2015
Identification of Medically Actionable Secondary Findings in the 1000 Genomes
Olfson E, Cottrell CE, Davidson NO, Gurnett CA, Heusel JW, Stitziel NO, Chen LS, Hartz S, Nagarajan R, Saccone NL, Bierut LJ. Identification of Medically Actionable Secondary Findings in the 1000 Genomes. PLOS ONE 2015, 10: e0135193. PMID: 26332594, PMCID: PMC4558085, DOI: 10.1371/journal.pone.0135193.Peer-Reviewed Original ResearchMeSH KeywordsDatabases, GeneticGenetic Predisposition to DiseaseGenetic TestingGenetic VariationGenome, HumanGenomicsHumansMutationConceptsSecondary findingsAdditional truncating variantsRelevant secondary findingsCancer predisposition syndromeClinical laboratory specialistsActionable secondary findingsCardiac conditionsAmerican CollegeFamilial hypercholesterolemiaPredisposition syndromeAfrican ancestry groupPathogenic variantsTruncating variantsClinical standardsLiterature reviewActionable conditionsImportant secondary findingActionable findingsDiseaseACMG genesLaboratory specialistsUnderstudied populationAncestry groupsCandidate variantsExpert physicians
2014
Return of individual genetic results in a high-risk sample: enthusiasm and positive behavioral change
Hartz SM, Olfson E, Culverhouse R, Cavazos-Rehg P, Chen LS, DuBois J, Fisher S, Kaphingst K, Kaufman D, Plunk A, Ramnarine S, Solomon S, Saccone NL, Bierut LJ. Return of individual genetic results in a high-risk sample: enthusiasm and positive behavioral change. Genetics In Medicine 2014, 17: 374-379. PMID: 25166427, PMCID: PMC4344933, DOI: 10.1038/gim.2014.110.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyDepressionFollow-Up StudiesGenetic TestingHumansPublic Health SurveillanceRisk FactorsTruth DisclosureConceptsHigh riskPathway GenomicsBaseline measuresAdequate health literacyMultiple risk factorsSymptoms of depressionPercent of participantsHigh baseline measuresAdverse psychological reactionsIncreased riskRisk factorsHigh-risk sampleCessation attemptsGenetic resultsHealth literacyNicotine dependenceUnderserved populationsPositive behavioral changesGenetic riskHealth insuranceDepressionAfrican AmericansLower ratesRiskBehavioral changesSummaries of oral sessions at the XXI World Congress of Psychiatric Genetics, Boston, Massachusetts, 17–21 October 2013
Akpudo H, Aleksic B, Alkelai A, Burton C, Roa T, Chen DT, Cheng MC, Cocchi E, Davis LK, Giori IG, Hubbard LM, Merikangas A, Moily NS, Okewole A, Olfson E, Pappa I, Reitt M, Singh AB, Steinberg J, Strohmaier J, Ting TT, van Hulzen KJ, O’Shea A, DeLisi LE. Summaries of oral sessions at the XXI World Congress of Psychiatric Genetics, Boston, Massachusetts, 17–21 October 2013. Psychiatric Genetics 2014, 24: 125-150. PMID: 24912047, DOI: 10.1097/ypg.0000000000000043.Peer-Reviewed Original Research