2024
Randomized Controlled Trial of Integrated Adherence Support to Improve Treatment Outcomes in Patients With Drug-resistant Tuberculosis and HIV
Perumal R, Wolf A, Zelnick J, Friedland G, Amico R, Daftary A, Boodhram R, Padayatchi N, Naidoo K, O'Donnell M. Randomized Controlled Trial of Integrated Adherence Support to Improve Treatment Outcomes in Patients With Drug-resistant Tuberculosis and HIV. 2024, a6948-a6948. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6948.Peer-Reviewed Original ResearchBrief Report: Differentiated Service Delivery Framework for People With Multidrug-Resistant Tuberculosis and HIV Coinfection
Reis K, Wolf A, Perumal R, Seepamore B, Guzman K, Ross J, Cheung Y, Amico K, Brust J, Padayatchi N, Friedland G, Naidoo K, Daftary A, Zelnick J, O'Donnell M. Brief Report: Differentiated Service Delivery Framework for People With Multidrug-Resistant Tuberculosis and HIV Coinfection. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2024, 96: 34-39. PMID: 38323838, PMCID: PMC11300702, DOI: 10.1097/qai.0000000000003394.Peer-Reviewed Original ResearchMultidrug-resistant tuberculosisDifferentiated service deliveryAntiretroviral therapyElectronic dose monitoring devicesAntiretroviral therapy adherenceMultidrug-resistant tuberculosis treatmentDifferentiated service delivery modelsHIV co-infectionTreatment courseCumulative adherenceTreatment challengesCo-infectionBedaquilineTreatment completionFocus groupsMedication adherenceHIVTreatmentPatterns of medication adherenceAdherenceTuberculosisSubpopulationsHIV/AIDSTreatment stageStage-specific
2019
Opportunities for community health workers to contribute to global efforts to end tuberculosis
Sinha P, Shenoi SV, Friedland GH. Opportunities for community health workers to contribute to global efforts to end tuberculosis. Global Public Health 2019, 15: 474-484. PMID: 31516079, PMCID: PMC7028491, DOI: 10.1080/17441692.2019.1663361.Peer-Reviewed Original Research
2018
Training social workers to enhance patient-centered care for drug-resistant TB-HIV in South Africa
Zelnick J, Seepamore B, Daftary A, Amico K, Bhengu X, Friedland G, Padayatchi N, Naidoo K, O'Donnell M. Training social workers to enhance patient-centered care for drug-resistant TB-HIV in South Africa. Public Health Action 2018, 8: 25-27. PMID: 29581940, PMCID: PMC5858062, DOI: 10.5588/pha.17.0114.Peer-Reviewed Original ResearchDrug-resistant tuberculosisHuman immunodeficiency virusPatient-centered careHIV coinfectionSupport group facilitationTB-HIVHIV outcomesMedication adherenceImmunodeficiency virusTreatment literacyQuestionnaire scoresCareSocial workersTraining interventionBrief training interventionCoinfectionLower ratesTraining coursesPilot training courseKwaZulu-NatalUnique roleTuberculosisWorkersCourse
2017
A patient with central nervous system tuberculomas and a history of disseminated multi-drug-resistant tuberculosis
Kaplan SR, Topal J, Sosa L, Malinis M, Huttner A, Malhotra A, Friedland G. A patient with central nervous system tuberculomas and a history of disseminated multi-drug-resistant tuberculosis. Journal Of Clinical Tuberculosis And Other Mycobacterial Diseases 2017, 10: 9-16. PMID: 31720380, PMCID: PMC6830180, DOI: 10.1016/j.jctube.2017.12.004.Peer-Reviewed Case Reports and Technical NotesDrug-resistant tuberculosisResistant tuberculosisMulti-drug resistant (MDR) TBCentral nervous system tuberculomasCentral nervous system tuberculosisNervous system tuberculosisGlobal public health concernCause of deathIncrease of patientsDrug-resistant strainsPublic health concernExtrapulmonary diseaseMiddle-income countriesNeurological symptomsTreatment challengesTuberculosisHealth concernYoung menPatientsTuberculomaSymptomsDiseaseTurning the tide against tuberculosis
Padayatchi N, Naidu N, Friedland G, Naidoo K, Conradie F, Naidoo K, O’Donnell M. Turning the tide against tuberculosis. International Journal Of Infectious Diseases 2017, 56: 6-9. PMID: 28167256, DOI: 10.1016/j.ijid.2017.01.012.Peer-Reviewed Original Research
2014
