2024
A qualitative dyad analysis of barriers and facilitators of antiretroviral therapy (ART) adherence among people who inject drugs (PWID) with HIV in Kazakhstan
Neuenschwander P, Altice F, Remien R, Mergenova G, Sarsembayeva L, Rozental E, Gulyayev V, Davis A. A qualitative dyad analysis of barriers and facilitators of antiretroviral therapy (ART) adherence among people who inject drugs (PWID) with HIV in Kazakhstan. AIDS Care 2024, ahead-of-print: 1-10. PMID: 39404196, DOI: 10.1080/09540121.2024.2414078.Peer-Reviewed Original ResearchAntiretroviral therapy adherenceSocial supportART adherenceFacilitators of ART adherenceBarriers to ART adherenceAntiretroviral therapyART adherence interventionsInjection drug useDyad analysisAdherence interventionsAdherence barriersLack of awarenessHIV epidemicAdherencePWIDDrug useHIVInterpersonal levelRelationship contextDyad membersFacilitationIndividual levelPWHDyadsIntimate partners
2022
Implementation of a Dyad-Based Intervention to Improve Antiretroviral Therapy Adherence Among HIV-Positive People Who Inject Drugs in Kazakhstan: A Randomized Trial
Davis A, Mergenova G, Landers S, Sun Y, Rozental E, Gulyaev V, Gulyaev P, Nurkatova M, Terlikbayeva A, Primbetova S, Altice F, Remien R. Implementation of a Dyad-Based Intervention to Improve Antiretroviral Therapy Adherence Among HIV-Positive People Who Inject Drugs in Kazakhstan: A Randomized Trial. Research On Social Work Practice 2022, 33: 313-324. PMID: 37576461, PMCID: PMC10421639, DOI: 10.1177/10497315221117543.Peer-Reviewed Original ResearchHIV-positive PWIDAntiretroviral therapy adherenceHIV-positive peopleTherapy adherenceART adherence interventionsStandard of careSupport partnersART adherenceAdherence interventionsIntervention deliveryPWIDTraining of staffInterventionTrialsAdherenceCouple interventionsSocial supportFamily membersDrugsIntimate partnersRemote deliveryCollection of assessmentsImplementation strategiesDeliveryAdapted version
2020
Adherence to and Retention in Medications for Opioid Use Disorder Among Adolescents and Young Adults
Viera A, Bromberg DJ, Whittaker S, Refsland BM, Stanojlović M, Nyhan K, Altice FL. Adherence to and Retention in Medications for Opioid Use Disorder Among Adolescents and Young Adults. Epidemiologic Reviews 2020, 42: 41-56. PMID: 32239206, PMCID: PMC8087870, DOI: 10.1093/epirev/mxaa001.Peer-Reviewed Original ResearchConceptsOpioid use disorderUse disordersYoung adultsAssociation of ageFull-text reviewRetention of adolescentsConcurrent substance useNegative health outcomesMOUD retentionOpioid epidemicInclusion criteriaHealth outcomesYounger ageAge groupsMOUDSubstance useAdherenceGood evidenceAdultsMedicationsDisordersAdolescentsSearch criteriaAgeOutcomesAssessing mobile health feasibility and acceptability among HIV-infected cocaine users and their healthcare providers: guidance for implementing an intervention
Brown SE, Krishnan A, Ranjit YS, Marcus R, Altice FL. Assessing mobile health feasibility and acceptability among HIV-infected cocaine users and their healthcare providers: guidance for implementing an intervention. MHealth 2020, 6: 4-4. PMID: 32190615, PMCID: PMC7063267, DOI: 10.21037/mhealth.2019.09.12.Peer-Reviewed Original ResearchMedication adherenceHealthcare providersCocaine useFeasibility of mHealthHIV treatment outcomesCocaine usersCommunity health workersSelf-reported cocaine usePatient-provider relationshipPhone callsPharmacological treatmentText remindersTreatment outcomesHealth workersControl trialFocus groupsMHealth interventionsPatientsHIVMHealth pilotsCost-effective strategyCase managersHealth informationHealth purposesAdherence
2019
Rationale and design of an integrated bio-behavioral approach to improve adherence to pre-exposure prophylaxis and HIV risk reduction among opioid-dependent people who use drugs: The CHRP-BB study
