Featured Publications
Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial
Wilson FP, Martin M, Yamamoto Y, Partridge C, Moreira E, Arora T, Biswas A, Feldman H, Garg AX, Greenberg JH, Hinchcliff M, Latham S, Li F, Lin H, Mansour SG, Moledina DG, Palevsky PM, Parikh CR, Simonov M, Testani J, Ugwuowo U. Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial. The BMJ 2021, 372: m4786. PMID: 33461986, PMCID: PMC8034420, DOI: 10.1136/bmj.m4786.Peer-Reviewed Original ResearchConceptsAcute kidney injuryElectronic health record alertsKidney injuryPrimary outcomeMedical recordsYale New Haven Health SystemCare practicesGlobal Outcomes creatinine criteriaLarge tertiary care centerComposite of progressionDays of randomizationReceipt of dialysisPrespecified secondary outcomesTertiary care centerPatients' medical recordsSmall community hospitalNon-teaching hospitalsElectronic health recordsCreatinine criteriaUsual careSecondary outcomesAdult inpatientsKidney diseaseClinical centersWorse outcomes
2020
A Time-Updated, Parsimonious Model to Predict AKI in Hospitalized Children
Sandokji I, Yamamoto Y, Biswas A, Arora T, Ugwuowo U, Simonov M, Saran I, Martin M, Testani JM, Mansour S, Moledina DG, Greenberg JH, Wilson FP. A Time-Updated, Parsimonious Model to Predict AKI in Hospitalized Children. Journal Of The American Society Of Nephrology 2020, 31: 1348-1357. PMID: 32381598, PMCID: PMC7269342, DOI: 10.1681/asn.2019070745.Peer-Reviewed Original ResearchConceptsExternal validation cohortValidation cohortElectronic health recordsSevere AKIClinical risk stratification toolDevelopment of AKIHealth recordsRisk stratification toolInternal validation cohortLength of stayCharacteristic curveElectronic medical recordsNeonatal AKIInpatient mortalitySecondary outcomesHospital admissionPrimary outcomeHospitalized childrenCreatinine valuesMedical recordsStudy populationAKICohortChildrenPredictive variables
2018
Outcomes Associated With a Strategy of Adjuvant Metolazone or High‐Dose Loop Diuretics in Acute Decompensated Heart Failure: A Propensity Analysis
Brisco‐Bacik M, Maaten J, Houser SR, Vedage NA, Rao V, Ahmad T, Wilson FP, Testani JM. Outcomes Associated With a Strategy of Adjuvant Metolazone or High‐Dose Loop Diuretics in Acute Decompensated Heart Failure: A Propensity Analysis. Journal Of The American Heart Association 2018, 7: e009149. PMID: 30371181, PMCID: PMC6222930, DOI: 10.1161/jaha.118.009149.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedCause of DeathDose-Response Relationship, DrugFemaleFollow-Up StudiesGuideline AdherenceHeart FailureHumansInjections, IntravenousMaleMetolazonePropensity ScoreRetrospective StudiesSodium Chloride Symporter InhibitorsSodium Potassium Chloride Symporter InhibitorsStroke VolumeSurvival RateTreatment OutcomeUnited StatesConceptsHigh-dose loop diureticsAcute decompensated heart failureDecompensated heart failureLoop diureticsRenal functionPropensity adjustmentHeart failureCommon electronic medical recordIntravenous loop diureticsLoop diuretic dosePropensity-adjusted analysisThiazide-type diureticsControl trial dataElectronic medical recordsDiuretic doseDiuretic strategyCause mortalityAdverse eventsBaseline characteristicsSecondary outcomesThiazide diureticsResults PatientsDischarge diagnosisMedical recordsDiuretics
2016
Provider acceptance of an automated electronic alert for acute kidney injury
Oh J, Bia JR, Ubaid-Ullah M, Testani JM, Wilson FP. Provider acceptance of an automated electronic alert for acute kidney injury. Clinical Kidney Journal 2016, 9: 567-571. PMID: 27478598, PMCID: PMC4957729, DOI: 10.1093/ckj/sfw054.Peer-Reviewed Original ResearchAcute kidney injuryElectronic alertsAKI alertsKidney injuryPatient careAKI alert systemElectronic AKI alertsNon-physician providersPercent of respondersHealthcare provider opinionsElectronic medical recordsClinical decision support systemMedical recordsSingle hospitalProviders' opinionsProvider acceptanceTrial durationPaucity of informationPatient-specific informationTrialsSignificant differencesAlert trialsInjuryApprovalCareImpact of e-alert for detection of acute kidney injury on processes of care and outcomes: protocol for a systematic review and meta-analysis
Lachance P, Villeneuve PM, Wilson FP, Selby NM, Featherstone R, Rewa O, Bagshaw SM. Impact of e-alert for detection of acute kidney injury on processes of care and outcomes: protocol for a systematic review and meta-analysis. BMJ Open 2016, 6: e011152. PMID: 27150187, PMCID: PMC4861089, DOI: 10.1136/bmjopen-2016-011152.Peer-Reviewed Original ResearchConceptsAcute kidney injuryE-alertsProcess of careElectronic medical recordsSystematic reviewKidney injuryClinical information systemsEpisode of AKIConsiderable health resourcesPooled effect estimatesHealth resource useHealth service usePatient-centered outcomesGrey literature sourcesResearch ethics approvalMajor morbidityCommon complicationClinical outcomesElectronic alertsPooled analysisMedical recordsPatient outcomesService usePrimary analysisElectronic databases
2014
A trial of in-hospital, electronic alerts for acute kidney injury: Design and rationale
Wilson FP, Reese PP, Shashaty MG, Ellenberg SS, Gitelman Y, Bansal AD, Urbani R, Feldman HI, Fuchs B. A trial of in-hospital, electronic alerts for acute kidney injury: Design and rationale. Clinical Trials 2014, 11: 521-529. PMID: 25023200, PMCID: PMC4156885, DOI: 10.1177/1740774514542619.Peer-Reviewed Original ResearchConceptsAcute kidney injuryKidney injuryElectronic alert systemHospitalized patientsElectronic alertsInformed consentStage 1 acute kidney injuryStage 3 acute kidney injuryAcute kidney injury severityStudy outcomesAcute kidney injury alertsLow-risk interventionBroad inclusion criteriaInpatient mortalitySerum creatinineMedical recordsClinical trialsPatient outcomesInclusion criteriaProvider recognitionEarly deathDichotomous outcomesInjury severityPatientsInjury