2024
Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety
Kitt E, Zacharek S, Odriozola P, Nardini C, Hommel G, Martino A, Anderson T, Spencer H, Broussard A, Dean J, Marin C, Silverman W, Lebowitz E, Gee D. Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety. Journal Of Affective Disorders 2024, 351: 818-826. PMID: 38290579, PMCID: PMC10981528, DOI: 10.1016/j.jad.2024.01.204.Peer-Reviewed Original ResearchConceptsReactivity to threatMeasures of avoidanceVentral anterior insulaClinician-based measuresNeural reactivityPediatric anxietyAnxiety disordersBehavioral avoidanceFunctional magnetic resonance imaging taskAmygdala functional connectivityVentromedial prefrontal cortexTreatment-seeking sampleAvoidance of threatClinically significant constructsAssociated with tasksGeneralizability of findingsPrefrontal cortexAnterior insulaNeural findingsLaboratory tasksFunctional connectivityAnxietyAmygdalaAvoidanceSignificant constructs
2022
Family accommodation in pediatric anxiety: Relations with avoidance and self-efficacy
Kitt ER, Lewis KM, Galbraith J, Abend R, Smith AR, Lebowitz ER, Pine DS, Gee DG. Family accommodation in pediatric anxiety: Relations with avoidance and self-efficacy. Behaviour Research And Therapy 2022, 154: 104107. PMID: 35613517, PMCID: PMC9271364, DOI: 10.1016/j.brat.2022.104107.Peer-Reviewed Original ResearchConceptsFamily accommodationPediatric anxietyAnxiety disordersNon-anxious controlsClinician ratingsPediatric anxiety disordersReal-world behaviorImportant preliminary insightsBody of researchLaboratory tasksMediation modelGreater avoidanceAge 8AnxietyDistinct measuresUntested relationsFuture researchYouthRobust associationAvoidanceBehavioral factorsRatingsPreliminary insightsEarly identificationDisordersTraining the Next Generation of Clinical Psychological Scientists: A Data-Driven Call to Action
Gee DG, DeYoung KA, McLaughlin KA, Tillman RM, Barch DM, Forbes EE, Krueger RF, Strauman TJ, Weierich MR, Shackman AJ. Training the Next Generation of Clinical Psychological Scientists: A Data-Driven Call to Action. Annual Review Of Clinical Psychology 2022, 18: 43-70. PMID: 35216523, PMCID: PMC9086080, DOI: 10.1146/annurev-clinpsy-081219-092500.Peer-Reviewed Original ResearchConceptsClinical psychologyClinical psychological scientistsPsychological scientistsMental health conditionsCurrent training practicesMental healthSubstance useIntervention strategiesPsychologyTraining practicesClinical scientistsMental disordersGlobal public healthCentral goalImmense burdenSpecific recommendationsAnxietyPersonalityHealth conditionsMoodScientific rigorPublic healthPsychosisHealthBurden
2021
Leveraging big data to map neurodevelopmental trajectories in pediatric anxiety
Zacharek SJ, Kribakaran S, Kitt ER, Gee DG. Leveraging big data to map neurodevelopmental trajectories in pediatric anxiety. Developmental Cognitive Neuroscience 2021, 50: 100974. PMID: 34147988, PMCID: PMC8225701, DOI: 10.1016/j.dcn.2021.100974.Peer-Reviewed Original ResearchConceptsPediatric anxietyNeurodevelopmental trajectoriesAnxiety disordersNormative brain developmentPrevalent psychiatric conditionAge-related differencesAnxious youthSafety learningUnderstanding of neurodevelopmentAnxietyInconsistent findingsBrain structuresLongitudinal studyNeural structuresPsychiatric conditionsNovel treatment targetsMarker of riskBrain developmentTreatment targetsEarly risk identificationYouthFuture directionsDisordersAdolescenceNeurobiologyEmotion and Emotion Preferences in Daily Life: The Role of Anxiety
Vanderlind WM, Everaert J, Caballero C, Cohodes EM, Gee DG. Emotion and Emotion Preferences in Daily Life: The Role of Anxiety. Clinical Psychological Science 2021, 10: 109-126. PMID: 35174008, PMCID: PMC8845725, DOI: 10.1177/21677026211009500.Peer-Reviewed Original ResearchEmotion preferencesEcological momentary assessmentTrait anxietyLow-anxiety counterpartsSymptom severityAnxiety symptom severityMeasures of anxietyRole of anxietyState emotionsEmotion dysfunctionIndividual differencesSubsequent anxietySevere anxiety symptomsState anxietyAnxiety symptomsMomentary assessmentEmotionsAnxietyCurrent findingsNovel treatment targetsGreater preferenceCurrent studyTreatment targetsDifferent associationsDaily life
