varices: A multicenter, randomized clinical trial. Hepatology 1991, 13: 902-912. PMID: 2029994, DOI: 10.1002/hep.1840130517.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientVenous pressure gradientPlacebo groupPropranolol groupEsophageal varicesVariceal hemorrhageChild class AEffectiveness of propranololFirst variceal hemorrhageInitial variceal hemorrhageCessation of therapyPortal hypertensive gastropathyChild class BDoses of propranololLarge esophageal varicesHepatic vein cathetersBeats/minClass BPlacebo patientsPropranolol patientsAlcoholic cirrhosisHypertensive gastropathyMean followMedian doseLarge varices
1989
Long‐term hemodynamic effects of ketanserin, a 5‐hydroxytryptamine blocker, in portal hypertensive patients
Vorobioff J, Garcia‐Tsao G, Groszmann R, Aceves G, Picabea E, Villavicencio R, Hernandez‐Ortiz J. Long‐term hemodynamic effects of ketanserin, a 5‐hydroxytryptamine blocker, in portal hypertensive patients. Hepatology 1989, 9: 88-91. PMID: 2908873, DOI: 10.1002/hep.1840090114.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdultFemaleHemodynamicsHumansHypertension, PortalKetanserinLiver Cirrhosis, AlcoholicMaleMiddle AgedTime FactorsConceptsHepatic venous pressure gradientPortal hypertensive patientsVenous pressure gradientMean arterial pressureHypertensive patientsCardiac indexArterial pressureMean baseline hepatic venous pressure gradientBaseline hepatic venous pressure gradientLong-term hemodynamic effectsAcute hemodynamic studyChronic oral administrationHepatic venous pressurePoor liver functionAlcoholic cirrhosisPortal hypertensionReceptor blockersHemodynamic effectsPortal pressurePortosystemic encephalopathyChronic treatmentVenous pressureLiver functionMean doseHemodynamic studies
1988
Colchicine in the Treatment of Cirrhosis of the Liver
Kershenobich D, Vargas F, Garcia-Tsao G, Tamayo R, Gent M, Rojkind M. Colchicine in the Treatment of Cirrhosis of the Liver. New England Journal Of Medicine 1988, 318: 1709-1713. PMID: 3287167, DOI: 10.1056/nejm198806303182602.Peer-Reviewed Original ResearchMeSH KeywordsClinical Trials as TopicColchicineDouble-Blind MethodFemaleFollow-Up StudiesHepatitisHumansLiver CirrhosisLiver Cirrhosis, AlcoholicMaleMiddle AgedRandom AllocationConceptsTreatment of cirrhosisPlacebo groupHistologic improvementColchicine groupSurvival rateMinimal portal fibrosisPlacebo-controlled trialPercent of patientsUse of colchicineAlcoholic cirrhosisOverall survivalPortal fibrosisMore biopsiesHepatic cirrhosisLiver biopsyPosthepatitic cirrhosisHistologic studyC. FiftyCirrhosisSide effectsPatientsCollagen synthesisLiverBiopsyPreliminary evidence
1987
Hemodynamic evaluation of isosorbide dinitrate in alcoholic cirrhosis Pharmacokinetic-hemodynamic interactions
Blei A, Garcia-Tsao G, Groszmann R, Kahrilas P, Ganger D, Morse S, Fung H. Hemodynamic evaluation of isosorbide dinitrate in alcoholic cirrhosis Pharmacokinetic-hemodynamic interactions. Gastroenterology 1987, 93: 576-583. PMID: 3301517, DOI: 10.1016/0016-5085(87)90921-8.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureClinical Trials as TopicDouble-Blind MethodHemodynamicsHepatic VeinsHumansIsosorbide DinitrateKineticsLiver Cirrhosis, AlcoholicMaleMiddle AgedRandom AllocationConceptsIsosorbide dinitratePortal pressureArterial pressureHemodynamic changesHemodynamic evaluationHepatic vein wedge pressureHepatic venous gradientSystemic hemodynamic changesMean arterial pressureEffects of placeboValues 4 hStable cirrhoticsAlcoholic cirrhosisCardiac indexPortal hypertensionWedge pressureHemodynamic benefitsVenous gradientVasoactive metabolitesPharmacologic agentsIndividual patientsBaseline valuesExperimental animalsDinitratePatientsPortal hemodynamics during nitroglycerin administration in cirrhotic patients
Garcia‐Tsao G, Groszmann R. Portal hemodynamics during nitroglycerin administration in cirrhotic patients. Hepatology 1987, 7: 805-809. PMID: 3115881, DOI: 10.1002/hep.1840070502.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientVenous pressure gradientEffects of nitroglycerinMean arterial pressurePortal pressureArterial pressureNitroglycerin administrationBlood flowExperimental animalsAzygos blood flowPortal venous hemodynamicsPortal hypertensive patientsPortal blood flowVenous dilatorHypertensive patientsAlcoholic cirrhosisArterial vasodilatorCirrhotic patientsBlood pressurePortal hemodynamicsSublingual nitroglycerinVenous hemodynamicsHemodynamic responsePeak changesHeart rate
1986
Quantitative US attenuation in normal liver and in patients with diffuse liver disease: importance of fat.
