2012
Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome
Costa J, Lopes CM, Barsheshet A, Moss AJ, Migdalovich D, Ouellet G, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I. Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome. Heart Rhythm 2012, 9: 892-898. PMID: 22293141, PMCID: PMC3358462, DOI: 10.1016/j.hrthm.2012.01.020.Peer-Reviewed Original ResearchConceptsCardiac eventsLife-threatening cardiac eventsSex-specific risk factorsSex-specific riskAge 40 yearsLife-threatening eventsType 1 long QT syndromeLong QT syndromeRisk stratificationRisk factorsQT intervalHigh riskTime-dependent differencesQT syndromeMultivariate analysisLQT1WomenCombined assessmentKCNQ1 geneDisease-causing mutationsMenRiskOnset of adolescenceMutation-specific informationSCD
2009
Clinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During Infancy
Spazzolini C, Mullally J, Moss AJ, Schwartz PJ, McNitt S, Ouellet G, Fugate T, Goldenberg I, Jons C, Zareba W, Robinson JL, Ackerman MJ, Benhorin J, Crotti L, Kaufman ES, Locati EH, Qi M, Napolitano C, Priori SG, Towbin JA, Vincent GM. Clinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During Infancy. Journal Of The American College Of Cardiology 2009, 54: 832-837. PMID: 19695463, PMCID: PMC3517782, DOI: 10.1016/j.jacc.2009.05.029.Peer-Reviewed Original ResearchConceptsSudden cardiac deathLong QT syndromeCardiac eventsQT syndromeHeart rateClinical implicationsFirst yearBeta-blocker therapyHigh-risk subsetInternational LQTS RegistryBeats/minAge 1 yearYears of lifeHazard ratioCardiac deathSyncopal episodesCardiac arrestLQTS RegistryFemale sexPrognostic aspectsQT intervalStudy populationHigh riskPatientsSyndrome