Shrestha R, Altice FL, Sibilio B, Ssenyonjo J, Copenhaver MM. Rationale and design of an integrated bio-behavioral approach to improve adherence to pre-exposure prophylaxis and HIV risk reduction among opioid-dependent people who use drugs: The CHRP-BB study. Contemporary Clinical Trials 2019, 82: 77-84. PMID: 31229618, PMCID: PMC6639056, DOI: 10.1016/j.cct.2019.06.012.Peer-Reviewed Original ResearchConceptsBio-behavioral interventionHIV risk reductionOpioid-dependent peopleMethadone maintenance programPrEP adherenceHIV transmission risk reductionFirst prospective trialPre-exposure prophylaxisHIV prevention strategiesOngoing drug useRisk reductionBehavioral skills modelProspective trialSecondary outcomesPrimary outcomeRisk reduction outcomesHIV riskWeek 20Prevention strategiesUnmet needDrug useHybrid type IBio-behavioral approachProcess evaluationAdherenceHIV-Related Stigma, Motivation to Adhere to Antiretroviral Therapy, and Medication Adherence Among HIV-Positive Methadone-Maintained Patients
Shrestha R, Altice FL, Copenhaver MM. HIV-Related Stigma, Motivation to Adhere to Antiretroviral Therapy, and Medication Adherence Among HIV-Positive Methadone-Maintained Patients. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 80: 166-173. PMID: 30383588, PMCID: PMC6331231, DOI: 10.1097/qai.0000000000001891.Peer-Reviewed Original ResearchConceptsOptimal ART adherenceAntiretroviral therapyMethadone-maintained patientsMethadone maintenance treatmentART adherenceMaintenance treatmentHIV treatment outcomesHIV-positive patientsOpioid agonist therapyMultivariable logistic regressionHIV risk behaviorsExplanatory pathwaysAgonist therapySuboptimal adherenceMedication adherenceHIV treatmentTreatment outcomesHIV stigmaPatientsLogistic regressionHIVPrevention initiativesTherapyAdherenceSignificant correlates
2018
Adherence to Antiretroviral Therapy Among Incarcerated Persons with HIV: Associations with Methadone and Perceived Safety
Culbert GJ, Waluyo A, Wang M, Putri TA, Bazazi AR, Altice FL. Adherence to Antiretroviral Therapy Among Incarcerated Persons with HIV: Associations with Methadone and Perceived Safety. AIDS And Behavior 2018, 23: 2048-2058. PMID: 30465106, PMCID: PMC6698149, DOI: 10.1007/s10461-018-2344-6.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyART adherenceART utilizationMethadone utilizationHIV status disclosureHealth service satisfactionStatus disclosureMedical treatmentDrug dependencyPWHAdherenceMost participantsHIVMethadoneTherapyChance locusSafetyAdequate supportHigh levelsPerceived SafetyPersonal safetyIntegrated Bio-behavioral Approach to Improve Adherence to Pre-exposure Prophylaxis and Reduce HIV Risk in People Who Use Drugs: A Pilot Feasibility Study
Shrestha R, Altice FL, Karki P, Copenhaver MM. Integrated Bio-behavioral Approach to Improve Adherence to Pre-exposure Prophylaxis and Reduce HIV Risk in People Who Use Drugs: A Pilot Feasibility Study. AIDS And Behavior 2018, 22: 2640-2649. PMID: 29582199, PMCID: PMC6051885, DOI: 10.1007/s10461-018-2099-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesics, OpioidBiobehavioral SciencesCondomsFeasibility StudiesFemaleHIV InfectionsHumansMaleMedication AdherenceMethadoneMiddle AgedMotivationOpiate Substitution TreatmentOpioid-Related DisordersPatient Acceptance of Health CarePilot ProjectsPre-Exposure ProphylaxisProspective StudiesRisk Reduction BehaviorSexual BehaviorSexual PartnersSubstance Abuse, IntravenousConceptsPre-exposure prophylaxis adherenceSelf-reported PrEP adherenceSex-related risk behaviorsHIV risk reduction behaviorsBio-behavioral interventionPre-exposure prophylaxisProspective clinical trialsHigh-risk peopleHIV prevention interventionsHIV risk behaviorsPilot feasibility studyPost-intervention assessmentPrEP adherenceProphylaxis adherencePreliminary efficacyClinical trialsIntervention groupHIV riskPrevention interventionsRisk behaviorsBio-behavioral approachAdherenceInterventionHigh acceptabilityPrEP
2016
Co-calibration of two self-reported measures of adherence to antiretroviral therapy
