2023
IL-6 trans-signaling in a humanized mouse model of scleroderma
Odell I, Agrawal K, Sefik E, Odell A, Caves E, Kirkiles-Smith N, Horsley V, Hinchcliff M, Pober J, Kluger Y, Flavell R. IL-6 trans-signaling in a humanized mouse model of scleroderma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2306965120. PMID: 37669366, PMCID: PMC10500188, DOI: 10.1073/pnas.2306965120.Peer-Reviewed Original ResearchConceptsBone marrow-derived immune cellsIL-6Human hematopoietic stem cellsImmune cellsT cellsScleroderma skinSoluble IL-6 receptorCD8 T cellsHumanized mouse modelPathogenesis of sclerodermaMesenchymal cellsFibroblast-derived IL-6IL-6 receptorIL-6 signalingT cell activationHuman IL-6Human T cellsExpression of collagenFibrosis improvementPansclerotic morpheaHuman endothelial cellsHumanized miceReduced markersSkin graftsHuman CD4
2010
Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival
Hand TW, Cui W, Jung YW, Sefik E, Joshi NS, Chandele A, Liu Y, Kaech SM. Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 16601-16606. PMID: 20823247, PMCID: PMC2944719, DOI: 10.1073/pnas.1003457107.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesCell SurvivalDown-RegulationImmunologic MemoryInterleukin-15Lectins, C-TypeLymphocytic choriomeningitis virusMiceMice, Inbred C57BLMice, Mutant StrainsMice, TransgenicPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReceptors, CytokineReceptors, ImmunologicSignal TransductionSTAT5 Transcription FactorConceptsCD8 T cell survivalT cell survivalPI3K/AktIL-15IL-7IL-15 receptor expressionAntiviral CD8 T cellsBCL2 expressionCD8 T cellsMemory precursor cellsProtective memory cellsAkt activationJAK/STAT5Effector cell deathEffector cellsHomeostatic proliferationReceptor expressionT cellsConstitutive Akt activationCell growth pathwaysConstitutive STAT5 activationViral infectionSTAT5 phosphorylationPrecursor cellsSurvival