Improved survival in multidrug-resistant tuberculosis patients receiving integrated tuberculosis and antiretroviral treatment in the SAPiT Trial
Padayatchi N, Abdool Karim SS, Naidoo K, Grobler A, Friedland G. Improved survival in multidrug-resistant tuberculosis patients receiving integrated tuberculosis and antiretroviral treatment in the SAPiT Trial. The International Journal Of Tuberculosis And Lung Disease 2014, 18: 147-154. PMID: 24429305, PMCID: PMC4770013, DOI: 10.5588/ijtld.13.0627.Peer-Reviewed Original ResearchConceptsMultidrug-resistant tuberculosisMDR-TB patientsSequential treatment armAnti-tuberculosis treatmentAntiretroviral treatmentTreatment armsFirst-line anti-tuberculosis treatmentMultidrug-resistant tuberculosis patientsHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionOut-patient clinicDrug susceptibility resultsSAPiT trialTuberculosis patientsClinical outcomesEarly initiationTherapeutic effectVirus infectionMortality ratePatientsTherapeutic outcomesSmall sample sizeTreatmentSusceptibility resultsTuberculosis
2013
Adverse Events in an Integrated Home-Based Treatment Program for MDR-TB and HIV in KwaZulu-Natal, South Africa
Brust JC, Shah NS, van der Merwe TL, Bamber S, Ning Y, Heo M, Moll AP, Loveday M, Lalloo UG, Friedland GH, Gandhi NR. Adverse Events in an Integrated Home-Based Treatment Program for MDR-TB and HIV in KwaZulu-Natal, South Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 62: 436-440. PMID: 23254152, PMCID: PMC3641171, DOI: 10.1097/qai.0b013e31828175ed.Peer-Reviewed Original ResearchConceptsMultidrug-resistant tuberculosisAdverse eventsAntiretroviral therapyCommon severe adverse eventsMDR-TB/HIVTreatment programConcurrent antiretroviral therapyMDR-TB patientsMDR-TB therapySevere adverse eventsHome-based treatment programHome-based care settingsRural KwaZulu-NatalMost patientsTherapy modificationConcurrent treatmentCare settingsHIVPatientsTherapyKwaZulu-NatalIntegrated HomeTolerabilityHypothyroidismTuberculosis‘Cough officer’ nurses in a general medical clinic successfully detect drug-susceptible and -resistant tuberculosis
Shenoi SV, Brooks RP, Catterick K, Moll AP, Friedland GH. ‘Cough officer’ nurses in a general medical clinic successfully detect drug-susceptible and -resistant tuberculosis. Public Health Action 2013, 3: 46-50. PMID: 25392815, PMCID: PMC4226409, DOI: 10.5588/pha.12.0056.Peer-Reviewed Original ResearchGeneral medical clinicDrug-resistant tuberculosisMedical clinicsClinic attendeesTB suspectsHuman immunodeficiency virus (HIV) patientsHigh HIV prevalence settingsZiehl-NeelsenProportion of patientsHIV prevalence settingsCulture-positive casesResource-limited settingsWorld Health OrganizationTB screeningVirus patientsHigh HIVResistant tuberculosisPatient populationTB prevalencePrevalence settingsReferral laboratoryTuberculosisDrug resistancePatientsClinic
2012
Nosocomial Transmission of Extensively Drug-Resistant Tuberculosis in a Rural Hospital in South Africa
Gandhi NR, Weissman D, Moodley P, Ramathal M, Elson I, Kreiswirth BN, Mathema B, Shashkina E, Rothenberg R, Moll AP, Friedland G, Sturm AW, Shah NS. Nosocomial Transmission of Extensively Drug-Resistant Tuberculosis in a Rural Hospital in South Africa. The Journal Of Infectious Diseases 2012, 207: 9-17. PMID: 23166374, PMCID: PMC3523793, DOI: 10.1093/infdis/jis631.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntitubercular AgentsCluster AnalysisCross InfectionDrug Therapy, CombinationEthambutolExtensively Drug-Resistant TuberculosisFemaleGenotypeHIV InfectionsHospitals, RuralHumansIsoniazidMaleMutationMycobacterium tuberculosisPolymorphism, Restriction Fragment LengthPrevalencePyrazinamideRetrospective StudiesRifampinSequence Analysis, DNASouth AfricaConceptsDrug-resistant tuberculosisHuman immunodeficiency virusNosocomial transmissionEpidemiologic linkExtensively Drug-Resistant TuberculosisPoor infection controlSmear-positive tuberculosisMultidrug-resistant tuberculosisHigh HIV prevalencePoint-source outbreakGlobal public health threatPublic health threatResistance-determining regionXDR tuberculosisImmunodeficiency virusHIV prevalenceObservational studyInfection controlRural hospitalsPatientsTuberculosisTugela FerryFragment length polymorphism analysisHealth threatRestriction fragment length polymorphism analysisSurvival from XDR-TB Is Associated with Modifiable Clinical Characteristics in Rural South Africa