2020
Developmental Differences in Neural Responding to Threat and Safety: Implications for Treating Youths With Anxiety
Gee DG, Kribakaran S. Developmental Differences in Neural Responding to Threat and Safety: Implications for Treating Youths With Anxiety. American Journal Of Psychiatry 2020, 177: 378-380. PMID: 32354263, DOI: 10.1176/appi.ajp.2020.20020225.Peer-Reviewed Original Research
2019
Novel insights from actigraphy: Anxiety is associated with sleep quantity but not quality during childhood
Cohodes EM, Abusch A, Odriozola P, Gee DG. Novel insights from actigraphy: Anxiety is associated with sleep quantity but not quality during childhood. Clinical Child Psychology And Psychiatry 2019, 25: 189-199. PMID: 30696260, PMCID: PMC6667310, DOI: 10.1177/1359104518822685.Peer-Reviewed Original ResearchConceptsSleep quantitySleep-related interventionsSleep functionPredictors of anxietyPediatric clinical samplesAge-related changesHigh anxietyAnxietyPediatric samplesPrevious researchSleep dysfunctionClinical samplesChildhoodFunction changesAdolescenceAdolescentsActigraphyPresent studyYouthQuantitative measuresCorrelatesAssociationSleepChildrenIntervention
2018
Implications of the Research Domain Criteria project for childhood anxiety and its disorders
Lebowitz ER, Gee DG, Pine DS, Silverman WK. Implications of the Research Domain Criteria project for childhood anxiety and its disorders. Clinical Psychology Review 2018, 64: 99-109. PMID: 29526524, PMCID: PMC6668617, DOI: 10.1016/j.cpr.2018.01.005.Peer-Reviewed Original ResearchConceptsChildhood anxiety disordersChildhood anxietyResearch Domain Criteria projectAnxiety disordersSocial processesMental Health's Research Domain Criteria projectNegative Valence Systems domainFronto-amygdala circuitryThreat learningPsychiatric disordersNegative valencePediatric anxietyChildren's fearsDevelopmental psychopathologyPrevalent psychiatric disordersParticular social processesAnxietyAttachment processRDoCResearch linksFearYouthTranslational approachDisordersInterdisciplinary approach
2017
The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development
Meyer HC, Lee FS, Gee DG. The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development. Neuropsychopharmacology 2017, 43: 21-33. PMID: 28685756, PMCID: PMC5719094, DOI: 10.1038/npp.2017.143.Peer-Reviewed Original ResearchConceptsAnxiety-related behaviorDevelopmental trajectoriesAdolescent brain developmentRegulation of fearConsequences of stressGenetic variationBrain developmentBehavioral processingECB systemPrefrontal cortexEmotional behaviorHuman genetic variationCorticolimbic structuresStress responsivityBrain regionsAdolescenceRegulation of stressNeural circuitsEndocannabinoid systemAnxietyEnvironmental perturbationsRole of eCBFunctional implicationsCentral roleLife span
2013
Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation
Gee DG, Gabard-Durnam LJ, Flannery J, Goff B, Humphreys KL, Telzer EH, Hare TA, Bookheimer SY, Tottenham N. Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 15638-15643. PMID: 24019460, PMCID: PMC3785723, DOI: 10.1073/pnas.1307893110.Peer-Reviewed Original ResearchConceptsMaternal deprivationAmygdala-mPFC connectivityEarly adversityEarly maternal deprivationAmygdala-prefrontal connectivityMature connectivityRodent modelsReduced anxietyAdolescent phenotypeHormone cortisolEarly developmental emergenceStress-induced modificationsDeprivationComparison childrenConnectivity patternsChildrenDevelopmental emergenceAnxietyPhenotypeInstitutionalized youthAmygdalaAdversityCortisolOntogenetic adaptation