2011
Spread of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal Province, South Africa
Moodley P, Shah NS, Tayob N, Connolly C, Zetola N, Gandhi N, Friedland G, Sturm AW. Spread of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal Province, South Africa. PLOS ONE 2011, 6: e17513. PMID: 21655324, PMCID: PMC3104985, DOI: 10.1371/journal.pone.0017513.Peer-Reviewed Original ResearchConceptsMDR-TB casesDrug-resistant tuberculosisXDR-TB casesXDR-TBDrug susceptibility test resultsExtensively Drug-Resistant TuberculosisMDR tuberculosis casesMDR-TB patientsXDR-TB patientsCulture-confirmed casesProvincial referral hospitalCross-sectional studyKwaZulu-Natal ProvinceSource of infectionTB casesNumber of hospitalsReferral hospitalSputum cultureTuberculosis casesScotland hospitalsPatientsHealthcare districtsHospitalClinical diagnosisLaboratory databaseCulture Conversion Among HIV Co-Infected Multidrug-Resistant Tuberculosis Patients in Tugela Ferry, South Africa
Brust JC, Lygizos M, Chaiyachati K, Scott M, van der Merwe TL, Moll AP, Li X, Loveday M, Bamber SA, Lalloo UG, Friedland GH, Shah NS, Gandhi NR. Culture Conversion Among HIV Co-Infected Multidrug-Resistant Tuberculosis Patients in Tugela Ferry, South Africa. PLOS ONE 2011, 6: e15841. PMID: 21253585, PMCID: PMC3017058, DOI: 10.1371/journal.pone.0015841.Peer-Reviewed Original ResearchConceptsMDR-TB patientsCulture conversion rateMDR-TB treatmentMonths of therapyAntiretroviral therapyHIV-coCulture conversionHIV co-infected patientsMultidrug-resistant tuberculosis patientsTiming of ARTMDR-TB therapyCo-infected patientsHIV-negative patientsSecond-line regimenSimilar cure ratesDays of initiationResource-limited settingsHIV prevalentART medicationsCD4 countMDR-TBTuberculosis patientsSputum cultureSuch patientsHIV status
2010
Blood cultures for the diagnosis of multidrug-resistant and extensively drug-resistant tuberculosis among HIV-infected patients from rural South Africa: a cross-sectional study
Heysell SK, Thomas TA, Gandhi NR, Moll AP, Eksteen FJ, Coovadia Y, Roux L, Babaria P, Lalloo U, Friedland G, Shah S. Blood cultures for the diagnosis of multidrug-resistant and extensively drug-resistant tuberculosis among HIV-infected patients from rural South Africa: a cross-sectional study. BMC Infectious Diseases 2010, 10: 344. PMID: 21134279, PMCID: PMC3016377, DOI: 10.1186/1471-2334-10-344.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAIDS-Related Opportunistic InfectionsChildChild, PreschoolCross-Sectional StudiesExtensively Drug-Resistant TuberculosisFemaleHIV InfectionsHumansInfantInfant, NewbornMaleMiddle AgedMycobacterium tuberculosisRetrospective StudiesRisk FactorsRural PopulationSouth AfricaSputumYoung AdultConceptsDrug-resistant TBMycobacterial blood culturesDrug-resistant tuberculosisBlood culturesXDR-TBRural South AfricaMDR-TBM. tuberculosisMycobacterium tuberculosis bacteremiaCross-sectional studyPositive blood culturesDiagnosis of MDRCross-sectional analysisAntiretroviral therapySecondary outcomesSputum cultureTB suspectsRisk factorsPatientsHIVTuberculosisDiagnosisTBSimilar settingsBacteremia
2006
Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa
Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, Lalloo U, Zeller K, Andrews J, Friedland G. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. The Lancet 2006, 368: 1575-1580. PMID: 17084757, DOI: 10.1016/s0140-6736(06)69573-1.Peer-Reviewed Original ResearchConceptsDrug-resistant tuberculosisCo-infected patientsXDR tuberculosisMDR tuberculosisHIV co-infected patientsCulture-confirmed tuberculosisRecent hospital admissionTime of diagnosisSecond-line drugsDrug susceptibility testingCause of deathDate of deathHigh mortality rateAntiretroviral therapyMedian survivalHospital admissionSputum cultureHIV-1PatientsMortality rateHigh mortalityUrgent interventionTreatment programTuberculosisSusceptibility testing