2022
ALDH1A1 overexpression in melanoma cells promotes tumor angiogenesis by activating the IL-8/Notch signaling cascade
Ciccone V, Terzuoli E, Ristori E, Filippelli A, Ziche M, Morbidelli L, Donnini S. ALDH1A1 overexpression in melanoma cells promotes tumor angiogenesis by activating the IL-8/Notch signaling cascade. International Journal Of Molecular Medicine 2022, 50: 99. PMID: 35656893, PMCID: PMC9186295, DOI: 10.3892/ijmm.2022.5155.Peer-Reviewed Original ResearchConceptsIL-8Endothelial cellsMelanoma cellsTumor cellsALDH1A1 expressionAngiogenic factorsAngiogenic featuresTumor microenvironmentCancer cellsPoor clinical outcomeHigher microvessel densityNumber of cancersPro-angiogenic phenotypeOverexpression of ALDH1A1ALDH1A1 overexpressionClinical outcomesCo-culture systemMicrovessel densityImmunodeficient miceNF-kBProangiogenic factorsMelanoma cancer cellsTumor angiogenesisMelanoma controlStromal cells
2020
Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells
Ristori E, Cicaloni V, Salvini L, Tinti L, Tinti C, Simons M, Corti F, Donnini S, Ziche M. Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells. Cells 2020, 9: 2506. PMID: 33228083, PMCID: PMC7699411, DOI: 10.3390/cells9112506.Peer-Reviewed Original ResearchMeSH KeywordsActin CytoskeletonAmyloid beta-Protein PrecursorCell ProliferationDown-RegulationEndothelial CellsHumansTransfectionConceptsAmyloid-β precursor proteinCerebral amyloid angiopathyUbiquitous membrane proteinsFocal adhesion stabilityEndothelial cellsMajor cellular targetInteracting proteinActin cytoskeletonProteomic approachMembrane proteinsAlzheimer's diseaseMolecular mechanismsCellular responsesCellular targetsPhysiological roleRole of APPEndothelial cell proliferationPrecursor proteinCell proliferationNormal endothelial functionProteinNeuronal tissueGrowth factorExogenous stimuliExpression
2017
MicroRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos
Kasper DM, Moro A, Ristori E, Narayanan A, Hill-Teran G, Fleming E, Moreno-Mateos M, Vejnar CE, Zhang J, Lee D, Gu M, Gerstein M, Giraldez A, Nicoli S. MicroRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos. Developmental Cell 2017, 40: 552-565.e5. PMID: 28350988, PMCID: PMC5404386, DOI: 10.1016/j.devcel.2017.02.021.Peer-Reviewed Original ResearchConceptsDevelopment of vertebratesEmbryonic blood vesselsVertebrate miRNAsMutant embryosVertebrate embryosHigher organismsMiRNAs functionVascular traitsTrait varianceUniform traitTissue developmentEnvironmental perturbationsSignaling pathwaysPhenotypic variabilityEmbryosPhenotypic heterogeneityOrganismsTraitsProper functioningVascular systemVertebratesMutagenesisMiRNAsMicroRNAsPhenotype
2015
Vascular Mural Cells Promote Noradrenergic Differentiation of Embryonic Sympathetic Neurons
Fortuna V, Pardanaud L, Brunet I, Ola R, Ristori E, Santoro MM, Nicoli S, Eichmann A. Vascular Mural Cells Promote Noradrenergic Differentiation of Embryonic Sympathetic Neurons. Cell Reports 2015, 11: 1786-1796. PMID: 26074079, DOI: 10.1016/j.celrep.2015.05.028.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factor receptorNA differentiationNoradrenergic differentiationMural cell recruitmentDorsal aortaSympathetic neuronsCloche mutantsCell recruitmentZebrafish embryosEmbryonic sympathetic neuronsGrowth factor receptorVascular mural cellsSmooth muscle targetsPostganglionic sympathetic neuronsSympathetic nervous systemMural cellsSympathetic precursorsFactor receptorVascular maturationDifferentiationMuscle toneMuscle targetsNeurovascular interactionsHeart rateNervous system
2014
miRNAs Expression Profile in Zebrafish Developing Vessels
Ristori E, Nicoli S. miRNAs Expression Profile in Zebrafish Developing Vessels. Methods In Molecular Biology 2014, 1214: 129-150. PMID: 25468601, DOI: 10.1007/978-1-4939-1462-3_7.Peer-Reviewed Original ResearchConceptsExpression profilesZebrafish embryonic developmentSmall RNA librariesSmall noncoding RNAsDeep sequencing strategyQuantification of miRNAsPrimary endothelial cellsMiRNAs expression profilesRNA librariesNovel miRNAEmbryonic developmentNoncoding RNAsEndothelial cellsRNA strategySequence variantsSequencing strategyMiRNAsRNACellsMiRNAEarly stagesFACSAngiogenesisVariants