2024
Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety
Kitt E, Zacharek S, Odriozola P, Nardini C, Hommel G, Martino A, Anderson T, Spencer H, Broussard A, Dean J, Marin C, Silverman W, Lebowitz E, Gee D. Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety. Journal Of Affective Disorders 2024, 351: 818-826. PMID: 38290579, PMCID: PMC10981528, DOI: 10.1016/j.jad.2024.01.204.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxietyAnxiety DisordersBrain MappingChildHumansMagnetic Resonance ImagingPrefrontal CortexConceptsReactivity to threatMeasures of avoidanceVentral anterior insulaClinician-based measuresNeural reactivityPediatric anxietyAnxiety disordersBehavioral avoidanceFunctional magnetic resonance imaging taskAmygdala functional connectivityVentromedial prefrontal cortexTreatment-seeking sampleAvoidance of threatClinically significant constructsAssociated with tasksGeneralizability of findingsPrefrontal cortexAnterior insulaNeural findingsLaboratory tasksFunctional connectivityAnxietyAmygdalaAvoidanceSignificant constructs
2022
Experimental evidence for a child‐to‐adolescent switch in human amygdala‐prefrontal cortex communication: A cross‐sectional pilot study
Gee DG, Hanson C, Caglar LR, Fareri DS, Gabard‐Durnam L, Mills‐Finnerty C, Goff B, Caldera CJ, Lumian DS, Flannery J, Hanson SJ, Tottenham N. Experimental evidence for a child‐to‐adolescent switch in human amygdala‐prefrontal cortex communication: A cross‐sectional pilot study. Developmental Science 2022, 25: e13238. PMID: 35080089, PMCID: PMC9232876, DOI: 10.1111/desc.13238.Peer-Reviewed Original ResearchConceptsCross-sectional pilot studyAge-related switchAmygdala reactivityPresent cross-sectional pilot studyPilot studyAnterior cingulate cortex activationDorsal anterior cingulate cortex (dACC) activationAmygdala connectivityCortex activationPrefrontal cortexDACC activationAmygdalaPrefrontal functionChildhoodPrefrontal engagementEmotional behaviorChildhood experiencesAdolescenceVentromedial PFCDACCOpposite effectBayesian network analysisActivationVmPFCReverse information flow
2020
Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders – A preliminary study
Harrewijn A, Kitt ER, Abend R, Matsumoto C, Odriozola P, Winkler AM, Leibenluft E, Pine DS, Gee DG. Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders – A preliminary study. Behavioural Brain Research 2020, 399: 112994. PMID: 33160010, PMCID: PMC7855938, DOI: 10.1016/j.bbr.2020.112994.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPediatric anxiety disordersAnxiety disordersNeural correlatesHigher skin conductance responsesDorsal anterior cingulate cortexRight ventromedial prefrontal cortexVentromedial prefrontal cortexSkin conductance responsesReduced fear responsesAnterior cingulate cortexCurrent pilot studyThreat learningAnxious youthSafety cuesThreat cuesFear acquisitionVmPFC activityAversive soundSafety compoundCBT responseFear responsesNovel cuesConductance responsesPrefrontal cortex
2018
Atypical frontoamygdala functional connectivity in youth with autism
Odriozola P, Dajani DR, Burrows CA, Gabard-Durnam LJ, Goodman E, Baez AC, Tottenham N, Uddin LQ, Gee DG. Atypical frontoamygdala functional connectivity in youth with autism. Developmental Cognitive Neuroscience 2018, 37: 100603. PMID: 30581125, PMCID: PMC6570504, DOI: 10.1016/j.dcn.2018.12.001.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAutism Spectrum DisorderChildCross-Sectional StudiesHumansMagnetic Resonance ImagingMalePrefrontal CortexConceptsAutism spectrum disorderRostral anterior cingulate cortexFunctional connectivityTD individualsDifferent age-related patternsResting-state functional connectivityOverall group differencesBroad developmental rangeAnterior cingulate cortexSocioemotional functioningSocioemotional impairmentsSpectrum disorderCross-sectional sampleAge-related changesRight basolateral amygdalaCingulate cortexAge-related patternsGroup differencesDevelopmental rangeFrontoamygdala circuitryBasolateral amygdalaAmygdalaIndividualsPrior workImpairmentNeurocognitive Development of Motivated Behavior: Dynamic Changes across Childhood and Adolescence
Gee DG, Bath KG, Johnson CM, Meyer HC, Murty VP, van den Bos W, Hartley CA. Neurocognitive Development of Motivated Behavior: Dynamic Changes across Childhood and Adolescence. Journal Of Neuroscience 2018, 38: 9433-9445. PMID: 30381435, PMCID: PMC6209847, DOI: 10.1523/jneurosci.1674-18.2018.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdolescentChildChild DevelopmentCognitionHumansMotivationNerve NetPrefrontal CortexStress, PsychologicalConceptsMotivated behaviorProcessing of threatReward-motivated behaviorsNeural circuitsEarly life stressCognitive processesCourse of developmentDevelopmental trajectoriesExperiential factorsNeurocognitive developmentAdaptive behaviorRecent methodological innovationsDevelopmental changesDevelopmental onsetRecent researchPsychiatric disordersAdulthoodMethodological innovationsAdolescenceNeurocircuitryRewardBehaviorResearchChildhoodProcessing
