Featured Publications
The relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis
Osondu CU, Vo B, Oni ET, Blaha MJ, Veledar E, Feldman T, Agatston AS, Nasir K, Aneni EC. The relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis. Vascular Medicine 2017, 23: 9-20. PMID: 29243995, DOI: 10.1177/1358863x17725809.Peer-Reviewed Original ResearchConceptsCarotid intima-media thicknessAssociation of EDFlow-mediated dilationSubclinical cardiovascular diseaseCoronary artery calcificationErectile dysfunctionCardiovascular diseaseHigher carotid intima-media thicknessAnkle-brachial indexToe-brachial indexCVD risk assessmentIntima-media thicknessPulse wave velocityArtery calcificationEndothelial dysfunctionCVD mortalityMean ageVascular functionStudy qualityStudy populationAssessment QuestionnaireSystematic reviewDysfunctionPercentage point reductionMultiple databasesEstimates of Mortality Benefit From Ideal Cardiovascular Health Metrics: A Dose Response Meta‐Analysis
Aneni EC, Crippa A, Osondu CU, Valero‐Elizondo J, Younus A, Nasir K, Veledar E. Estimates of Mortality Benefit From Ideal Cardiovascular Health Metrics: A Dose Response Meta‐Analysis. Journal Of The American Heart Association 2017, 6: e006904. PMID: 29269350, PMCID: PMC5779012, DOI: 10.1161/jaha.117.006904.Peer-Reviewed Original ResearchConceptsIdeal cardiovascular healthIdeal CVH metricsPooled hazard ratioCVH metricsCardiovascular healthMortality benefitHazard ratioCardiovascular disease-related mortalityDose–response meta analysisStrong public health messageIdeal cardiovascular health metricsSubstantial mortality benefitCardiovascular health metricsCardiovascular disease mortalityLinear dose-response relationshipDisease-related mortalityPublic health messagesHazard ratio estimatesDose-response relationshipUnit increaseWeb of ScienceCause mortalityInternet literature searchDisease mortalityCardiovascular diseaseBlood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk
Aneni EC, Oni ET, Martin SS, Blaha MJ, Agatston AS, Feldman T, Veledar E, Conçeicao RD, Carvalho JA, Santos RD, Nasir K. Blood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk. Journal Of Hypertension 2015, 33: 1207-1214. PMID: 25693058, DOI: 10.1097/hjh.0000000000000532.Peer-Reviewed Original ResearchConceptsNonobese hypertensive patientsPrevalence of NAFLDMetabolic risk factorsHypertensive patientsNormal BPRisk factorsHigh Blood Pressure classificationNonalcoholic fatty liver diseaseHealthy middle-aged menBlood pressure groupJoint National CommitteeDevelopment of hypertensionFatty liver diseaseYearly physical examinationMiddle-aged menBlood pressure classificationBP controlPrehypertensive patientsCardiometabolic riskCross-sectional relationshipBlood pressureNAFLD severityLiver diseaseNormotensive individualsPhysical examination
2023
Age- and Sex-Specific Trends in Medical Complications After Acute Ischemic Stroke in the United States
Ahmed R, Mhina C, Philip K, Patel S, Aneni E, Osondu C, Lamikanra O, Akano E, Anikpezie N, Albright K, Latorre J, Chaturvedi S, Otite F. Age- and Sex-Specific Trends in Medical Complications After Acute Ischemic Stroke in the United States. Neurology 2023, 100: e1282-e1295. PMID: 36599695, PMCID: PMC10033158, DOI: 10.1212/wnl.0000000000206749.Peer-Reviewed Original ResearchConceptsSex-specific prevalenceAIS admissionsNoninfectious complicationsAcute ischemic stroke hospitalizationsSerial cross-sectional studyPrevalence of UTIRisk of UTIAcute ischemic strokeNational Inpatient SampleNIH Stroke ScaleIschemic stroke hospitalizationsCross-sectional studyAge/sexSex-specific trendsHospital mortalityInfectious complicationsMultivariable adjustmentStroke ScaleCommon complicationIschemic strokeMechanical thrombectomyMedical complicationsComplication riskPE prevalenceStroke hospitalizations
2022
Cardiometabolic disorders, inflammation and the incidence of non-alcoholic fatty liver disease: A longitudinal study comparing lean and non-lean individuals
