Featured Publications
Lipoprotein Sub-Fractions by Ion-Mobility Analysis and Its Association with Subclinical Coronary Atherosclerosis in High-Risk Individuals
Aneni EC, Osondu CU, De La Cruz J, Martin SS, Blaha MJ, Younus A, Feldman T, Agatston AS, Veledar E, Nasir K. Lipoprotein Sub-Fractions by Ion-Mobility Analysis and Its Association with Subclinical Coronary Atherosclerosis in High-Risk Individuals. Journal Of Atherosclerosis And Thrombosis 2018, 26: 50-63. PMID: 30224606, PMCID: PMC6308270, DOI: 10.5551/jat.40741.Peer-Reviewed Original ResearchConceptsCoronary artery calcificationLipoprotein subfractionsCoronary atherosclerosisRisk of CACLipoprotein particlesLipoprotein subfraction analysisSubclinical coronary atherosclerosisBaptist Health South FloridaLarge LDL particlesHigh-risk personsHigh-risk populationHigh-risk individualsTriglyceride-rich lipoproteinsHigh-risk workersArtery calcificationIDL particlesMetabolic syndromeLipoprotein profileHDL lipoproteinsMean ageLipoprotein subclassesMedium LDLStudy populationRisk individualsVLDL particlesThe relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis
Osondu CU, Vo B, Oni ET, Blaha MJ, Veledar E, Feldman T, Agatston AS, Nasir K, Aneni EC. The relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis. Vascular Medicine 2017, 23: 9-20. PMID: 29243995, DOI: 10.1177/1358863x17725809.Peer-Reviewed Original ResearchConceptsCarotid intima-media thicknessAssociation of EDFlow-mediated dilationSubclinical cardiovascular diseaseCoronary artery calcificationErectile dysfunctionCardiovascular diseaseHigher carotid intima-media thicknessAnkle-brachial indexToe-brachial indexCVD risk assessmentIntima-media thicknessPulse wave velocityArtery calcificationEndothelial dysfunctionCVD mortalityMean ageVascular functionStudy qualityStudy populationAssessment QuestionnaireSystematic reviewDysfunctionPercentage point reductionMultiple databasesBlood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk
Aneni EC, Oni ET, Martin SS, Blaha MJ, Agatston AS, Feldman T, Veledar E, Conçeicao RD, Carvalho JA, Santos RD, Nasir K. Blood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk. Journal Of Hypertension 2015, 33: 1207-1214. PMID: 25693058, DOI: 10.1097/hjh.0000000000000532.Peer-Reviewed Original ResearchConceptsNonobese hypertensive patientsPrevalence of NAFLDMetabolic risk factorsHypertensive patientsNormal BPRisk factorsHigh Blood Pressure classificationNonalcoholic fatty liver diseaseHealthy middle-aged menBlood pressure groupJoint National CommitteeDevelopment of hypertensionFatty liver diseaseYearly physical examinationMiddle-aged menBlood pressure classificationBP controlPrehypertensive patientsCardiometabolic riskCross-sectional relationshipBlood pressureNAFLD severityLiver diseaseNormotensive individualsPhysical examination
2024
Trends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York
Anuforo A, Aneni E, Akintoye E, Anikpezie N, Patel S, Soipe A, Olojakpoke E, Burke D, Latorre J, Khandelwal P, Chaturvedi S, Ovbiagele B, Otite F. Trends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York. Circulation 2024, 149: 1391-1393. PMID: 38648273, DOI: 10.1161/circulationaha.123.066921.Peer-Reviewed Original Research
2023
Demographic Disparities in the Incidence, Clinical Characteristics, and Outcome of Posterior Reversible Encephalopathy Syndrome in the United States