Shenoi SV, Brooks RP, Barbour R, Altice FL, Zelterman D, Moll AP, Master I, van der Merwe TL, Friedland GH. Survival from XDR-TB Is Associated with Modifiable Clinical Characteristics in Rural South Africa. PLOS ONE 2012, 7: e31786. PMID: 22412840, PMCID: PMC3295798, DOI: 10.1371/journal.pone.0031786.Peer-Reviewed Original ResearchConceptsXDR-TB patientsDrug-resistant tuberculosisRetrospective case-control studyXDR-TB casesCommunity-based hospitalCase-control studyGlobal public healthHIV coinfectionMicrobiological correlatesModifiable factorsAvailable interventionsRural South AfricaControl studyPatientsTuberculosisPublic healthSurvivorsSurvivalDaysHospitalMortalityTuberculosis infection control in a high drug-resistance setting in rural South Africa: Information, motivation, and behavioral skills
Kanjee Z, Amico KR, Li F, Mbolekwa K, Moll AP, Friedland GH. Tuberculosis infection control in a high drug-resistance setting in rural South Africa: Information, motivation, and behavioral skills. Journal Of Infection And Public Health 2012, 5: 67-81. PMID: 22341846, DOI: 10.1016/j.jiph.2011.10.008.Peer-Reviewed Original ResearchConceptsTB infection controlRural South African hospitalSouth African hospitalsInfection controlHIV statusAfrican hospitalsTuberculosis infection controlDrug-resistant tuberculosisBehavioral skillsCough hygieneSocial support itemsPresent studyRural South AfricaResource-limited facilitiesHigh-risk areasAnonymous questionnaireIMB modelTuberculosisRespondents' knowledgeSuch interventionsHospitalHCWsIC practicesMost respondentsSocial support
2011
Social Network And Molecular Analysis To Evaluate Hospital Transmission Of Extensively Drug-Resistant Tuberculosis (XDR TB) In South Africa
Shah S, Rothenberg R, Weissman D, Moodley P, Sturm A, Friedland G, Kreiswirth B, Mathema B, Ramtahal M, Vogenthaler N, Moll A, GANDHI N. Social Network And Molecular Analysis To Evaluate Hospital Transmission Of Extensively Drug-Resistant Tuberculosis (XDR TB) In South Africa. 2011, a5307-a5307. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5307.Peer-Reviewed Original ResearchMycobacterium Tuberculosis Resistant To Nine First- And Second-Line TB Drugs In An HIV-Infected Child From Rural South Africa
Thomas T, Heysell S, Eksteen F, Moodley P, Moll A, Sturm A, Friedland G, Shah S. Mycobacterium Tuberculosis Resistant To Nine First- And Second-Line TB Drugs In An HIV-Infected Child From Rural South Africa. 2011, a5714-a5714. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5714.Peer-Reviewed Original ResearchIncreasing Drug Resistance in Extensively Drug-Resistant Tuberculosis, South Africa - Volume 17, Number 3—March 2011 - Emerging Infectious Diseases journal - CDC
Shah NS, Richardson J, Moodley P, Moodley S, Babaria P, Ramtahal M, Heysell SK, Li X, Moll AP, Friedland G, Sturm AW, Gandhi NR. Increasing Drug Resistance in Extensively Drug-Resistant Tuberculosis, South Africa - Volume 17, Number 3—March 2011 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2011, 17: 510-513. PMID: 21392446, PMCID: PMC3166021, DOI: 10.3201/eid1703.101363.Peer-Reviewed Original ResearchConceptsExtensively Drug-Resistant TuberculosisTuberculosis drug susceptibility testingDrug-resistant Mycobacterium tuberculosisInfectious Diseases journal - CDCDrug-resistant TBDrug-resistant tuberculosisDrug susceptibility testingEffective treatmentAvailable drugsDrug resistanceSusceptibility testingMycobacterium tuberculosisTuberculosisDrugsPatients
2010
Blood cultures for the diagnosis of multidrug-resistant and extensively drug-resistant tuberculosis among HIV-infected patients from rural South Africa: a cross-sectional study
