2019
Targets to improve quality of care for patients with hepatic encephalopathy: data from a multi‐centre cohort
Bajaj JS, O’Leary J, Tandon P, Wong F, Kamath PS, Biggins SW, Garcia‐Tsao G, Lai J, Fallon MB, Thuluvath PJ, Vargas HE, Maliakkal B, Subramanian RM, Thacker LR, Reddy KR. Targets to improve quality of care for patients with hepatic encephalopathy: data from a multi‐centre cohort. Alimentary Pharmacology & Therapeutics 2019, 49: 1518-1527. PMID: 31032966, PMCID: PMC6538445, DOI: 10.1111/apt.15265.Peer-Reviewed Original ResearchConceptsQuality of careAspiration pneumoniaEnd-stage Liver Disease cohortLiver disease cohortMulti-center cohortNorth American ConsortiumLiver transplantMELD scoreCirrhotic patientsDual therapyHepatic encephalopathyPneumonia developmentReadmission analysisBetter prognosisPatient cohortTherapy patientsDisease cohortLarge cohortPatientsMedicationsCohortAmerican ConsortiumTherapyReadmissionPneumonia
2005
Methotrexate (MTX) plus ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosis
Combes B, Emerson SS, Flye NL, Munoz SJ, Luketic VA, Mayo MJ, McCashland TM, Zetterman RK, Peters MG, Di Bisceglie AM, Benner KG, Kowdley KV, Carithers RL, Rosoff L, Garcia‐Tsao G, Boyer JL, Boyer TD, Martinez EJ, Bass NM, Lake JR, Barnes DS, Bonacini M, Lindsay KL, Mills AS, Markin RS, Rubin R, West AB, Wheeler DE, Contos MJ, Hofmann AF. Methotrexate (MTX) plus ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosis. Hepatology 2005, 42: 1184-1193. PMID: 16250039, DOI: 10.1002/hep.20897.Peer-Reviewed Original ResearchConceptsPrimary biliary cirrhosisUrsodeoxycholic acidVariceal bleedingBiliary cirrhosisTreatment failureSerum bilirubinHistological stagingCourse of PBCM2 body surface areaData Safety Monitoring BoardAMA-positive patientsReasons of futilityFailure of treatmentDevelopment of ascitesBody surface areaSafety monitoring boardEffect of methotrexateLiver transplantationPositive patientsMulticenter trialMedian periodMedian timeHistological progressionMonitoring boardDrug toxicity
1998
Further evidence against the use of aminoglycosides in cirrhotic patients
García–Tsao G. Further evidence against the use of aminoglycosides in cirrhotic patients. Gastroenterology 1998, 114: 612-613. PMID: 9496958, DOI: 10.1016/s0016-5085(98)70551-7.Commentaries, Editorials and LettersMeSH KeywordsAnti-Bacterial AgentsCeftazidimeDrug Therapy, CombinationHumansLiver CirrhosisNetilmicinSepsis
1997
Further evidence in favor of pharmacological portal pressure reduction in the prevention of variceal hemorrhage
García-Tsao G. Further evidence in favor of pharmacological portal pressure reduction in the prevention of variceal hemorrhage. Gastroenterology 1997, 112: 1770-1771. PMID: 9136864, DOI: 10.1016/s0016-5085(97)70067-2.Peer-Reviewed Original Research
1992
SPONTANEOUS BACTERIAL PERITONITIS
Garcia-Tsao G. SPONTANEOUS BACTERIAL PERITONITIS. Gastroenterology Clinics Of North America 1992, 21: 257-275. PMID: 1568776, DOI: 10.1016/s0889-8553(21)00617-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsBacterial InfectionsCausalityDiagnosis, DifferentialDrug Therapy, CombinationHumansIncidenceLiver DiseasesPeritonitisRecurrenceConceptsLiver diseaseLow ascitic fluid protein concentrationIntravenous broad-spectrum antibioticsAscitic fluid protein concentrationEpisode of SBPInfection of ascitesAdvanced liver diseaseThird of patientsBroad-spectrum antibioticsLong-term survivalFluid protein concentrationHepatic reticuloendothelial systemDiagnostic paracentesisSPONTANEOUS BACTERIALAbdominal painProphylactic antibioticsAcute episodeCirrhotic patientsGram-negative enteric bacteriaPeripheral destructionPMN countCompatible symptomsEarly therapyCirrhotic ascitesInfectious source
1989
Association of transdermal nitroglycerin to vasopressin infusion in the treatment of variceal hemorrhage: A placebo‐controlled clinical trial
Bosch J, Groszmann R, García‐Pagán J, Terés J, García‐Tsao G, Navasa M, Mas A, Rodés J. Association of transdermal nitroglycerin to vasopressin infusion in the treatment of variceal hemorrhage: A placebo‐controlled clinical trial. Hepatology 1989, 10: 962-968. PMID: 2511136, DOI: 10.1002/hep.1840100612.Peer-Reviewed Original ResearchConceptsTransdermal nitroglycerinVariceal hemorrhageVariceal bleedingPlacebo-controlled clinical trialActive variceal bleedingEffectiveness of vasopressinDouble-blind techniqueSlow-release preparationHospital mortalityTransfusion requirementsRecurrent bleedingBalloon tamponadeCirrhotic patientsEmergency surgeryVasopressin infusionClinical trialsDefinitive controlDrug combinationsTotal doseNitroglycerinBleedingHemorrhagePatientsInitial controlVasopressin