Nance RM, Delaney JA, Golin CE, Wechsberg WM, Cunningham C, Altice F, Christopoulos K, Knight K, Quan V, Gordon MS, Springer S, Young J, Crane PK, Mayer KH, Mugavero MJ, Del Rio C, Kronmal RA, Crane HM. Co-calibration of two self-reported measures of adherence to antiretroviral therapy. AIDS Care 2016, 29: 464-468. PMID: 27910703, PMCID: PMC5291764, DOI: 10.1080/09540121.2016.1263721.Peer-Reviewed Original ResearchConceptsVisual analog scaleAntiretroviral therapyAdherence measuresAIDS Clinical Trials Group questionnaireHigh-risk vulnerable populationsVulnerable populationsCare cohortAnalog scaleVAS scaleHIV StudyAdherence dataClinical successConsortium studyGroup questionnaireTherapyDosesSelf-report measuresAdherence
2011
Substance Abuse, Violence, and HIV in Women: A Literature Review of the Syndemic
Meyer JP, Springer SA, Altice FL. Substance Abuse, Violence, and HIV in Women: A Literature Review of the Syndemic. Journal Of Women's Health 2011, 20: 991-1006. PMID: 21668380, PMCID: PMC3130513, DOI: 10.1089/jwh.2010.2328.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHIV/AIDSSubstance abuseHealthcare utilizationPoor HIV outcomesBetter health outcomesEvidence-based interventionsNegative health consequencesHIV outcomesHIV statusMedication adherenceHealth outcomesMental illnessHealth consequencesMental healthUrban womenWomenHIVBidirectional relationshipVulnerable groupsAIDSPrevention of violenceCurrent findingsAdherenceFuture studiesInconsistent definitionsComputer-Based Intervention in HIV Clinical Care Setting Improves Antiretroviral Adherence: The LifeWindows Project
Fisher JD, Amico KR, Fisher WA, Cornman DH, Shuper PA, Trayling C, Redding C, Barta W, Lemieux AF, Altice FL, Dieckhaus K, Friedland G, for the LifeWindows Team. Computer-Based Intervention in HIV Clinical Care Setting Improves Antiretroviral Adherence: The LifeWindows Project. AIDS And Behavior 2011, 15: 1635. PMID: 21452051, DOI: 10.1007/s10461-011-9926-x.Peer-Reviewed Original ResearchConceptsHIV clinical care settingsAdherence support interventionsClinical care sitesClinical care settingsHIV careCare visitsAntiretroviral adherenceControl armCare settingsCare sitesProtocol interventionTreat sampleProtocol sampleSupport interventionsComputer-based interventionsIntervention impactControl participantsInterventionAdherenceHIVPatientsCareHigh levelsClinicARVMedication persistence in the treatment of HIV infection: a review of the literature and implications for future clinical care and research
Bae JW, Guyer W, Grimm K, Altice FL. Medication persistence in the treatment of HIV infection: a review of the literature and implications for future clinical care and research. AIDS 2011, 25: 279-290. PMID: 21239892, DOI: 10.1097/qad.0b013e328340feb0.Peer-Reviewed Original ResearchConceptsClinical outcomesPrescribed therapyFuture clinical careSuboptimal persistenceVirological failureAntiretroviral resistanceMedication persistenceHIV infectionMedication treatmentHIV treatmentCertain regimensClinical consequencesClinical carePatient behaviorPatientsContinuous treatmentUnderrecognized aspectsTherapyAdherenceHIVTreatmentShort durationCurrent literatureDurationIntervention
2010
A systematic review of the impact of alcohol use disorders on HIV treatment outcomes, adherence to antiretroviral therapy and health care utilization
Azar MM, Springer SA, Meyer JP, Altice FL. A systematic review of the impact of alcohol use disorders on HIV treatment outcomes, adherence to antiretroviral therapy and health care utilization. Drug And Alcohol Dependence 2010, 112: 178-193. PMID: 20705402, PMCID: PMC2997193, DOI: 10.1016/j.drugalcdep.2010.06.014.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHealth care utilizationHIV treatment outcomesAlcohol use disorderPoor HIV treatment outcomesCare utilizationTreatment outcomesAntiretroviral therapyUse disordersImpact of AUDHealth service utilizationHIV/AIDSCD4 countHIV statusMedication adherenceService utilizationDATA SYNTHESISAnimal studiesElectronic databasesSystematic reviewAlcohol useTherapyPrimary articlesGoogle ScholarAdherenceOutcomesNeurocognitive Impairment and HIV Risk Factors: A Reciprocal Relationship