2016
Stimulus-Elicited Connectivity Influences Resting-State Connectivity Years Later in Human Development: A Prospective Study
Gabard-Durnam LJ, Gee DG, Goff B, Flannery J, Telzer E, Humphreys KL, Lumian DS, Fareri DS, Caldera C, Tottenham N. Stimulus-Elicited Connectivity Influences Resting-State Connectivity Years Later in Human Development: A Prospective Study. Journal Of Neuroscience 2016, 36: 4771-4784. PMID: 27122035, PMCID: PMC4846673, DOI: 10.1523/jneurosci.0598-16.2016.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexFunctional connectivityAmygdala-medial prefrontal cortex circuitInferior frontal gyrusResting-state functional networksFunctional architectureResting-state connectivityAmygdala functional connectivityFunctional network architecturePrefrontal cortex circuitAmygdala-mPFC circuitResting-state networksFunctional connectionsEmotional stimuliCourse of developmentFrontal gyrusAge-related changesPrefrontal cortexMotivate future investigationsCortex circuitPredictive associationsSensitive periodFunctional networksDevelopmental periodBrain function
2014
Maternal Buffering of Human Amygdala-Prefrontal Circuitry During Childhood but Not During Adolescence
Gee DG, Gabard-Durnam L, Telzer EH, Humphreys KL, Goff B, Shapiro M, Flannery J, Lumian DS, Fareri DS, Caldera C, Tottenham N. Maternal Buffering of Human Amygdala-Prefrontal Circuitry During Childhood but Not During Adolescence. Psychological Science 2014, 25: 2067-2078. PMID: 25280904, PMCID: PMC4377225, DOI: 10.1177/0956797614550878.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffectAge FactorsAmygdalaBrain MappingChildChild, PreschoolFemaleHumansMagnetic Resonance ImagingMaleMothersPrefrontal CortexConceptsAmygdala-prefrontal circuitryMaternal bufferingMaternal stimuliAmygdala-prefrontal connectivityMature connectivityAmygdala reactivityPotential mechanismsMaternal modulationChildhoodMother-child relationshipNeural mechanismsSensitive periodChildrenCaregiversMaternal influenceRegulatory influenceAdolescenceStimuliBehavioral regulationNeurocircuitryCircuitry
2013
Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation
Gee DG, Gabard-Durnam LJ, Flannery J, Goff B, Humphreys KL, Telzer EH, Hare TA, Bookheimer SY, Tottenham N. Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 15638-15643. PMID: 24019460, PMCID: PMC3785723, DOI: 10.1073/pnas.1307893110.Peer-Reviewed Original ResearchConceptsMaternal deprivationAmygdala-mPFC connectivityEarly adversityEarly maternal deprivationAmygdala-prefrontal connectivityMature connectivityRodent modelsReduced anxietyAdolescent phenotypeHormone cortisolEarly developmental emergenceStress-induced modificationsDeprivationComparison childrenConnectivity patternsChildrenDevelopmental emergenceAnxietyPhenotypeInstitutionalized youthAmygdalaAdversityCortisolOntogenetic adaptationA Developmental Shift from Positive to Negative Connectivity in Human Amygdala–Prefrontal Circuitry
Gee DG, Humphreys KL, Flannery J, Goff B, Telzer EH, Shapiro M, Hare TA, Bookheimer SY, Tottenham N. A Developmental Shift from Positive to Negative Connectivity in Human Amygdala–Prefrontal Circuitry. Journal Of Neuroscience 2013, 33: 4584-4593. PMID: 23467374, PMCID: PMC3670947, DOI: 10.1523/jneurosci.3446-12.2013.Peer-Reviewed Original ResearchConceptsAmygdala-prefrontal circuitryFunctional connectivityNegative connectivityAmygdala reactivityRecent human imagingParticipants 10 yearsTask-based functional magnetic resonance imagingNegative functional connectivityFunctional magnetic resonance imagingMagnetic resonance imagingAmygdala-prefrontal connectivityAmygdala-cortical connectivityAnxiety-related disordersFrontoamygdala circuitryAnimal studiesReciprocal connectionsResonance imagingTracing studyPositive connectivityAdolescent periodEarly childhoodNeurobiological basisEmotional behaviorPresent studyDevelopmental changes
2011
Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: A preliminary study
Gee DG, Karlsgodt KH, van Erp TG, Bearden CE, Lieberman MD, Belger A, Perkins DO, Olvet DM, Cornblatt BA, Constable T, Woods SW, Addington J, Cadenhead KS, McGlashan TH, Seidman LJ, Tsuang MT, Walker EF, Cannon TD, Consortium O. Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: A preliminary study. Schizophrenia Research 2011, 134: 1-9. PMID: 22056201, PMCID: PMC3245800, DOI: 10.1016/j.schres.2011.10.005.Peer-Reviewed Original ResearchConceptsClinical high riskFunctional connectivityPrefrontal cortexCHR adolescentsHigh riskAmygdala-prefrontal functional connectivityAmygdala-prefrontal circuitryCross-sectional analysisPsychophysiological interaction analysisVLPFC activationIllness onsetAge-related trajectoriesRisk syndromeVentrolateral prefrontal cortexInteraction of ageOvert psychosisAge-related variationsPsychosisAmygdala reactivityBrain connectivityFunctional activationAmygdalaCortexLater deficitsFMRI task