Otite F, Patel S, Anikpezie N, Hoffman H, Beutler T, Akano E, Aneni E, Lamikanra O, Osondu C, Wee C, Burke D, Albright K, Latorre J, Mejico L, Khandelwal P, Chaturvedi S. Demographic Disparities in the Incidence, Clinical Characteristics, and Outcome of Posterior Reversible Encephalopathy Syndrome in the United States. Neurology 2023, 101: e1554-e1559. PMID: 37487751, PMCID: PMC10585693, DOI: 10.1212/wnl.0000000000207604.Peer-Reviewed Original ResearchConceptsPosterior reversible encephalopathy syndromeNational Readmission DatabaseReversible encephalopathy syndromeEncephalopathy syndromeFemale patientsHispanic patientsMale patientsSex-standardized incidenceRetrospective cohort studyRace-specific incidenceSimilar demographic distributionState Inpatient DatabasesNon-Hispanic whitesIncident hospitalizationClinical characteristicsCohort studyFirst hospitalizationBlack patientsInpatient DatabasePatientsNew casesIncidenceStudy periodDemographic disparitiesHospitalizationAge- and Sex-Specific Trends in Medical Complications After Acute Ischemic Stroke in the United States
Ahmed R, Mhina C, Philip K, Patel S, Aneni E, Osondu C, Lamikanra O, Akano E, Anikpezie N, Albright K, Latorre J, Chaturvedi S, Otite F. Age- and Sex-Specific Trends in Medical Complications After Acute Ischemic Stroke in the United States. Neurology 2023, 100: e1282-e1295. PMID: 36599695, PMCID: PMC10033158, DOI: 10.1212/wnl.0000000000206749.Peer-Reviewed Original ResearchConceptsSex-specific prevalenceAIS admissionsNoninfectious complicationsAcute ischemic stroke hospitalizationsSerial cross-sectional studyPrevalence of UTIRisk of UTIAcute ischemic strokeNational Inpatient SampleNIH Stroke ScaleIschemic stroke hospitalizationsCross-sectional studyAge/sexSex-specific trendsHospital mortalityInfectious complicationsMultivariable adjustmentStroke ScaleCommon complicationIschemic strokeMechanical thrombectomyMedical complicationsComplication riskPE prevalenceStroke hospitalizations
2022
Trends in age and sex-specific prevalence of cancer and cancer subtypes in acute ischemic stroke from 2007-2019
Otite F, Somani S, Aneni E, Akano E, Patel S, Anikpezie N, Lamikanra O, Masoud H, Latorre J, Chaturvedi S, Mehndiratta P. Trends in age and sex-specific prevalence of cancer and cancer subtypes in acute ischemic stroke from 2007-2019. Journal Of Stroke And Cerebrovascular Diseases 2022, 31: 106818. PMID: 36323171, DOI: 10.1016/j.jstrokecerebrovasdis.2022.106818.Peer-Reviewed Original ResearchConceptsSex-specific prevalenceCancer prevalenceGenitourinary cancersAIS admissionsActive cancerGastrointestinal cancerMetastatic cancerSolid cancersPrimary central nervous system cancerRetrospective serial cross-sectional studyAcute ischemic stroke hospitalizationsSerial cross-sectional studyCentral nervous system cancerLung cancer prevalenceAcute ischemic strokeNational Inpatient SampleIschemic stroke hospitalizationsHead/neckNervous system cancersCommon solid cancersCross-sectional studyPrevalence of cancerCancer admissionsIschemic strokeStroke hospitalizations
2019
Gaps in provider lifestyle counseling and its adherence among obese adults with prediabetes and diabetes in the United States
Valero-Elizondo J, Aneni EC, Osondu CU, Grandhi GR, Virani SS, Nasir K. Gaps in provider lifestyle counseling and its adherence among obese adults with prediabetes and diabetes in the United States. Preventive Medicine 2019, 129: 105815. PMID: 31454663, DOI: 10.1016/j.ypmed.2019.105815.Peer-Reviewed Original ResearchConceptsLifestyle counselingObese adultsHealthcare providersManagement of obesityPrevalence of diabetesWeight loss programUS adult populationLevels of obesityLifestyle modificationDiabetes statusObese patientsSevere obesityLoss programMild obesityCardiovascular diseasePhysical activityObesity epidemicObesityDiabetesMetabolic diseasesAdult populationHealthy lifestyleCounselingPatientsAdults
