2024
Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival
Zaman S, Gorelick F, Chrobrutskiy A, Chobrutskiy B, Desir G, Blanck G. Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival. Oncotarget 2024, 15: 550-561. PMID: 39102218, PMCID: PMC11299663, DOI: 10.18632/oncotarget.28633.Peer-Reviewed Original ResearchConceptsT cell receptorOverall survivalT cellsAssociated with improved overall survivalT-cell receptor CDR3sPromote T cell activationImproved overall survivalSurvival of melanomaPancreatic cancer patientsT cell activationT cell receptor recognitionTumor-residentTumor rejectionMelanoma patientsMelanoma growthMelanoma survivalImmune signature genesSurvival associationsCancer patientsMelanomaSignature genesAmino acid sequenceSurvivalPatientsExpression levels
2023
An AI-powered patient triage platform for future viral outbreaks using COVID-19 as a disease model
Charkoftaki G, Aalizadeh R, Santos-Neto A, Tan W, Davidson E, Nikolopoulou V, Wang Y, Thompson B, Furnary T, Chen Y, Wunder E, Coppi A, Schulz W, Iwasaki A, Pierce R, Cruz C, Desir G, Kaminski N, Farhadian S, Veselkov K, Datta R, Campbell M, Thomaidis N, Ko A, Thompson D, Vasiliou V. An AI-powered patient triage platform for future viral outbreaks using COVID-19 as a disease model. Human Genomics 2023, 17: 80. PMID: 37641126, PMCID: PMC10463861, DOI: 10.1186/s40246-023-00521-4.Peer-Reviewed Original ResearchConceptsCOVID-19 patientsDisease severityViral outbreaksFuture viral outbreaksLength of hospitalizationIntensive care unitWorse disease prognosisLife-threatening illnessEffective medical interventionsCOVID-19Clinical decision treeGlucuronic acid metabolitesNew potential biomarkersHospitalization lengthCare unitComorbidity dataSerotonin levelsDisease progressionHealthy controlsPatient outcomesDisease prognosisPatient transferPatientsHealthcare resourcesPotential biomarkersPlasma renalase levels are associated with the development of acute pancreatitis
Wang M, Weiss F, Guo X, Kolodecik T, Bewersdorf J, Laine L, Lerch M, Desir G, Gorelick F. Plasma renalase levels are associated with the development of acute pancreatitis. Pancreatology 2023, 23: 158-162. PMID: 36697349, DOI: 10.1016/j.pan.2023.01.001.Peer-Reviewed Original ResearchConceptsAcute pancreatitisSevere diseasePlasma renalase levelsAcute pancreatitis patientsSevere acute pancreatitisAcute pancreatitis modelPlasma renalaseRenalase levelsSignificant morbidityPancreatitis patientsPlasma levelsHealthy controlsPancreatitis modelPancreatitisPatientsPlasma samplesRenalaseDiseaseNonparametric statistical analysisSecretory proteinsMorbidityStatistical analysisMortalityLevels
2013
Renalase in hypertension and kidney disease
Desir GV, Peixoto AJ. Renalase in hypertension and kidney disease. Nephrology Dialysis Transplantation 2013, 29: 22-28. PMID: 24137013, DOI: 10.1093/ndt/gft083.Peer-Reviewed Original ResearchDoes Kidney Disease Cause Hypertension?
Peixoto AJ, Orias M, Desir GV. Does Kidney Disease Cause Hypertension? Current Hypertension Reports 2013, 15: 89-94. PMID: 23344662, DOI: 10.1007/s11906-013-0327-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic kidney diseaseKidney diseaseRenal functionStructural kidney diseaseGlomerular filtration ratePlasmin-mediated activationExtracellular fluid volumeProteinuric glomerular diseasesPolycystic kidney diseaseChronic hypertensionHypertension increasesEpithelial sodium channelSodium retentionFiltration rateGlomerular diseaseHypertensionCurrent evidenceDiseaseSodium channelsFluid volumeDetectable changeSevere reductionMost casesProteinuriaPatients
2009
A Case of Extreme Hemodynamic Lability and Hypocalcemia
Knauf F, Desir GV, Perazella MA. A Case of Extreme Hemodynamic Lability and Hypocalcemia. The American Journal Of The Medical Sciences 2009, 338: 241-244. PMID: 19590425, DOI: 10.1097/maj.0b013e3181a66af1.Peer-Reviewed Original ResearchRegulation of blood pressure and cardiovascular function by renalase
Desir GV. Regulation of blood pressure and cardiovascular function by renalase. Kidney International 2009, 76: 366-370. PMID: 19471322, DOI: 10.1038/ki.2009.169.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseGlomerular filtration rateBlood pressureKidney diseasePlasma catecholaminesCardiovascular functionKnockout miceEnd-stage kidney diseaseRenalase knockout mouseSingle nucleotide polymorphismsRenalase levelsCardiovascular riskEssential hypertensionFiltration rateCardiac functionCardiac ischemiaRenalase geneSignificant fallAnimal modelsRenalaseCatecholaminesHypertensionPatientsFold stimulationAbnormalities
1987
568 Detection of Acute Allograft Rejection by Indium-111 Labeled Platelet Scintigraphy in Renal Transplant Patients
Bia M, Desir G, Ezekowitz M, Lange R, Smith E, Kashgarian M, Schiff M. 568 Detection of Acute Allograft Rejection by Indium-111 Labeled Platelet Scintigraphy in Renal Transplant Patients. Journal Of Urology 1987, 137: 245a. DOI: 10.1016/s0022-5347(17)75718-7.Peer-Reviewed Original ResearchDetection of acute allograft rejection by indium-111 labeled platelet scintigraphy in renal transplant patients.
Desir G, Bia MJ, Lange RC, Smith EO, Kashgarian M, Flye W, Schiff M, Ezekowitz MD. Detection of acute allograft rejection by indium-111 labeled platelet scintigraphy in renal transplant patients. Transplantation Proceedings 1987, 19: 1677-80. PMID: 3547876.Peer-Reviewed Original Research
1986
Haemophilus parainfluenzae Liver Abscess in a Recipient of a Renal Transplant Who Had Polycystic Disease
Desir G, Helman D, Herlich M, Turka L, Bia M. Haemophilus parainfluenzae Liver Abscess in a Recipient of a Renal Transplant Who Had Polycystic Disease. JAMA 1986, 255: 1878-1878. PMID: 3512876, DOI: 10.1001/jama.1986.03370140076015.Peer-Reviewed Original ResearchConceptsPolycystic kidney diseaseKidney diseaseCyst infectionLiver cystsPersistent hepatitis B surface antigenemiaHepatitis B surface antigenemiaHepatitis B virus infectionLiver cyst infectionB virus infectionRenal cyst infectionAutosomal dominant polycystic kidney diseaseDominant polycystic kidney diseaseOne-month courseImmunosuppressive therapyKidney transplantationSurface antigenemiaRenal failurePercutaneous drainageCurrent admissionVirus infectionPolycystic kidneysThird monthPatientsHaemophilus parainfluenzaeEnteric organisms