2012
Effect of Cardiac Resynchronization Therapy on the Risk of First and Recurrent Ventricular Tachyarrhythmic Events in MADIT-CRT
Ouellet G, Huang DT, Moss AJ, Hall WJ, Barsheshet A, McNitt S, Klein H, Zareba W, Goldenberg I. Effect of Cardiac Resynchronization Therapy on the Risk of First and Recurrent Ventricular Tachyarrhythmic Events in MADIT-CRT. Journal Of The American College Of Cardiology 2012, 60: 1809-1816. PMID: 23040580, DOI: 10.1016/j.jacc.2012.05.057.Peer-Reviewed Original ResearchConceptsLeft bundle branch blockVentricular tachyarrhythmic eventsNon-LBBB patientsFirst arrhythmic eventCardiac resynchronization therapyMADIT-CRTResynchronization therapyArrhythmic riskTachyarrhythmic eventsArrhythmic eventsSubsequent heart failureCRT-D therapyBundle branch blockCox proportional hazardsRisk of FirstHeart failureActive treatmentEfficacy analysisBranch blockPatientsProportional hazardsMultivariate analysisTherapyRegression modelingRiskEffectiveness of Cardiac Resynchronization Therapy in Diabetic Patients with Ischemic and Nonischemic Cardiomyopathy
George J, Barsheshet A, Moss AJ, Martin D, Ouellet G, McNitt S, Goldenberg I. Effectiveness of Cardiac Resynchronization Therapy in Diabetic Patients with Ischemic and Nonischemic Cardiomyopathy. Annals Of Noninvasive Electrocardiology 2012, 17: 14-21. PMID: 22276624, PMCID: PMC6932461, DOI: 10.1111/j.1542-474x.2011.00476.x.Peer-Reviewed Original ResearchConceptsNonischemic cardiomyopathyDiabetes mellitusProportional hazards regression modelingCardiac resynchronization therapyMADIT-CRTClinical responseEchocardiographic responseNonischemic patientsDiabetic patientsDM patientsResynchronization therapyClinical benefitCardiomyopathyPatientsRegression modelingCRTMellitusResponseTherapyDefibrillator
2011
Mutation and gender-specific risk in type 2 long QT syndrome: Implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome
Migdalovich D, Moss AJ, Lopes CM, Costa J, Ouellet G, Barsheshet A, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I. Mutation and gender-specific risk in type 2 long QT syndrome: Implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome. Heart Rhythm 2011, 8: 1537-1543. PMID: 21440677, PMCID: PMC4028036, DOI: 10.1016/j.hrthm.2011.03.049.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChi-Square DistributionChildChild, PreschoolDeath, Sudden, CardiacERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsFemaleHeart ArrestHumansInfantInfant, NewbornLong QT SyndromeMaleMutationProbabilityProportional Hazards ModelsRegistriesRisk AssessmentSex FactorsStatistics, NonparametricSurvival AnalysisConceptsLife-threatening cardiac eventsCardiac eventsLong QT syndromeGender-specific riskRisk stratificationQT syndromeKCNH2 channelsImproved risk stratificationType 2 long QT syndromeAge 40 yearsLife-threatening eventsLQT2 womenFemale patientsHigh riskLQT2 patientsTime-dependent differencesMultivariate analysisPatientsCombined assessmentCumulative probabilityWomenDisease-causing mutationsLoop mutationsMenRisk
2010
Long QT Syndrome in African‐Americans
Fugate T, Moss AJ, Jons C, McNitt S, Mullally J, Ouellet G, Goldenberg I, Zareba W, Robinson JL, Investigators F. Long QT Syndrome in African‐Americans. Annals Of Noninvasive Electrocardiology 2010, 15: 73-76. PMID: 20146785, PMCID: PMC4028024, DOI: 10.1111/j.1542-474x.2009.00342.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic beta-AntagonistsAdultAge DistributionBlack or African AmericanChildChild, PreschoolDeath, Sudden, CardiacFemaleHeart ArrestHumansInfantInfant, NewbornKaplan-Meier EstimateLong QT SyndromeMaleProportional Hazards ModelsRegistriesRisk FactorsSyncopeUnited StatesWhite PeopleYoung AdultConceptsLong QT syndromeClinical courseRisk factorsQT syndromeAfrican AmericansBeta-blocker therapyCardiac event rateComparable risk factorsKaplan-Meier timeSudden cardiac deathAge 40 yearsAfrican American patientsCox regression modelInternational LQTS RegistryOccurrence of syncopeRisk factor evaluationDecade of birthCardiac eventsCardiac deathCox analysisCardiac arrestLQTS RegistryMedical historyRacial groupsLQTS patients