2018
Relationship between sipuleucel-T (sip-T) cytolytic T lymphocyte (CTL) activity and overall survival (OS) in patients (pts) with metastatic castration resistant prostate cancer (mCRPC).
Drake C, Antonarakis E, Petrylak D, Quinn D, Kibel A, Chang N, Dearstyne E, Campogan D, Haynes H, Vu T, Sheikh N, Small E. Relationship between sipuleucel-T (sip-T) cytolytic T lymphocyte (CTL) activity and overall survival (OS) in patients (pts) with metastatic castration resistant prostate cancer (mCRPC). Journal Of Clinical Oncology 2018, 36: 5027-5027. DOI: 10.1200/jco.2018.36.15_suppl.5027.Peer-Reviewed Original ResearchPD14-06 SIPULEUCEL-T (SIP-T) WITH ENZALUTAMIDE (ENZ) (STRIDE): CLINICAL OUTCOMES IN PATIENTS (PTS) WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER (MCRPC) BY BASELINE (BL) PROSTATE-SPECIFIC ANTIGEN (PSA) QUARTILES
Corman J, Petrylak D, Drake C, Pieczonka C, Karsh L, Concepcion R, Garcia J, Dunshee C, Van Mouwerik T, Tyler R, Chang N, Quinn D. PD14-06 SIPULEUCEL-T (SIP-T) WITH ENZALUTAMIDE (ENZ) (STRIDE): CLINICAL OUTCOMES IN PATIENTS (PTS) WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER (MCRPC) BY BASELINE (BL) PROSTATE-SPECIFIC ANTIGEN (PSA) QUARTILES. Journal Of Urology 2018, 199: e306-e307. DOI: 10.1016/j.juro.2018.02.792.Peer-Reviewed Original ResearchOverall survival and immune responses with sipuleucel-T and enzalutamide: STRIDE study.
Petrylak D, Drake C, Pieczonka C, Corman J, Garcia J, Dunshee C, Van Mouwerik T, Tyler R, Chang N, Quinn D. Overall survival and immune responses with sipuleucel-T and enzalutamide: STRIDE study. Journal Of Clinical Oncology 2018, 36: 246-246. DOI: 10.1200/jco.2018.36.6_suppl.246.Peer-Reviewed Original ResearchDisease progressionMetastatic castration-resistant prostate cancerCastration-resistant prostate cancerKaplan-Meier analysisNew safety concernsMedian followBaseline characteristicsOverall survivalPSA responseMedian ageClinical outcomesHormonal agentsProstate cancerClinical impactLaboratory valuesSTRIDE studyImmune responseLarger studySipuleucelWkSafety concernsFirst studyImmunotherapyPatientsFollow
2016
Immunogenicity of sipuleucel-T (Sip-T) in abiraterone (Abi)/enzalutamide (Enz) sensitive and resistant metastatic castrate-resistant prostate cancer (mCRPC).
Small E, Fong L, Quinn D, Drake C, Campogan D, Vu T, Sheikh N, Chang N, Petrylak D. Immunogenicity of sipuleucel-T (Sip-T) in abiraterone (Abi)/enzalutamide (Enz) sensitive and resistant metastatic castrate-resistant prostate cancer (mCRPC). Journal Of Clinical Oncology 2016, 34: 5077-5077. DOI: 10.1200/jco.2016.34.15_suppl.5077.Peer-Reviewed Original ResearchSipuleucel-T (sip-T)–induced lytic CD8+ T cell responses to target antigens in men with hormone-sensitive and castration-resistant prostate cancer (CRPC).
Antonarakis E, Quinn D, Kibel A, Petrylak D, Vu T, Campogan D, Chang N, Cummings C, Trager J, Chinn J, Sheikh N, Drake C. Sipuleucel-T (sip-T)–induced lytic CD8+ T cell responses to target antigens in men with hormone-sensitive and castration-resistant prostate cancer (CRPC). Journal Of Clinical Oncology 2016, 34: e23116-e23116. DOI: 10.1200/jco.2016.34.15_suppl.e23116.Peer-Reviewed Original Research
2015
Immune response from STRIDE, a randomized, Phase II, open-label study of sipuleucel-T (sip-T) with concurrent vs sequential enzalutamide (enz) administration in metastatic castration-resistant prostate cancer (mCRPC)
Drake C, Quinn D, Dreicer R, Antonarakis E, Shore N, Corman J, Concepcion R, Pieczonka C, Campogan D, Fan L, Chang N, Sheikh N, Petrylak D. Immune response from STRIDE, a randomized, Phase II, open-label study of sipuleucel-T (sip-T) with concurrent vs sequential enzalutamide (enz) administration in metastatic castration-resistant prostate cancer (mCRPC). Journal For ImmunoTherapy Of Cancer 2015, 3: p145. PMCID: PMC4645289, DOI: 10.1186/2051-1426-3-s2-p145.Peer-Reviewed Original Research2526 Immune responses and clinical data from STRIDE, a randomized, phase 2, open label study of sipuleucel-T with concurrent vs sequential enzalutamide administration in metastatic castrationresistant prostate cancer
Petrylak D, Quinn D, Dreicer R, Antonarakis E, Shore N, Corman J, Concepcion R, Pieczonka C, Chang N, DeVries T, Sheikh N, Drake C. 2526 Immune responses and clinical data from STRIDE, a randomized, phase 2, open label study of sipuleucel-T with concurrent vs sequential enzalutamide administration in metastatic castrationresistant prostate cancer. European Journal Of Cancer 2015, 51: s483. DOI: 10.1016/s0959-8049(16)31345-4.Peer-Reviewed Original ResearchImmune response from STRIDE, a randomized, phase 2, open label study of sipuleucel-T (sip-T) with concurrent vs sequential enzalutamide (enz) administration in metastatic castration-resistant prostate cancer (mCRPC).