Anand P, Springer SA, Copenhaver MM, Altice FL. Neurocognitive Impairment and HIV Risk Factors: A Reciprocal Relationship. AIDS And Behavior 2010, 14: 1213-1226. PMID: 20232242, PMCID: PMC2906682, DOI: 10.1007/s10461-010-9684-1.Peer-Reviewed Original ResearchConceptsRisk reduction interventionsMedication adherenceCognitive impairmentRisk behaviorsHIV risk factorsHIV risk behaviorsImpact of HIVEffectiveness of interventionsSuboptimal adherenceRisk factorsNeurocognitive impairmentMental illnessCognitive functionSubstance abuseImpairmentAdherenceHIVInterventionReciprocal relationshipRiskSignificant barriers
2007
Initiation, Adherence, and Retention in a Randomized Controlled Trial of Directly Administered Antiretroviral Therapy
Maru DS, Bruce RD, Walton M, Mezger JA, Springer SA, Shield D, Altice FL. Initiation, Adherence, and Retention in a Randomized Controlled Trial of Directly Administered Antiretroviral Therapy. AIDS And Behavior 2007, 12: 284-293. PMID: 18085432, PMCID: PMC2693908, DOI: 10.1007/s10461-007-9336-2.Peer-Reviewed Original ResearchConceptsSelf-administered therapyAntiretroviral therapyDrug usersComposite adherence scorePresence of depressionDrug treatment programsControlled TrialsSix-month periodAdherence scoreOwn medicationsHealth outcomesDAARTMajor causeTherapyAdherenceDiscontinuationHIVSuccessful program designTrialsParticipantsHospitalizationMedicationsLack of willingnessVisits
2002
Increasing drug users’ adherence to HIV treatment: results of a peer-driven intervention feasibility study
Broadhead RS, Heckathorn DD, Altice FL, van Hulst Y, Carbone M, Friedland GH, O’Connor P, Selwyn PA. Increasing drug users’ adherence to HIV treatment: results of a peer-driven intervention feasibility study. Social Science & Medicine 2002, 55: 235-246. PMID: 12144138, DOI: 10.1016/s0277-9536(01)00167-8.Peer-Reviewed Original ResearchConceptsActive drug usersDrug users' adherenceDrug usersDrug treatmentMedical carePrimary careIntervention feasibility studySocial support structuresHealth advocatesUser adherenceTreatment program staffPeer-driven interventionHIV diseaseHIV infectionPatient adherenceSix-month studyHIV treatmentPhysician referralClinical appointmentsHIV therapeuticsCarePositive behavioral changesAdherencePeer pressureTreatment
1998
Adherence to Antiretroviral Therapy in Correctional Settings
Altice F, Buitrago M. Adherence to Antiretroviral Therapy in Correctional Settings. Journal Of Correctional Health Care 1998, 5: 179-200. DOI: 10.1177/107834589800500205.Peer-Reviewed Original ResearchAntiretroviral therapyNew antiretroviral combinationsDrug-resistant HIVLack of benefitHealth care settingsCorrectional settingsAntiretroviral combinationsClinical benefitHIV progressionCare existFaceted interventionHIV therapyCare settingsDrug usersTherapyAIDS incidenceHIVAdherenceCorrectional environmentSettingHospitalizationPatientsDramatic decreaseCliniciansIncidenceAcceptance and Adherence With Antiretroviral Therapy Among HIV-Infected Women in a Correctional Facility
Mostashari F, Riley E, Selwyn P, Altice F. Acceptance and Adherence With Antiretroviral Therapy Among HIV-Infected Women in a Correctional Facility. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1998, 18: 341-348. PMID: 9704939, DOI: 10.1097/00042560-199808010-00005.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyAntiretroviral agentsCare systemHIV-seropositive womenPresence of HIVNon-black racePatient-physician relationshipHealth care systemMedical care systemHIV careHIV medicationsMedication adherenceMedication efficacyMedication safetyHIVMultivariate analysisTherapyAdherenceHealth careWomenCareMedicationsEducational levelStructured interviewsSocial support