Aneni E, Saeed G, Bittencourt M, Cainzos-Achirica M, Osondu C, Budoff M, Parise E, Santos R, Nasir K. Cardiometabolic disorders, inflammation and the incidence of non-alcoholic fatty liver disease: A longitudinal study comparing lean and non-lean individuals. PLOS ONE 2022, 17: e0266505. PMID: 35385529, PMCID: PMC8985996, DOI: 10.1371/journal.pone.0266505.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseRisk of NAFLDElevated blood glucoseElevated blood pressureFatty liver diseaseBlood glucoseLean individualsBlood pressureCardiometabolic disordersPhysical inactivityWaist circumferenceLiver diseaseDevelopment of NAFLDHigh-sensitivity C-reactive proteinCardiovascular disease risk stratificationSensitivity C-reactive proteinCardiometabolic risk factorsAlcohol Use Disorders Identification TestC-reactive proteinMain exposure variableDisease risk stratificationHospital Israelita Albert EinsteinDisorders Identification TestAppropriate preventive measuresAtherogenic dyslipidemia
2016
A Systematic Review of the Prevalence and Outcomes of Ideal Cardiovascular Health in US and Non-US Populations
Younus A, Aneni EC, Spatz ES, Osondu CU, Roberson L, Ogunmoroti O, Malik R, Ali SS, Aziz M, Feldman T, Virani SS, Maziak W, Agatston AS, Veledar E, Nasir K. A Systematic Review of the Prevalence and Outcomes of Ideal Cardiovascular Health in US and Non-US Populations. Mayo Clinic Proceedings 2016, 91: 649-670. PMID: 27040086, DOI: 10.1016/j.mayocp.2016.01.019.Peer-Reviewed Original ResearchConceptsIdeal CVH metricsNon-CVD outcomesIdeal cardiovascular health metricsCVH metricsIdeal cardiovascular healthCardiovascular healthLow prevalenceAmerican Heart Association ideal cardiovascular health (CVH) metricsSystematic reviewMore ideal CVH metricsIncident cardiovascular eventsCardiovascular health metricsPopulation-based studyNon-US populationsCochrane RegisterCardiovascular eventsControlled TrialsUS cohortInverse associationCardiovascular diseaseCINAHL databasesMortality riskMortality studyCognitive impairmentUS population
2015
Obesity Modifies the Effect of Fitness on Heart Rate Indices during Exercise Stress Testing in Asymptomatic Individuals
Aneni EC, Oni ET, Osondu CU, Martin SS, Blaha MJ, Veledar E, Agatston AS, Feldman T, Carvalho JA, Conceição RD, Santos RD, Nasir K. Obesity Modifies the Effect of Fitness on Heart Rate Indices during Exercise Stress Testing in Asymptomatic Individuals. Cardiology 2015, 132: 242-248. PMID: 26329389, DOI: 10.1159/000435907.Peer-Reviewed Original ResearchConceptsHeart rateHR recoveryDifferent body mass index (BMI) categoriesBody mass index categoriesExercise stress testExercise stress testingExercise heart ratePeak heart rateHeart rate indexCross-sectional analysisEffects of fitnessObesity modifiesAsymptomatic cohortPeak exerciseBMI categoriesObese subjectsAsymptomatic individualsMetabolic equivalentsIndex categoriesMultivariate analysisAerobic fitnessBrazilian subjectsWeight lossStatistical significanceStress testingElevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging
Malik R, Aneni EC, Shahrayar S, Freitas WM, Ali SS, Veledar E, Latif MA, Aziz M, Ahmed R, Khan SA, Joseph J, Feiz H, Sposito A, Nasir K. Elevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging. Aging Clinical And Experimental Research 2015, 28: 359-362. PMID: 26084248, DOI: 10.1007/s40520-015-0395-3.Peer-Reviewed Original ResearchConceptsSerum uric acidElevated hs-CRPCoronary artery calcificationHs-CRPSUA tertilesCardiovascular diseaseCoronary atherosclerosisHealthy octogenariansArtery calcificationVascular inflammationAssociation of SUATertiles of SUAElevated serum uric acidSensitive C-reactive proteinMedian hs-CRPClinical cardiovascular diseaseHigher SUA levelsC-reactive proteinSubclinical cardiovascular diseaseUric acidCAC burdenCAC presenceSUA levelsOverall prevalenceElderly population
2014
Beyond BMI: The “Metabolically healthy obese” phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review
Roberson LL, Aneni EC, Maziak W, Agatston A, Feldman T, Rouseff M, Tran T, Blaha MJ, Santos RD, Sposito A, Al-Mallah MH, Blankstein R, Budoff MJ, Nasir K. Beyond BMI: The “Metabolically healthy obese” phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review. BMC Public Health 2014, 14: 14. PMID: 24400816, PMCID: PMC3890499, DOI: 10.1186/1471-2458-14-14.Peer-Reviewed Original ResearchConceptsIncident cardiovascular diseaseCoronary artery calciumSubclinical cardiovascular diseaseCause mortalityCardiovascular diseaseCVD mortalityCommon carotid artery intima-media thicknessAdult Treatment Panel III definitionCarotid artery intima-media thicknessArtery intima-media thicknessDefinition of MHOHealthy obese populationSubclinical CVD markersTypical metabolic disordersMetabolic syndrome componentsIntima-media thicknessRisk cardiovascular diseaseWeb of ScienceCVD markersHealthy obeseMHO groupArtery calciumCVD riskSyndrome componentsMetabolic syndrome