Quinn D, Drake C, Dreicer R, Antonarakis E, Shore N, Corman J, Concepcion R, Pieczonka C, Chang N, DeVries T, Sheikh N, Petrylak D. Immune response from STRIDE, a randomized, phase 2, open label study of sipuleucel-T (sip-T) with concurrent vs sequential enzalutamide (enz) administration in metastatic castration-resistant prostate cancer (mCRPC). Journal Of Clinical Oncology 2015, 33: 5040-5040. DOI: 10.1200/jco.2015.33.15_suppl.5040.Peer-Reviewed Original Research
2014
A randomized phase II, open-label study of sipuleucel-T with concurrent or sequential enzalutamide in metastatic castration-resistant prostate cancer (mCRPC).
Quinn D, Petrylak D, Pieczonka C, Sandler A, DeVries T, Sheikh N, Drake C. A randomized phase II, open-label study of sipuleucel-T with concurrent or sequential enzalutamide in metastatic castration-resistant prostate cancer (mCRPC). Journal Of Clinical Oncology 2014, 32: e16071-e16071. DOI: 10.1200/jco.2014.32.15_suppl.e16071.Peer-Reviewed Original Research
2013
971 SAFETY AND CHANGES IN LABORATORY PARAMETERS ASSOCIATED WITH SIPULEUCEL-T IN PATIENTS WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER: PHASE 2 PROACT STUDY
Gardner T, Petrylak D, Corman J, Hall S, Weinstein R, Sims R, DeVries T, Higano C. 971 SAFETY AND CHANGES IN LABORATORY PARAMETERS ASSOCIATED WITH SIPULEUCEL-T IN PATIENTS WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER: PHASE 2 PROACT STUDY. Journal Of Urology 2013, 189: e399. DOI: 10.1016/j.juro.2013.02.552.Peer-Reviewed Original ResearchImmune response with sipuleucel-T in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): Phase II ProACT study.
Gardner T, Petrylak D, Corman J, Hall S, Weinstein R, Keyser R, Sims R, Sanders A, Sheikh N, Higano C. Immune response with sipuleucel-T in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): Phase II ProACT study. Journal Of Clinical Oncology 2013, 31: 148-148. DOI: 10.1200/jco.2013.31.6_suppl.148.Peer-Reviewed Original ResearchMetastatic castration-resistant prostate cancerSymptomatic metastatic castration-resistant prostate cancerMemory B cellsImmune responseOverall survivalB cellsOngoing phase 2 studyCastration-resistant prostate cancerAutologous cellular immunotherapyPeripheral immune responsePhase 2 studyProlongs overall survivalST infusionCellular immunotherapySerum antiMemory phenotypeSipuleucelPA2024Prostate cancerCSF titersActivation phenotypeAnti-GMGM-CSFFlow cytometryMature phenotype
2012
123 Time to disease-related pain (TDRP) following sipuleucel-T in asymptomatic patients with metastatic castrate-resistant prostate cancer (mCRPC): Integrated results from three randomized phase 3 trials
Small E, Higano C, Kantoff P, Whitmore J, Frohlich M, Petrylak D. 123 Time to disease-related pain (TDRP) following sipuleucel-T in asymptomatic patients with metastatic castrate-resistant prostate cancer (mCRPC): Integrated results from three randomized phase 3 trials. European Urology Open Science 2012, 11: e123-e123a. DOI: 10.1016/s1569-9056(12)60122-5.Peer-Reviewed Original Research
2011
MP-16.01 Cellular and Humoral Immune System Activation by Sipuleucel-T: Preliminary Data from the OpenACT Phase 2 Trial
Petrylak D, Corman J, Hall S, Nabhan C, Ferrari A, Armstrong A, Dawson N, Sims R, Stewart F, Sheikh N. MP-16.01 Cellular and Humoral Immune System Activation by Sipuleucel-T: Preliminary Data from the OpenACT Phase 2 Trial. Urology 2011, 78: s147. DOI: 10.1016/j.urology.2011.07.369.Peer-Reviewed Original Research
2007
605: Androgen Independent Prostate Cancer (AIPC) Patients who Receive Sipuleucel-T Followed by Docetaxel Have Prolonged Survival
Petrylak D, Schellhammer P, Small E, Frohlich M. 605: Androgen Independent Prostate Cancer (AIPC) Patients who Receive Sipuleucel-T Followed by Docetaxel Have Prolonged Survival. Journal Of Urology 2007, 177: 202. DOI: 10.1016/s0022-5347(18)30845-0.Peer-Reviewed Original Research