Taylor K, Riely C, Hammers L, Flax S, Weltin G, Garcia-Tsao G, Conn H, Kuc R, Barwick K. Quantitative US attenuation in normal liver and in patients with diffuse liver disease: importance of fat. Radiology 1986, 160: 65-71. PMID: 3520657, DOI: 10.1148/radiology.160.1.3520657.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBiopsyCalibrationChildChild, PreschoolFatty LiverFemaleHumansLiverLiver Cirrhosis, AlcoholicLiver DiseasesMaleMiddle AgedModels, StructuralUltrasonographyShort‐term effects of propranolol on portal venous pressure
Garcia‐Tsao G, Grace N, Groszmann R, Conn H, Bermann M, Patrick M, Morse S, Alberts J. Short‐term effects of propranolol on portal venous pressure. Hepatology 1986, 6: 101-106. PMID: 3943775, DOI: 10.1002/hep.1840060119.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedFemaleHemodynamicsHumansHypertension, PortalLiver CirculationLiver Cirrhosis, AlcoholicMaleMiddle AgedPortal VeinPropranololConceptsHepatic venous pressure gradientVenous pressure gradientPropranolol plasma levelsHeart rateVenous pressurePlasma levelsMean baseline hepatic venous pressure gradientBaseline hepatic venous pressure gradientHepatic venous pressureBlood pressure responsePortal venous pressureEffect of propranololBaseline laboratoryAlcoholic cirrhosisPortal hypertensionPortal pressureLaboratory parametersLiver diseasePropranolol administrationAdditional dosesHemodynamic parametersOral administrationShort-term effectsPropranololPatients
1985
Portal pressure, presence of gastroesophageal varices and variceal bleeding
Garcia‐Tsao G, Groszmann R, Fisher R, Conn H, Atterbury C, Glickman M. Portal pressure, presence of gastroesophageal varices and variceal bleeding. Hepatology 1985, 5: 419-424. PMID: 3873388, DOI: 10.1002/hep.1840050313.Peer-Reviewed Original ResearchMeSH KeywordsEsophageal and Gastric VaricesEsophagoscopyGastrointestinal HemorrhageGastroscopyHumansLiver Cirrhosis, AlcoholicPortal VeinVenous PressureConceptsHepatic vein pressure gradientSmall varicesCirrhotic patientsPortal pressureLarge varicesSize of varicesHepatic vein catheterizationOccurrence of hemorrhagePortal pressure measurementsAlcoholic cirrhosisGastroesophageal varicesVariceal bleedingEsophagogastric varicesVariceal sizeVein catheterizationVaricesPatientsStandardized measurementsHgPressure measurementsCirrhosisBleedingCatheterizationHemorrhageEndoscopy
1981
Relationship between blood lactic acid and serum proline in alcoholic liver cirrhosis
Kershenobich D, García-Tsao G, Saldana S, Rojkind M. Relationship between blood lactic acid and serum proline in alcoholic liver cirrhosis. Gastroenterology 1981, 80: 1012-1015. PMID: 7202961, DOI: 10.1016/0016-5085(81)90074-3.Peer-Reviewed Original ResearchConceptsBlood lactic acidAlcoholic cirrhotic patientsAlcoholic liver diseaseAlcoholic cirrhoticsCirrhotic patientsLiver diseaseSerum prolineBlood lactateAlcoholic liver cirrhosisChronic liver diseaseNonalcoholic cirrhotic patientsNon-alcoholic volunteersMean control valueLiver cirrhosisAlcohol intakeAlcoholic patientsLiver damageLiver fibrogenesisAcute intoxicationCirrhoticsPatientsNormal valuesPossible markerControl valuesInhibitory effect