2015
Prevalence of Ideal Cardiovascular Health Among Adults in the United States
Younus A, Aneni EC, Spatz ES, Osondu CU, Shaharyar S, Roberson L, Ali SS, Ogunmoroti O, Ahmad R, Post J, Feldman T, Maziak W, Agatston AS, Veledar E, Nasir K. Prevalence of Ideal Cardiovascular Health Among Adults in the United States. Journal Of The American College Of Cardiology 2015, 66: 1633-1634. PMID: 26429090, DOI: 10.1016/j.jacc.2015.06.1348.Peer-Reviewed Original ResearchObesity Modifies the Effect of Fitness on Heart Rate Indices during Exercise Stress Testing in Asymptomatic Individuals
Aneni EC, Oni ET, Osondu CU, Martin SS, Blaha MJ, Veledar E, Agatston AS, Feldman T, Carvalho JA, Conceição RD, Santos RD, Nasir K. Obesity Modifies the Effect of Fitness on Heart Rate Indices during Exercise Stress Testing in Asymptomatic Individuals. Cardiology 2015, 132: 242-248. PMID: 26329389, DOI: 10.1159/000435907.Peer-Reviewed Original ResearchConceptsHeart rateHR recoveryDifferent body mass index (BMI) categoriesBody mass index categoriesExercise stress testExercise stress testingExercise heart ratePeak heart rateHeart rate indexCross-sectional analysisEffects of fitnessObesity modifiesAsymptomatic cohortPeak exerciseBMI categoriesObese subjectsAsymptomatic individualsMetabolic equivalentsIndex categoriesMultivariate analysisAerobic fitnessBrazilian subjectsWeight lossStatistical significanceStress testingElevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging
Malik R, Aneni EC, Shahrayar S, Freitas WM, Ali SS, Veledar E, Latif MA, Aziz M, Ahmed R, Khan SA, Joseph J, Feiz H, Sposito A, Nasir K. Elevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging. Aging Clinical And Experimental Research 2015, 28: 359-362. PMID: 26084248, DOI: 10.1007/s40520-015-0395-3.Peer-Reviewed Original ResearchConceptsSerum uric acidElevated hs-CRPCoronary artery calcificationHs-CRPSUA tertilesCardiovascular diseaseCoronary atherosclerosisHealthy octogenariansArtery calcificationVascular inflammationAssociation of SUATertiles of SUAElevated serum uric acidSensitive C-reactive proteinMedian hs-CRPClinical cardiovascular diseaseHigher SUA levelsC-reactive proteinSubclinical cardiovascular diseaseUric acidCAC burdenCAC presenceSUA levelsOverall prevalenceElderly population
2014
Beyond BMI: The “Metabolically healthy obese” phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review
Roberson LL, Aneni EC, Maziak W, Agatston A, Feldman T, Rouseff M, Tran T, Blaha MJ, Santos RD, Sposito A, Al-Mallah MH, Blankstein R, Budoff MJ, Nasir K. Beyond BMI: The “Metabolically healthy obese” phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review. BMC Public Health 2014, 14: 14. PMID: 24400816, PMCID: PMC3890499, DOI: 10.1186/1471-2458-14-14.Peer-Reviewed Original ResearchConceptsIncident cardiovascular diseaseCoronary artery calciumSubclinical cardiovascular diseaseCause mortalityCardiovascular diseaseCVD mortalityCommon carotid artery intima-media thicknessAdult Treatment Panel III definitionCarotid artery intima-media thicknessArtery intima-media thicknessDefinition of MHOHealthy obese populationSubclinical CVD markersTypical metabolic disordersMetabolic syndrome componentsIntima-media thicknessRisk cardiovascular diseaseWeb of ScienceCVD markersHealthy obeseMHO groupArtery calciumCVD riskSyndrome componentsMetabolic syndrome