2022
Functional Connectivity of the Nucleus Accumbens and Changes in Appetite in Patients With Depression
Kroemer NB, Opel N, Teckentrup V, Li M, Grotegerd D, Meinert S, Lemke H, Kircher T, Nenadić I, Krug A, Jansen A, Sommer J, Steinsträter O, Small DM, Dannlowski U, Walter M. Functional Connectivity of the Nucleus Accumbens and Changes in Appetite in Patients With Depression. JAMA Psychiatry 2022, 79: 993-1003. PMID: 36001327, PMCID: PMC9403857, DOI: 10.1001/jamapsychiatry.2022.2464.Peer-Reviewed Original ResearchConceptsMajor depressive disorderNAcc functional connectivityFunctional connectivityBody weightNucleus accumbensTreatment of MDDResting-state functional connectivityCase-control studySymptom-specific associationsHealthy control participantsIdentification of biomarkersClassification of diagnosesCohort studyMost patientsMean ageDepressive episodeDepressive disorderReduced appetiteMagnetic resonance imaging dataMAIN OUTCOMESubstantial burdenDepressive symptomsPatientsVentromedial prefrontal cortexReward circuitChronic pain precedes disrupted eating behavior in low-back pain patients
Lin Y, De Araujo I, Stanley G, Small D, Geha P. Chronic pain precedes disrupted eating behavior in low-back pain patients. PLOS ONE 2022, 17: e0263527. PMID: 35143525, PMCID: PMC8830732, DOI: 10.1371/journal.pone.0263527.Peer-Reviewed Original ResearchConceptsLow back pain patientsChronic low back pain patientsFat-rich foodsPain patientsChronic painCLBP patientsSBP patientsNucleus accumbensBack pain patientsChronic pain patientsHealthy control subjectsNucleus accumbens volumePain chronificationFat ingestionHedonic feedingPatient populationAccumbens volumeControl subjectsLimbic brainPainEarly coursePatientsBehavioral alterationsHedonic perceptionNeurological standpoint
2020
Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain
Makary MM, Polosecki P, Cecchi GA, DeAraujo IE, Barron DS, Constable TR, Whang PG, Thomas DA, Mowafi H, Small DM, Geha P. Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 10015-10023. PMID: 32312809, PMCID: PMC7211984, DOI: 10.1073/pnas.1918682117.Peer-Reviewed Original ResearchConceptsChronic low back pain patientsLow back pain patientsChronic painPain patientsChronic phaseChronic back pain patientsBack pain patientsRostral anterior cingulate cortexAnterior cingulate cortexAdditional independent datasetsRisk of transitionResting-state activityPersistent painBack painAccumbens volumeHealthy controlsNucleus accumbensPainSeparate cohortPatientsCingulate cortexPrevalent diseaseFunctional connectivityLoss of nucleiSubcortical signatures
2015
Weighing the evidence: Variance in brain responses to milkshake receipt is predictive of eating behavior
Kroemer NB, Sun X, Veldhuizen MG, Babbs AE, de Araujo IE, Small DM. Weighing the evidence: Variance in brain responses to milkshake receipt is predictive of eating behavior. NeuroImage 2015, 128: 273-283. PMID: 26724781, DOI: 10.1016/j.neuroimage.2015.12.031.Peer-Reviewed Original ResearchConceptsBrain responsesHigher body mass indexAd libitum food consumptionBody mass indexGreater weight lossNucleus Accumbens ResponseFunctional magnetic resonanceMilkshake receiptMass indexPlasma insulinPlasma glucoseMetabolic parametersDietary disinhibitionStriatal activityVariable response patternsWeight lossFood stimuliMetabolic responseSensory stimuliFood consumptionIntra-individual variationVariable responseMilkshakeMagnetic resonanceResponse patterns
2013
Metabolic Regulation of Brain Response to Food Cues
de Araujo IE, Lin T, Veldhuizen MG, Small DM. Metabolic Regulation of Brain Response to Food Cues. Current Biology 2013, 23: 878-883. PMID: 23643837, PMCID: PMC3767438, DOI: 10.1016/j.cub.2013.04.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood GlucoseFeeding BehaviorHypothalamusMagnetic Resonance ImagingNucleus AccumbensPolysaccharides