Inflammatory Mediators in Uveitis: Differential Induction of Cytokines and Chemokines in Th1- Versus Th2-Mediated Ocular Inflammation
Foxman EF, Zhang M, Hurst SD, Muchamuel T, Shen D, Wawrousek EF, Chan CC, Gery I. Inflammatory Mediators in Uveitis: Differential Induction of Cytokines and Chemokines in Th1- Versus Th2-Mediated Ocular Inflammation. The Journal Of Immunology 2002, 168: 2483-2492. PMID: 11859142, DOI: 10.4049/jimmunol.168.5.2483.Peer-Reviewed Original ResearchConceptsExperimental autoimmune uveoretinitisOcular inflammationAutoimmune uveoretinitisInflammatory mediatorsInflamed eyesChemokine receptorsMouse eyeAg-specific Th1Chemokine mRNA productionInflammation-related moleculesRetinal pigment epithelium cellsPotential therapeutic targetRetinal pigment epitheliumPigment epithelium cellsReal-time RT-PCRMultiplicity of mediatorsTime RT-PCRAdoptive transferInfiltrating leukocytesUpstream cytokinesTh cellsVision lossLaser capture microdissectionTh2 cellsChemokine transcripts