Heysell SK, Thomas TA, Gandhi NR, Moll AP, Eksteen FJ, Coovadia Y, Roux L, Babaria P, Lalloo U, Friedland G, Shah S. Blood cultures for the diagnosis of multidrug-resistant and extensively drug-resistant tuberculosis among HIV-infected patients from rural South Africa: a cross-sectional study. BMC Infectious Diseases 2010, 10: 344. PMID: 21134279, PMCID: PMC3016377, DOI: 10.1186/1471-2334-10-344.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAIDS-Related Opportunistic InfectionsChildChild, PreschoolCross-Sectional StudiesExtensively Drug-Resistant TuberculosisFemaleHIV InfectionsHumansInfantInfant, NewbornMaleMiddle AgedMycobacterium tuberculosisRetrospective StudiesRisk FactorsRural PopulationSouth AfricaSputumYoung AdultConceptsDrug-resistant TBMycobacterial blood culturesDrug-resistant tuberculosisBlood culturesXDR-TBRural South AfricaMDR-TBM. tuberculosisMycobacterium tuberculosis bacteremiaCross-sectional studyPositive blood culturesDiagnosis of MDRCross-sectional analysisAntiretroviral therapySecondary outcomesSputum cultureTB suspectsRisk factorsPatientsHIVTuberculosisDiagnosisTBSimilar settingsBacteremiaThe SAPIT trial provides essential evidence on risks and benefits of integrated and sequential treatment of HIV and tuberculosis
Karim Q, Karim S, Baxter C, Friedland G, Gengiah T, Gray A, Grobler A, Naidoo K, Padayatchi N, El-Sadr W. The SAPIT trial provides essential evidence on risks and benefits of integrated and sequential treatment of HIV and tuberculosis. South African Medical Journal 2010, 100: 808-809. PMID: 21414268, DOI: 10.7196/samj.4621.Peer-Reviewed Original ResearchPharmacokinetics and Whole-Blood Bactericidal Activity against Mycobacterium tuberculosis of Single Doses of PNU-100480 in Healthy Volunteers
Wallis RS, Jakubiec WM, Kumar V, Silvia AM, Paige D, Dimitrova D, Li X, Ladutko L, Campbell S, Friedland G, Mitton-Fry M, Miller PF. Pharmacokinetics and Whole-Blood Bactericidal Activity against Mycobacterium tuberculosis of Single Doses of PNU-100480 in Healthy Volunteers. The Journal Of Infectious Diseases 2010, 202: 745-751. PMID: 20629533, DOI: 10.1086/655471.Peer-Reviewed Original ResearchConceptsWhole-blood bactericidal activityMean maximal concentrationPNU-100480Single dosesMinimum inhibitory concentrationHealthy volunteersBactericidal activityMycobacterium tuberculosisExperimental murine tuberculosisSingle ascending dosesSingle oral dosesDrug-resistant tuberculosisMaximal concentrationInhibitory concentrationAscending dosesMurine tuberculosisExposure of parentsOral dosesDaily dosesLog/dayLinezolidDrug concentrationsTuberculosisMycobactericidal activityDosesTransmission of Drug-Susceptible and Drug-Resistant Tuberculosis and the Critical Importance of Airborne Infection Control in the Era of HIV Infection and Highly Active Antiretroviral Therapy Rollouts
Shenoi SV, Escombe AR, Friedland G. Transmission of Drug-Susceptible and Drug-Resistant Tuberculosis and the Critical Importance of Airborne Infection Control in the Era of HIV Infection and Highly Active Antiretroviral Therapy Rollouts. Clinical Infectious Diseases 2010, 50: s231-s237. PMID: 20397953, PMCID: PMC3029014, DOI: 10.1086/651496.Peer-Reviewed Original ResearchConceptsInfection control strategiesResource-limited settingsHIV infectionInfection controlActive antiretroviral therapy rolloutHuman immunodeficiency virus (HIV) infectionAntiretroviral therapy rolloutTransmission of drugDrug-resistant TBImmunodeficiency virus infectionDrug-resistant tuberculosisHealth care workersAirborne infection controlNosocomial transmissionTuberculosis careVirus infectionCare workersInfectionCurrent outbreakHigh rateTBPotential benefitsMorbidityHIVTuberculosisRapid Diagnosis Of Tuberculosis And MDR TB Using The Microscopic-Observation Drug-Susceptibility (MODS) Assay In A High HIV Prevalence Setting – South Africa
Shah S, Babaria P, Moodley P, Heysell S, Sturm W, Moll A, Mhlongo P, Moodley S, Ramtahal M, Richardson J, Li X, Friedland G, Gandhi N. Rapid Diagnosis Of Tuberculosis And MDR TB Using The Microscopic-Observation Drug-Susceptibility (MODS) Assay In A High HIV Prevalence Setting – South Africa. 2010, a2256-a2256. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2256.Peer-Reviewed Original Research