2023
Evaluation of Plasma Biomarkers to Predict Major Adverse Kidney Events in Hospitalized Patients With COVID-19
Menez S, Coca S, Moledina D, Wen Y, Chan L, Thiessen-Philbrook H, Obeid W, Garibaldi B, Azeloglu E, Ugwuowo U, Sperati C, Arend L, Rosenberg A, Kaushal M, Jain S, Wilson F, Parikh C, Consortium T, Deng J, Atta M, Bagnasco S, Ko A, Iwasaki A, Farhadian S, Nelson A, Casanovas-Massana A, White E, Schulz W, Coppi A, Young P, Nunez A, Shepard D, Matos I, Strong Y, Anastasio K, Brower K, Kuang M, Chiorazzi M, Bermejo S, Vijayakumar P, Geng B, Fournier J, Minasyan M, Muenker M, Moore A, Nadkarni G. Evaluation of Plasma Biomarkers to Predict Major Adverse Kidney Events in Hospitalized Patients With COVID-19. American Journal Of Kidney Diseases 2023, 82: 322-332.e1. PMID: 37263570, PMCID: PMC10229201, DOI: 10.1053/j.ajkd.2023.03.010.Peer-Reviewed Original ResearchConceptsSoluble tumor necrosis factor receptor 1Major adverse kidney eventsAdverse kidney eventsAdverse kidney outcomesAcute kidney injuryKidney eventsTumor necrosis factor receptor 1Necrosis factor receptor 1Plasma biomarkersKidney outcomesC-indexFactor receptor 1Hospitalized patientsCOVID-19KDIGO stage 3 acute kidney injuryDialysis-requiring acute kidney injuryStage 3 acute kidney injuryLong-term adverse health outcomesReceptor 1Long-term kidney dysfunctionAvailable blood samplesIdentification of patientsProportional hazards regressionAdverse health outcomesCOVID-19 hospitalization
2019
Association of T Cell–Derived Inflammatory Cytokines With Acute Kidney Injury and Mortality After Cardiac Surgery
Moledina DG, Mansour SG, Jia Y, Obeid W, Thiessen-Philbrook H, Koyner JL, McArthur E, Garg AX, Wilson FP, Shlipak MG, Coca SG, Parikh CR, Consortium T. Association of T Cell–Derived Inflammatory Cytokines With Acute Kidney Injury and Mortality After Cardiac Surgery. Kidney International Reports 2019, 4: 1689-1697. PMID: 31844805, PMCID: PMC6895592, DOI: 10.1016/j.ekir.2019.09.003.Peer-Reviewed Original ResearchAcute kidney injuryIschemia-reperfusion injuryCardiac surgeryKidney injuryIL-13IL-4Higher oddsT cell-derived inflammatory cytokinesPostoperative acute kidney injuryRenal ischemia-reperfusion injuryTh2 biomarkersObservational cohortPreoperative levelsT helperTh2 pathwayClinical outcomesTh2 cytokinesClinical variablesInflammatory cytokinesIndependent associationPlasma biomarkersTh2 cellsSurgeryAnimal modelsMortality
2018
Biomarkers of AKI Progression after Pediatric Cardiac Surgery
Greenberg JH, Zappitelli M, Jia Y, Thiessen-Philbrook HR, de Fontnouvelle CA, Wilson FP, Coca S, Devarajan P, Parikh CR. Biomarkers of AKI Progression after Pediatric Cardiac Surgery. Journal Of The American Society Of Nephrology 2018, 29: 1549-1556. PMID: 29472416, PMCID: PMC5967766, DOI: 10.1681/asn.2017090989.Peer-Reviewed Original ResearchConceptsAKI progressionOptimism-corrected areaIL-8First dayStage 3 AKIUrine L-FABPProspective cohort studyBiomarkers of inflammationPediatric cardiac surgeryConfidence intervalsAKI stagePostoperative AKIKidney injuryCohort studySerum creatinineCardiac surgeryCardiopulmonary bypassTherapeutic trialsUrine biomarkersAdverse outcomesHospitalized childrenPlasma biomarkersClinical careAdditional cohortAKI
2017
Group analysis identifies differentially elevated biomarkers with distinct outcomes for advanced acute kidney injury in cardiac surgery
Lin H, Scherzer R, Philbrook HT, Coca SG, Wilson FP, Garg AX, Shlipak MG, Parikh CR. Group analysis identifies differentially elevated biomarkers with distinct outcomes for advanced acute kidney injury in cardiac surgery. Biomarkers In Medicine 2017, 11: 1091-1102. PMID: 29172665, PMCID: PMC5753615, DOI: 10.2217/bmm-2017-0060.Peer-Reviewed Original ResearchConceptsAdvanced acute kidney injuryAcute kidney injuryKidney injuryCardiac surgeryPatient groupSingle biomarkerIndividual biomarkersPostoperative biomarkersDistinct biomarker patternsNT-proBNPSecondary outcomesIL-10Clinical variablesIL-6Plasma biomarkersCK-MBRisk discriminationAbstractTextH-FABPBiomarkersSignificant differencesSurgeryBiomarker patternsInjuryOutcomes